Efficacy of curcumin in the treatment of experimental vulvovaginal candidiasis

Andrade, Jéssica Tauany; Figueiredo, Geisa Fantini de; Cruz, Luisa Ferreira da; Morais, Sarah Eliza de; Souza, Carla Daiane Ferreira; Pinto, Flávia Carmo Horta; Ferreira, Jaqueline Maria Siqueira; Araújo, Marcelo Gonzaga de Freitas

doi:10.1016/j.riam.2019.01.003

Cited by 15 publications

(14 citation statements)

References 36 publications

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“…In the study of Wiench et al, the 635 nm diode laser alone is ineffective but PDT with toluidine blue significantly reduces all three species of C. albicans, C. glabrata, and C. krusei [49] . In the present reviewed study, three radiation wavelengths of 650, 405 and 532 nm of diode laser and LED alone, generally had no effect, but in combination with Cur (superior result), erythrosine and toluidine blue, it showed a fungicidal effect [28,[30][31][32] which is similar to findings of the other studies [43,[50][51][52] .…”

Section: Discussionsupporting

confidence: 88%

“…In four studies, PDT had a 100% reducing effect on C. albicans, C. dubliniensis, and C. tropicalis [27,29,31,32] , but this effect was not complete on C. glabrata [27,29] . Although C. glabrata has more resistance than C. albicans in the clinic [42] , but the present finding could be a bias because in other studies, for C. glabrata the minimum inhibitory concentration of Cur was higher than C. albicans and C. tropicalis [43,44] , and with increasing the concentration of Cur during PDT, its relative resistance may decrease [43,44] . Samples collected in the clinic may be more resistant to PDT than the pre-existing standard Candida spp.…”

Section: Discussioncontrasting

confidence: 57%

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Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Limoodi¹,

Khosraviani²,

Moghaddasi³

et al. 2021

Int. J. Appl. Dent. Sci.

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Introduction:In recent years, photodynamic therapy (PDT) has shown an effective role in controlling fungal infections such as oral candidiasis both in laboratory and clinical settings. Curcumin as a natural photosensitizer has antibacterial as well as antifungal effects. The aim of the present study was to evaluate the anti-Candida spp. effects of PDT by using curcumin. Methods: First, the intended keywords were searched in the four following databases: Google Scholar, PubMed, Scopus and Web of Science. The titles were then merged, and the original eligible articles published by the end of 2020 were scrutinized. Results: Out of 167 merged titles, 12 articles (In-vitro, in-vivo: mice & G. mellonella) met the required criteria and were included in the study. The studied Candida spp. were C. albicans, C. dubliniensis, C. glabrata and C. tropicalis. Concentrations of curcumin used in the studies ranged from 0.005 to 1000 µM. The light sources included LED (440-460 nm), diode laser (405, 532, 650 nm) and Xenon lamp (370-680 nm). The results of all studies showed that PDT reduced the colony count and the level of Candida spp. metabolism significantly. PDT efficacy was dependent on curcumin concentration, Candida spp., energy and wavelength of radiations, and it proved more effective in planktonic environments than biofilm environments. Conclusion: PDT using curcumin in a concentration-dependent manner has a potent lethal effect against some Candida spp. and may be considered as a major or adjuvant treatment for some Candida infections.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 57%

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Limoodi¹,

Khosraviani²,

Moghaddasi³

et al. 2021

Int. J. Appl. Dent. Sci.

View full text Add to dashboard Cite

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“…In addition, the safety of curcumin has been studied in animal models and human clinical trials, which have shown that its toxicity is low even when administered at high doses ( Bhavani Shankar et al., 1980 ; Qureshi et al., 1992 ). Previous studies using both biochemical, genetic or both approaches have shown that the curcumin exhibits antifungal activity against C. albicans via oxidative stress, inhibiting hyphal development, disrupting cell wall integrity and plasma membrane, modulates proteolytic enzyme activity, altering the membrane-associated properties of ATPase activity, modulating efflux pumps, synergizing with antifungal azoles, and inhibiting biofilm formation ( Sharma et al., 2009 ; Sharma et al., 2010a ; Sharma et al., 2010b ; Neelofar et al., 2011 ; Garcia-Gomes et al., 2012 ; Kumar et al., 2014 ; Lee and Lee, 2014 ; Shahzad et al., 2014 ; Thakre et al., 2016 ; Alalwan et al., 2017 ; Chen et al, 2018 ; Andrade et al., 2019 ; Hamzah et al., 2020 ; Cheraghipour et al., 2021 ; Dong et al, 2021 ; Lasrado et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Curcumin affects function of Hsp90 and drug efflux pump of Candida albicans

Lee

Chen

Widiyanto

et al. 2022

Front. Cell. Infect. Microbiol.

