Efficacy of Danshen (Salvia miltiorrhiza) Dripping Pills for Prevention of Acute Mountain Sickness: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract

Authors' Contribution RL and LG conceived and designed the study. RL, LG, JF, YH, ZS and SZ contributed to the preparation of the manuscript. LG, KL, LL, RL performed the trial. JF, YH, ZS prepared Figures 1-4. KL, LL, JF, YH and SZ prepared Tables and Figures S1-S3. All authors also read and approved the manuscript.

Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

“…In clinical trials, CDDP has been confirmed to maintain SO 2 and to decrease the incidence of AMS (Li et al. 2020 ). In the present study, the beneficial efficacy of CDDP in improving the adaptation to high altitude exposure was further evaluated through meta-analysis and the anti-hypoxic effects of CDDP pre-treatment were confirmed in a rat model of hypobaric hypoxia.…”

“…2012 ; Liu and Zhang 2017 ; Feng 2019 ; Li, Li, et al. 2020 ; Li, Guo, et al. 2020 ) involving 1051 patients were obtained.…”

“…Clinical studies indicate that CDDP can also improve oxygen saturation (SO 2 ) and prevent or relieve AMS-related symptoms as well as hypoxia-induced tissue damage (Li, Li, et al. 2020 ; Li, Guo, et al. 2020 ).…”