Efficacy of daptomycin in the treatment of enterococcal endocarditis: a 5 year comparison with conventional therapy

Cerón, Inés; Bouza, Emilio; Bermejo, Javier; Eworo, Alia; Fernández‐Cruz, Ana; Cuerpo, Gregorio; Robles, José A. García; Vecchio, Marcela González del; Mansilla, Ana González; Ramallo, Víctor José González; Kestler, Martha; Marı́n, Mercedes; Sellés, Manuel Martínez; Menárguez, Ma Cruz; Muñóz, Patricia; Pérez, Esther; Pinilla, Blanca; Pinto, Ángel González; Roda, J.; Rodríguez‐Créixems, Marta; Rodríguez, Hugo; Ruíz, Manuel; Salas, Marisol; Segado, A.; Valerio, Maricela; Vázquez, Pilar; Verde, Eduardo

doi:10.1093/jac/dku004

Cited by 27 publications

(46 citation statements)

References 18 publications

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“…Для текущего обзора было отобрано 5 научных исследований [15][16][17][18][19], удовлетворяющих ранее указанным критериям поиска. Все исследования были относительно небольшие (от 32 до 246 человек).…”

Section: результатыunclassified

Antimicrobial Treatment of Infective Endocarditis, Caused by <i>Enterococcus Faecalis

Ших

Морозова

Дроздов

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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The frequency of infective endocarditis (IE) has increased 3 times over the past 30 years. The incidence of IE morbidity is recorded in all countries of the world and in the Russian Federation more than 40 people per 1 million population get sick. One of the most frequent causative agents of infective endocarditis is Enterococcus faecalis (E. faecalis), which takes the third place in the structure of the frequency of IE pathogens. Enterococcal IE remains a disease with high mortality, despite the emergence of new groups of antibacterial drugs. This review includes the results of studies of the efficacy and safety of various antimicrobial regimens of IE caused by E. faecalis. The analysis of data from foreign and native studies of antimicrobial treatment in patients with infective endocarditis, accompanied by enterococcal bacteremia is presented in the review. The search for literature performed by using medical databases: MEDLINE, EMBASE, eLIBRARY. The current review included studies of the efficacy and safety of antimicrobial treatment. The main antibiotic therapy regimens of IE caused by E. faecalis include 2 beta-lactam antibiotics or a combination of ampicillin and gentamicin, according to the results of 5 found studies. Found antimicrobial regimens significantly did not affect mortality. Data from international registries testify to the efficacy and safety of daptomycin monotherapy for enterococcal endocarditis. Linezolid and daptomycin are the main drugs of treating infective endocarditis caused by vancomycin-resistant enterococci. Native studies report of a high level of resistance of enterococcal strains to beta-lactam antibacterial drugs. The duration of fever, the frequency of surgical heart valves interventions, the duration of bacteremia are not fully represented in each of the studies, and it is difficult to evaluate these factors. Ampicillin+ceftriaxone and ampicillin+gentamicin are the main antimicrobial treatment regimens of enterococcal endocarditis. Efficacy of these regimens is not significantly different. Treatment of IE should be carried out taking into the epidemiological situation and the strain resistance.

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Section: результатыunclassified

Antimicrobial Treatment of Infective Endocarditis, Caused by <i>Enterococcus Faecalis

Ших

Морозова

Дроздов

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…The rationale for why higher doses of daptomycin may be required for the optimal treatment of such serious infections is based on the observation that daptomycin MICs for Enterococcus species are typically higher than those for other Gram-positive organisms (0.5-4 vs 0.25-1 mg/L) [ 170 ]. On the other hand, there have been reports of unsatisfactory outcomes of daptomycin monotherapy for serious enterococcal infections [ 171 ] suggesting that daptomycin may need to be combined with other antimicrobials for clinical cure, although clinical evidence to support this hypothesis is currently limited.…”

Section: Enterococcal Nvementioning

confidence: 99%

Endocarditis

2016

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“…Other series have shown worse results [120,124]. In a recent ICAAC, Ceron et al presented a 5-year study on daptomycin efficacy for enterococcal IE, with promising results [184]. Some successfully treated cases of multidrugresistant E. faecium endocarditis with daptomycin plus tigecycline combination have been reported [130,[134][135][136].…”

Section: Vancomycin-resistant Strainsmentioning

confidence: 99%

Enterococcal Endocarditis Revisited

et al. 2015

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The Enterococcus species is the third main cause of infective endocarditis (IE) worldwide, and it is gaining relevance, especially among healthcare-associated cases. Patients with enterococcal IE are older and have more comorbidities than other types of IE. Classical treatment options are limited due to the emergence of high-level aminoglycosides resistance (HLAR), vancomycin resistance and multidrug resistance in some cases. Besides, few new antimicrobial alternatives have shown real efficacy, despite some of them being recommended by major guidelines (including linezolid and daptomycin). Ampicillin plus ceftriaxone 2 g iv./12 h is a good option for Enterococcus faecalis IE caused by HLAR strains, but randomized clinical trials are essential to demonstrate its efficacy for non-HLAR EFIE and to compare it with ampicillin plus short-course gentamicin. The main mechanisms of resistance and treatment options are also reviewed for other enterococcal species.

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Efficacy of daptomycin in the treatment of enterococcal endocarditis: a 5 year comparison with conventional therapy

Cited by 27 publications

References 18 publications

Antimicrobial Treatment of Infective Endocarditis, Caused by <i>Enterococcus Faecalis

Antimicrobial Treatment of Infective Endocarditis, Caused by <i>Enterococcus Faecalis

Endocarditis

Enterococcal Endocarditis Revisited

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