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Candida albicans is a pathogenic yeast that causes candidiasis in immunocompromised patients. The overuse of antifungal drugs has led to the development of resistance to such drugs by this fungus, which is a major challenge in antifungal chemotherapy. One approach to this problem involves the utilization of new natural products as an alternative source of antifungals. Curcumin, one such natural product, has been widely studied as a drug candidate and is reported to exhibit antifungal activity against C. albicans. Although studies of the mechanism of curcumin against human cancer cells have shown that it inhibits heat shock protein 90 (Hsp90), little is known about its function against C. albicans. In this paper, using a doxycycline-mediated HSP90 strain and an HSP90-overexpressing strain of C. albicans, we demonstrated that the curcumin triggered a decrease in Hsp90 by affecting it at the post-transcriptional level. This also led to the downregulation of HOG1 and CDR1, resulting in a reduction of the stress response and efflux pump activity of C. albicans. However, the inhibition of HSP90 by curcumin was not due to the inhibition of transcription factors HSF1 or AHR1. We also found that curcumin can not only decrease the transcriptional expression of CDR1, but also inhibit the efflux pump activity of Cdr1. Hence, we conclude that disruption of HSP90 by curcumin could impair cell growth, stress responses and efflux pump activity of C. albicans.

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“…The curcumin, which is obtained from rhizomes of the herb Curcuma longa L, containing polyphenolic compounds and which show antifungal, antimicrobial, antiinflammatory, antibacterial activity with less toxicity, less resistance and higher efficiency [4]. The Curcumin shows antifungal activity by a mechanism such as prevents hyphae growth by targeting TUP1, inducing oxidative stress, decrease ergosterol biosynthesis, and reducing the fungal exoenzymes aspartate proteases (SAP) [5].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

Bairagi

Patel

2021

Int J Curr Pharm Sci

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Objective: The main causative agent of vaginal candidiasis is Candida albicans and it develops resistance against several synthetic antifungal drugs and it has a high rate of infection in women. According to WHO report, around 75% of women are infected by Candida albicans and 50 % are infected a second time by Candida albicans. Therefore, we choose Curcumin an antifungal agent that had reported antifungal properties against the various fungal species. The Curcumin-containing emulgel based microemulsion system was prepared for greater retention time and penetration across the vaginal mucosa. Methods: The screening of oil phase, surfactant, and cosurfactant for microemulsion formulation was selected based on the solubility study and followed by the construction of the pseudoternary phase diagram. The oil phase, surfactant and co-surfactant are selected from the pseudoternary phase diagram for the formulation of a stable microemulsion. The prepared Curcumin-loaded microemulsion was characterized by globule size, polydispersity index, Zeta potential, accelerated stability study, drug content, percent transmittance and antifungal assay by broth microdilution technique. The formulated microemulsion was converted into a vaginal emulgel by using Pluronic@F127. The formulated curcumin-loaded emulgel was characterized by different evaluation parameters and antifungal study by agar well diffusion method. Results: The result showed that the average globule size of emulgel was 286.3 nm, polydispersity index was 0.241, Zeta potential was+19.20 mv, conductivity was 0.0390 mS/cm, and drug content was found to be 95.58%. The texture of formulated emulgel was found to be soft and smooth, with shear-thinning, pseudoplastic behavior, and easily spreadable. The in vitro permeability study of emulgel shows slow and complete release of curcumin in 10 h. The microemulsion and developed emulgel showed promising antifungal activity against Candida albicans. Conclusion: The developed curcumin-loaded emulgel showed promising antifungal activity against Candida albicans as compared to the Fluconazole as an standard antifungal antibiotic. Our formulated Curcumin-containing emulgel can be a potential alternative as compared to the conventional dosage form for the treatment of vaginal candidiasis.

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Efficacy of curcumin in the treatment of experimental vulvovaginal candidiasis

Cited by 15 publications

References 36 publications

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

Curcumin affects function of Hsp90 and drug efflux pump of Candida albicans

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

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