Efficacy of Diabetinol™ on glycemic control in insulin resistant hamsters and subjects with impaired fasting glucose – a pilot study

Judy, William V.; Stogsdill, W. W.; Judy, Daniel; Judy, Janet; Sharma, Prachi; Evans, Malkanthi; Guthrie, Najla

doi:10.1016/j.jff.2010.04.005

Cited by 13 publications

(10 citation statements)

References 27 publications

(22 reference statements)

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“…Hamsters (n=18) were fed regular chow, 60% fructose or a 60% fructose diet + 1% Diabetinol ® . At the end of the study (Day 49), hamsters fed 60% fructose + 1% Diabetinol ® demonstrated lower blood glucose, total cholesterol and triacylglycerol levels as compared to the fructose-fed animals (Judy et al, 2010).…”

Section: Metabolic Syndromementioning

confidence: 95%

“…Results from previous experimental and clinical studies have suggested that citrus PMFs may improve glycemic control and reduce insulin resistance ., Miyata et al, 2011Li et al, 2006;Judy et al, 2010).…”

Section: Metabolic Syndromementioning

confidence: 99%

“…Subjects included were between ages of 18-75 years and had a body mass index (BMI) 25.0 to 39.9kg/m 2 , were weight stable (for 3 months prior to study), had a fasting glucose level between 6.1 and 9.0mmol/L (109.8-162.0mg/dL), and a HbA1c level<7%. Subjects were excluded from participating if they were diabetic and required insulin therapy (Judy et al, 2010).…”

Section: Subjects and Study Designmentioning

confidence: 99%

“…These studies were conducted at KGK Synergize, Inc London, ON, Canada and SIBR Research, Inc., West Bradenton, FL, USA respectively. The results of the Diabetinol ® study are published in Judy et al, 2010. The authors would like to thank J. Baisley for his technical expertise.…”

Section: Acknowledgementsmentioning

confidence: 99%

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Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Evans¹,

Sharma²,

Guthrie³

2012

Readings in Advanced Pharmacokinetics - Theory, Methods and Applications

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Section: Metabolic Syndromementioning

confidence: 95%

Section: Metabolic Syndromementioning

confidence: 99%

Section: Subjects and Study Designmentioning

confidence: 99%

Section: Acknowledgementsmentioning

confidence: 99%

See 2 more Smart Citations

Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Evans¹,

Sharma²,

Guthrie³

2012

Readings in Advanced Pharmacokinetics - Theory, Methods and Applications

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“…In a previous study, Diabetinol ® supplementation for 3 months in subjects with mild impaired fasting glucose showed significantly reduced peak hyperglycemic response, TC, and LDL-C levels and a trend toward decreased HbA 1c levels. 36 We hypothesized that the results of the previous study could be extended, to subjects with greater severity of impaired fasting glucose, with longer supplementation of Diabetinol ® . Thus, the objective of this study was to evaluate the antidiabetic and antihyperlipidemic potential of Diabetinol ® in a 6-month study in people with diabetes, on medication, but not meeting the AACE and American Diabetes Association (ADA) targets of control.…”

Section: Introductionmentioning

confidence: 99%

Randomized, double-blind, placebo-controlled, clinical study on the effect of Diabetinol® on glycemic control of subjects with impaired fasting glucose

Evans¹,

Judy²,

Wilson³

et al. 2015

DMSO

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BackgroundThis study investigated the efficacy of Diabetinol® in people with diabetes on medication but not meeting the American Association of Clinical Endocrinologists and American Diabetes Association glycemic, blood pressure, and lipid targets.Subjects and methodsFifty subjects, aged 18–75 years, with fasting blood glucose ≤15.4 mmol/L, hemoglobin A1c levels ≤12%, and a body mass index between 25 and 40 kg/m2, were enrolled in a 24-week, randomized, double-blind, placebo-controlled, parallel study. Diabetinol® or placebo was administered as 2×525 mg capsules/day.ResultsIn the Diabetinol® group, 14.3% versus 0% in the placebo group, 33.3% versus 15.4% in placebo, 20.0% versus 12.5% in placebo, and 83.3% versus 60% in placebo achieved the American Association of Clinical Endocrinologists and American Diabetes Association targets for hemoglobin A1c, low-density lipoprotein, total cholesterol, and systolic blood pressure, respectively. There was no difference in the maximum concentration (Cmax) of serum glucose or area under the curve (AUC)0–240 minutes. The time to Cmax was longer for participants on Diabetinol® than placebo group at week 12 (P=0.01). Fasting blood glucose increased from baseline to week 24 in both groups; however, this increase was 14.3 mg/dL lower in the Diabetinol® group versus placebo. The Diabetinol® group showed an increase of 5.53 mg/dL in fasting insulin at week 12 (P=0.09) and 3.2 mg/dL at week 24 (P=0.41) over and above the placebo group. A decrease of 1.5% in total cholesterol, 5.8% in low-density lipoprotein, and a 1.6% increase in high-density lipoprotein concentrations were seen in the Diabetinol® group. Diabetinol® improved 6-month oral glucose tolerance test and 2-hour postprandial glucose profiles in participants between 40 and 60 years of age.ConclusionThe current study suggests a role for Diabetinol® as an adjunctive therapy for glycemic maintenance and for decreasing the risk of diabetes-associated comorbidities in type 2 diabetic patients on conventional therapies.

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Potential Value‐Added Co‐products from Citrus Fruit Processing

Manthey

Bergeron²,

Carrier

et al. 2012

Biorefinery Co‐Products

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Efficacy of Diabetinol™ on glycemic control in insulin resistant hamsters and subjects with impaired fasting glucose – a pilot study

Cited by 13 publications

References 27 publications

Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Randomized, double-blind, placebo-controlled, clinical study on the effect of Diabetinol® on glycemic control of subjects with impaired fasting glucose

Potential Value‐Added Co‐products from Citrus Fruit Processing

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Efficacy of Diabetinol™ on glycemic control in insulin resistant hamsters and subjects with impaired fasting glucose – a pilot study

Cited by 13 publications

References 27 publications

Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Randomized, double-blind, placebo-controlled, clinical study on the effect of Diabetinol&reg; on glycemic control of subjects with impaired fasting glucose

Potential Value‐Added Co‐products from Citrus Fruit Processing

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Randomized, double-blind, placebo-controlled, clinical study on the effect of Diabetinol® on glycemic control of subjects with impaired fasting glucose