Efficacy of Dialectical Comprehensive Treatment of Traditional Chinese Medicine in Patients with Chronic Stable Heart Failure: A Randomized Controlled Trial

Yang, Lixiang; Chen, Yuanyuan; Lou, Fei; Zhao, Xinquan; Zhou, Jia

doi:10.1155/2022/5408063

Cited by 3 publications

(19 citation statements)

References 45 publications

(41 reference statements)

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“…In the treatment group, Huoxue Wenyang Tang (Hwalhyeolonyang-tang, in Korean) was used in 2 studies, [ 23 , 24 , 29 ] Wenyang Buxin Tang (Onyangbosimtang, in Korean) in 1 study, [ 25 ] Xinshuai Qixu I Hao Fang (Shimsoigiheo1hobang, in Korean) in 1 study, [ 26 ] Sini Tang Jiajian (Sayeoktanggagam, in Korean) in 1 study, [ 27 ] and Fumai Tang (Bokmaektang, in Korean) [ 28 ] in 1 study. One study [ 30 ] combined Baoyaun Tang with Taohong Siwu Tang (Bowoontang hap Dohongsamultang, in Korean) or Zhenwu Tang with Xuefu Zhuyu Tang (Hyeolbuchukeotang, in Korean) or Gualou Xiebai Banxia Tang (Gwahroohaebaekbahnhahtang, in Korean) based on pattern identification. The most commonly used herbal medicines were Astragali Radix, Salviae Miltiorrhizae Radix, Liriopis Radix, and Ramulus Cinnamomi, which were used in 5 studies, while orally administered decoctions were used in all 7 study formulations (Appendix II, http://links.lww.com/MD/N256 ).…”

Section: Resultsmentioning

confidence: 99%

“…The most commonly used herbal medicines were Astragali Radix, Salviae Miltiorrhizae Radix, Liriopis Radix, and Ramulus Cinnamomi, which were used in 5 studies, while orally administered decoctions were used in all 7 study formulations (Appendix II, http://links.lww.com/MD/N256 ). For acupuncture treatment, 3 studies [ 23 , 24 , 26 , 29 ] used acupuncture, 3 studies [ 25 , 27 , 28 ] used warm acupuncture, and 1 study [ 30 ] used a combination of acupuncture, auricular acupuncture, and moxibustion. The most commonly used acupuncture point was Neiguan (PC6), which was utilized in 6 studies [ 23 , 24 , 26 – 30 ] (Appendix III, http://links.lww.com/MD/N257 ).…”

Section: Resultsmentioning

confidence: 99%

“…For acupuncture treatment, 3 studies [ 23 , 24 , 26 , 29 ] used acupuncture, 3 studies [ 25 , 27 , 28 ] used warm acupuncture, and 1 study [ 30 ] used a combination of acupuncture, auricular acupuncture, and moxibustion. The most commonly used acupuncture point was Neiguan (PC6), which was utilized in 6 studies [ 23 , 24 , 26 – 30 ] (Appendix III, http://links.lww.com/MD/N257 ). CWMs was administered as a treatment for HF in all studies.…”

Section: Resultsmentioning

confidence: 99%

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Combination therapy of acupuncture and herbal medicine for heart failure: A systematic review and meta-analysis

Jeong,

Lee,

Kim

et al. 2024

Medicine

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Background: Heart failure (HF) is characterized by functional or structural dysfunction of the heart, resulting in impaired blood ejection or ventricular filling. Conventional Western Medicine (CWM) remains the mainstay of treatment for HF; however, the occurrence of adverse events (AEs) necessitates the exploration of alternative treatments. Herbal medicine and acupuncture are adjunctive therapies for HF and have shown potential for improving heart function. This systematic review and meta-analysis aimed to assess the effectiveness and safety of acupuncture and herbal medicine in treating HF. Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Citation Information by National Institute of Informatics, KoreaMed, Research Information Sharing Service, and DBpia were searched for randomized controlled trials (RCTs) evaluating the effects of acupuncture and herbal medicine along with CWM as adjunctive treatments for HF, published from inception to May 31, 2024. Treatment effectiveness was determined by evaluating the left ventricular ejection fraction as the primary metric, along with the measurement of the total effective rate, brain natriuretic peptide level, N-terminal prohormone of brain natriuretic peptide level, left ventricular end-diastolic volume, and left ventricular end-systolic volume; the administration of the Minnesota Living with Heart Failure Questionnaire; and the conduct of a 6-minute walk test. Treatment safety was evaluated based on the incidence of AEs. The methodological quality of all included RCTs was assessed using the Cochrane risk of bias tool. A meta-analysis was performed using Review Manager, version 5.4.1. Results: Of the 133 publications identified, 8 RCTs met the inclusion criteria. The meta-analysis showed significant improvements in left ventricular ejection fraction, brain natriuretic peptide levels, N-terminal prohormone of brain natriuretic peptide levels, left ventricular end-systolic volume, left ventricular end-diastolic volume, and 6-minute walk test results. Additionally, significant differences were observed in the total effective rate and Minnesota Living with Heart Failure Questionnaire responses. No significant medication-related AEs occurred in the intervention group. Conversely, 7 control patients developed well-known AEs associated with CWM. Conclusion: Acupuncture combined with herbal medicine and CWM is more effective than CWM alone, indicating a safe treatment approach. Consequently, the proactive administration of acupuncture alongside herbal medicine to patients with HF can be undertaken without concerns regarding AEs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Combination therapy of acupuncture and herbal medicine for heart failure: A systematic review and meta-analysis

