Efficacy of Debridement Alone Versus Debridement Combined with Topical Antifungal Nail Lacquer for the Treatment of Pedal Onychomycosis: A Randomized, Controlled Trial

Malay, D. Scot; Yi, Sang-Heon; Borowsky, Pamela; Downey, Michael S.; Mlodzienski, Alan J.

doi:10.1053/j.jfas.2008.12.012

Cited by 57 publications

(41 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eight studies describe baseline characteristics of onychomycosis patients using PRO instruments [10,11,12,13,14,15,16,17], while 8 other studies use nonvalidated instruments or instruments nonspecific to onychomycosis (Table 1) [7,18,19,20,21,22,23,24,25]. Ten studies used PRO instruments to evaluate onychomycosis treatments (Table 2) [26,27,28,29,30,31,32,33,34,35]. …”

Section: Resultsmentioning

confidence: 99%

“…Only 3 studies used a validated, onychomycosis-specific PRO instrument, the OnyCOE-t™ [31,33,34]. Four studies used instruments derived from previously validated questionnaires [27,28,29,30], 1 study used a validated instrument for podiatry-related QOL [32], and 2 studies used instruments of unclear origins [26,35]. There were 2,224 patients in 4 randomized controlled trials, 1,825 patients in 5 case series, and 142 patients in 1 cross-sectional study.…”

Section: Resultsmentioning

confidence: 99%

“…Malay et al [32] used the Bristol Foot Score, a validated, podiatry-specific PRO instrument to evaluate QOL in 55 toenail onychomycosis patients who underwent either debridement alone or debridement with adjunct ciclopirox treatment in a multicenter randomized controlled trial. Debridement alone did not result in any mycological cure, while the addition of ciclopirox resulted in a cure rate of 76.7%.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Patient-Reported Outcomes in Onychomycosis: A Review of Psychometrically Evaluated Instruments in Assessing Treatment Effectiveness

Wang

Wiznia

Rieder

2017

Skin Appendage Disord

View full text Add to dashboard Cite

Purpose: Onychomycosis is the most common nail disorder and causes morbidity and impaired quality of life (QOL). Patient-reported outcomes (PRO) are patients' assessment of their health status or treatment response. PROs help assess what is most bothersome to patients to identify targets for intervention. We sought to review the PRO instruments currently used to assess QOL and treatment response in onychomycosis patients. Procedures: A systematic review was performed by searching PubMed, Embase, CINAHL, and PsycINFO databases through December 31, 2016, to identify all English language literature on onychomycosis, PRO, and QOL. Results: Currently, 5 validated PRO instruments exist specifically for onychomycosis. Oral therapies were most extensively studied using PRO instruments. QOL data generally correlated with clinical change, although patients sometimes reported improvement without any clinically significant nail clearance. The only psychometrically validated PRO instrument used to evaluate treatment response is the OnyCOE-t™. Conclusions: Clinicians may underestimate the impact of onychomycosis on patients. With recent initiatives from health-care management organizations to improve patient experience and the recent approval of expensive and nonsuperior topical antifungal medications, PROs will be increasingly important in onychomycosis to assess patient priorities and optimize treatment. Future research should evaluate these instruments in special populations and fingernail disease.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Patient-Reported Outcomes in Onychomycosis: A Review of Psychometrically Evaluated Instruments in Assessing Treatment Effectiveness

Wang

Wiznia

Rieder

2017

Skin Appendage Disord

View full text Add to dashboard Cite

show abstract

“…Кроме того, в настоящее время известно достаточ-ное количество исследований, на основании которых можно сделать вывод, что ни один из методов удале-ния ногтя при онихомикозе в одиночку не является достаточным для излечения пациента [20,21]. Соглас-но последним рекомендациям Британского общества дерматовенерологов (2014), хирургическое удаление ногтевой пластины с последующим назначением мест-ной терапии не продемонстрировало эффективности по результатам рандомизированных исследований, в связи с чем не может быть рекомендовано для тера-пии онихомикозов.…”

Section: Wounds and Wound Infections The Prof Bm Kostyuchenok Journalunclassified

Onychomycoses: The Views of a Dermatologist and a Surgeon

Burova¹,

Привольнев²

2015

jour

View full text Add to dashboard Cite

“…Malay, et al, 24 in an industry sponsored randomized controlled trial compared nail debridement with nail debridement and topical antifungal nail lacquer for the treatment of onychomycosis. The primary outcome was mycological cure.…”

Section: Detecting Misleading Claims In Clinical Trialsmentioning

confidence: 99%

Special Considerations When Reviewing Industry Sponsored Trials

Turlik¹

2009

FAOJ

View full text Add to dashboard Cite

Efficacy of Debridement Alone Versus Debridement Combined with Topical Antifungal Nail Lacquer for the Treatment of Pedal Onychomycosis: A Randomized, Controlled Trial

Cited by 57 publications

References 26 publications

Patient-Reported Outcomes in Onychomycosis: A Review of Psychometrically Evaluated Instruments in Assessing Treatment Effectiveness

Patient-Reported Outcomes in Onychomycosis: A Review of Psychometrically Evaluated Instruments in Assessing Treatment Effectiveness

Onychomycoses: The Views of a Dermatologist and a Surgeon

Special Considerations When Reviewing Industry Sponsored Trials

Contact Info

Product

Resources

About