Efficacy of Diffusion-Weighted Imaging in Neoadjuvant Chemotherapy for Osteosarcoma: A Systematic Review and Meta-Analysis

Yuan, Wenzhao; Yu, Qiuyi; Wang, Zhen; Huang, Jian; Wang, Jienan

doi:10.1016/j.acra.2020.11.013

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…More specifically, for ΔADCmin <10.5%, an AUC value of 0.807 could identify different response groups. A meta‐analysis conducted by Yuan et al 56 revealed that both pretreatment and post‐treatment ADC differences and ratios could be used to assess the efficacy of chemotherapy, with significantly higher ADC differences and ratios in the good response group than in the poor response group (mean differences of 0.33 and 28.34, respectively).…”

Section: Methodsmentioning

confidence: 99%

Imaging Assessment of the Efficacy of Chemotherapy in Primary Malignant Bone Tumors: Recent Advances in Qualitative and Quantitative Magnetic Resonance Imaging and Radiomics

Liu

Duan

Fang

et al. 2023

Magnetic Resonance Imaging

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Section: Methodsmentioning

confidence: 99%

Imaging Assessment of the Efficacy of Chemotherapy in Primary Malignant Bone Tumors: Recent Advances in Qualitative and Quantitative Magnetic Resonance Imaging and Radiomics

Liu

Duan

Fang

et al. 2023

Magnetic Resonance Imaging

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“…An increase in the ADC value can be observed at an earlier stage than a decrease in tumor size. 125 Magnetic resonance spectroscopy Magnetic resonance spectroscopy (MRS) uses the same principles of signal acquisition as other MRI techniques. MRS studies in a medical context usually involve the detection of radiofrequency electromagnetic signals that are produced by chemical compounds.…”

Section: Dynamic Contrast-enhanced Mrimentioning

confidence: 99%

Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

Bai

Qiu

Zhang

2023

Sig Transduct Target Ther

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Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing cells as in cytotoxic chemotherapy. The Response Evaluation Criteria in Solid Tumor (RECIST) system has been used to assess tumor response to therapy via changes in the size of target lesions as measured by calipers, conventional anatomically based imaging modalities such as computed tomography (CT), and magnetic resonance imaging (MRI), and other imaging methods. However, RECIST is sometimes inaccurate in assessing the efficacy of targeted therapy drugs because of the poor correlation between tumor size and treatment-induced tumor necrosis or shrinkage. This approach might also result in delayed identification of response when the therapy does confer a reduction in tumor size. Innovative molecular imaging techniques have rapidly gained importance in the dawning era of targeted therapy as they can visualize, characterize, and quantify biological processes at the cellular, subcellular, or even molecular level rather than at the anatomical level. This review summarizes different targeted cell signaling pathways, various molecular imaging techniques, and developed probes. Moreover, the application of molecular imaging for evaluating treatment response and related clinical outcome is also systematically outlined. In the future, more attention should be paid to promoting the clinical translation of molecular imaging in evaluating the sensitivity to targeted therapy with biocompatible probes. In particular, multimodal imaging technologies incorporating advanced artificial intelligence should be developed to comprehensively and accurately assess cancer-targeted therapy, in addition to RECIST-based methods.

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“…88,91 Assessment of primary tumor response to neoadjuvant chemotherapy using PET and MRI are current topics of research. Numerous studies analyzing parameters derived from 18F-FDG PET, [70][71][72][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108] MRI with DWI and apparent diffusion coefficient (ADC) maps, 92,[109][110][111][112][113][114][115][116][117][118][119] and dynamic contrast-enhanced MRI [119][120][121][122][123][124] show the promise of imaging biomarkers for noninvasive assessment of primary tumor response and prognosis (Tables 1-4).…”

Section: Primary Tumor Response Assessmentmentioning

confidence: 99%

Imaging of pediatric bone tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper

Cederberg

Iyer

Chaturvedi

et al. 2022

Pediatric Blood & Cancer

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Efficacy of Diffusion-Weighted Imaging in Neoadjuvant Chemotherapy for Osteosarcoma: A Systematic Review and Meta-Analysis

Cited by 9 publications

References 20 publications

Imaging Assessment of the Efficacy of Chemotherapy in Primary Malignant Bone Tumors: Recent Advances in Qualitative and Quantitative Magnetic Resonance Imaging and Radiomics

Imaging Assessment of the Efficacy of Chemotherapy in Primary Malignant Bone Tumors: Recent Advances in Qualitative and Quantitative Magnetic Resonance Imaging and Radiomics

Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

Imaging of pediatric bone tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper

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