Jeong,

Lee,

Kim

et al. 2024

Medicine

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“…Various studies have demonstrated that accurate treatment based on syndrome differentiation significantly enhances the efficacy of acupuncture and moxibustion. [44][45][46] Therefore, customizing the selection of acupuncture points according to the different types of mammary hyperplasia can improve the treatment effectiveness through strategic point selection. Sixthly, Empirical effect points are points selected by clinicians according to their own or others' clinical practice experience and have obvious curative effects on some diseases.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness and Safety of Acupuncture for Mammary Hyperplasia: A Systematic Review and Meta-Analysis

Li,

Zhang,

et al. 2024

JPR

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This study aims to systematically evaluate the effectiveness and safety of acupuncture in treating mammary hyperplasia. Methods: A comprehensive search was conducted in various databases, including PubMed, Web of Science, Cochrane Library, Embase, SinoMed, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP Database, from their inception until July 2023. Only randomized controlled trials (RCTs) researching the use of acupuncture for mammary hyperplasia were included. Quality assessment and data analysis were performed using RevMan 5.3 software. Results: Eight RCTs, comprising 573 patients, were included in this analysis. The meta-analysis revealed that in the acupuncture group, the experimental group was better than the control group in improving breast pain, breast lump extent, and the texture of breast lump (P=0.0007, I 2 =61%; P=0.02, I 2 =0%; P=0.0002, I 2 =0%). We found that both could be improved, but after statistical analysis, there was no significant advantage in the acupuncture group compared with the patent Chinese medicine group (p>0.05). Conclusion: Acupuncture appears to be an effective and safe treatment for mammary hyperplasia, providing pain relief and reducing mass volume, texture, and extent. However, the insufficient quality of the available evidence indicates the need for further methodologically rigorous and convincingly designed studies to determine the efficacy and safety of acupuncture in the treatment of breast hyperplasia.

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“…Rational comprehensive treatment with TCM could effectively improve cardiac function and clinical treatment effects and is worthy of clinical application. [ 10 , 11 ] Heart failure is a major health problem worldwide. Traditional Chinese medicine alone or combined with modern medicine strategies can increase the success rate of cardiovascular disease treatment.…”

Section: Introductionmentioning

confidence: 99%

Identification of key genes associated with heart failure based on bioinformatics analysis and screening of traditional Chinese medicines for the prevention and treatment of heart failure

Luo,

Wang,

Zhang

et al. 2023

Medicine

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Heart failure (HF) is the final stage of heart disease. An increasing number of experiments and clinical reports have shown that traditional Chinese medicine (TCM) has many therapeutic effects and advantages in treating HF. In this study, we used bioinformatics methods to screen key genes and predict the components of Chinese herbal medicines with preventive and therapeutic effects on HF. GSE120895 and GSE21610 HF chips were downloaded from the Gene Expression Omnibus database. We screened differentially expressed genes (DEGs). Weighted gene coexpression network analysis was performed to determine key modules. Genes in key modules were used for Gene Ontology and Kyoto Encyclopedia of Genes Genomes analysis to determine the biological functions. Finally, receiver operating characteristic curve analysis was used to screen out key genes, and single-sample GSEA was conducted to screen TCM compounds and effective ingredients of TCM compounds related to HF. We have selected a key module (MeTerquoise) and identified 489 DEGs, of which 357 are up regulated and 132 are down regulated. Gene Ontology and Kyoto Encyclopedia of Genes Genomes analyses indicated that the DEGs were associated with the extracellular matrix, fat metabolism and inflammatory response. We identified IL2, CXCR4, CCL5, THY1, CCN2, and IL7R as key genes. Single-sample GSEA showed that key genes were mainly related to energy metabolism, mitochondrial oxidative phosphorylation, extracellular matrix, and immunity. Finally, a total of 70 TCM compounds and 30 active ingredients of TCM compounds were identified. Bioinformatics methods were applied to preliminarily predict the key genes and TCM compounds involved in HF. These results provide theoretical support for the treatment of HF with TCM compounds and provide targets and research strategies for the development of related new Chinese medicines.

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Efficacy of Dialectical Comprehensive Treatment of Traditional Chinese Medicine in Patients with Chronic Stable Heart Failure: A Randomized Controlled Trial

Cited by 3 publications

References 45 publications

Combination therapy of acupuncture and herbal medicine for heart failure: A systematic review and meta-analysis

Combination therapy of acupuncture and herbal medicine for heart failure: A systematic review and meta-analysis

The Effectiveness and Safety of Acupuncture for Mammary Hyperplasia: A Systematic Review and Meta-Analysis

Identification of key genes associated with heart failure based on bioinformatics analysis and screening of traditional Chinese medicines for the prevention and treatment of heart failure

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