Efficacy of Dehydrated Human Amnion Chorion Membrane in the Treatment of Diabetic Foot Ulcers: A Review

Au, Andrew S; Leung, Wai Yuk; Stavosky, James W.

doi:10.7547/17-154

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The obtained results are quite consistent with those obtained in other clinical studies in which various preparations of amniotic membranes were used: Grafix [60], Epifix [65,66,67], Amnioband [68], AmnioExcel [69,70], EpifixApligraf [67] Grafix NEOX Cord [71], dHACM [72,73,83]. According to the analysis of retrospective studies on the effectiveness of AM in the treatment of ulcers in DFS, most randomized clinical trials of tissue therapy were completed in a much shorter period of time compared to standard treatment groups.…”

Section: Resultssupporting

confidence: 89%

“…Progressive techniques of cryopreservation of human amniotic membrane provide after thawing the preservation in the donor allogeneic AM of multipotent mesenchymal stromal cells capable to migrate into the wound after the application and activate resident patient stem cells, thereby enhancing wound healing. This property is especially important for the elderly, as with age there is a decrease in the number of MSCs and their dysfunction, which significantly inhibits the healing of wounds [83].…”

Section: Resultsmentioning

confidence: 99%

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The clinical effectiveness of cryopreserved human amniotic membrane in diabetic foot syndrome

Ustymenko¹,

Nemtinov²,

Bolgarska³

et al. 2021

COT

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Diabetic foot syndrome with long-term unhealed wounds is the most common complication and cause of limb amputation in diabetes. The search for effective therapeutic agents and their inclusion in treatment protocols is a priority due to the increase in the number of cases of this socially significant disease and disability among the working population every year. The aim of the study is to evaluate the effectiveness of cryopreserved human amniotic membrane in the treatment of long-term non-healing wounds of the lower extremities in diabetic foot syndrome. Materials and methods. The pilot clinical study described 4 clinical cases of treatment of patients with diabetes mellitus type I and II (1 woman and 3 men aged 52 to 68 years) with long-term unhealed wounds of the limbs under standard therapy. After previous wound sanation the applications of the cryopreserved human amniotic membrane were performed. Once a week after the application, the dynamics of wound healing was assessed. Blood glucose levels were determined before amniotic membrane treatment and two hours after the procedure. Results. As a results of weekly applications of human amniotic membrane there was a gradual decrease in the area of the wound from the original size and increase the rate of healing. Thus, at the time of the second visit (after 7 days) the reduction in the area of the ulcer from the initial size in patient 1 was 33 %, patient 2 – 25 %, patient 3 – 33 % on the sole and patient 4 – 3 %, and the healing rate – 4.7 %, 3.6 %, 4.7 % and 0.43 % per day, respectively. The use of human amniotic membrane did not affect blood glucose levels when comparing values before application and two hours after the procedure. Regular follow-up visits of patients 3, 6, 9 and 12 months after the start of the study showed no recurrence of ulcers. Conclusions. It has been shown that the use of cryopreserved human amniotic membrane in patients with diabetes mellitus and diabetic foot syndrome with long-term unhealed wounds results in complete healing of ulcers with stable remission during the year of observation.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

The clinical effectiveness of cryopreserved human amniotic membrane in diabetic foot syndrome

Ustymenko¹,

Nemtinov²,

Bolgarska³

et al. 2021

COT

View full text Add to dashboard Cite

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Non-autologous Biologics

Sand

2024

Essentials of Regenerative Medicine in Interventional Pain Management

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Skin Grafting for Dermatologists: Past, Present, and Future

Maskan Bermudez,

Sa,

Hargis

et al. 2024

Curr Derm Rep

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Purpose of This Review Skin grafting is a surgical procedure that involves replacing damaged or missing skin with healthy skin. This technique helps protect wounds, promotes healing, and enhances functionality and appearance. Skin grafting can be beneficial in treating burns, traumatic injuries, chronic ulcers, surgical wounds, and congenital defects, among others. Recent Findings A range of cellular and tissue-based products (CTPs) can be employed, either in conjunction with autologous skin grafts or independently, to facilitate wound healing. Human skin allografts, sourced from donated human skin, often obtained from cadavers, serve as a valuable resource for wound protection. Allogeneic matrices, comprising neonatal fibroblasts or membranes, alongside chorion, amnion, and other placental products, provide a means to accelerate the wound healing process. Composite matrices, which combine human keratinocytes, fibroblasts, and xenogeneic collagen, provide a solution to replicate the complexity of natural skin. Moreover, acellular matrices derived from xenogeneic collagen or tissue offer a versatile platform for tissue regeneration. Conclusion Skin grafting is a complex procedure that requires careful planning and postoperative care. Success depends on factors like the type of graft, wound management, and overall health of the patient. Skin grafting has evolved with advancements in surgery, anesthesia, and wound care and remains a crucial technique for restoring function and appearance.

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Efficacy of Dehydrated Human Amnion Chorion Membrane in the Treatment of Diabetic Foot Ulcers: A Review

Cited by 5 publications

References 26 publications

The clinical effectiveness of cryopreserved human amniotic membrane in diabetic foot syndrome

The clinical effectiveness of cryopreserved human amniotic membrane in diabetic foot syndrome

Non-autologous Biologics

Skin Grafting for Dermatologists: Past, Present, and Future

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