Efficacy of Crisis Intervention Treatment with Topical Corticosteroid Prednicarbat with and without Partial Wet-Wrap Dressing in Atopic Dermatitis

Abstract

Background: The wet-wrap treatment has been reported to be beneficial in acute episodes of atopic dermatitis (AD) skin lesions. Objective: The efficacy of topical corticosteroid prednicarbat with and without additional wet-wrap dressing was investigated in a prospective, randomized and controlled study. Methods: In the left-right comparison study, 24 adults and children with an acute episode of AD were included. One arm or leg was randomly treated with the topical corticosteroid prednicarbat plus wet-wrap dressing; only prednicarbat was applied on the leg or arm of the other side. Results: After 48–72 h of treatment, in both groups an improvement of the local SCORAD was observed. In comparison to the side of the body treated with corticosteroid alone, the decrease of the local SCORAD in the corticosteroid plus wet-wrap dressing group was significantly better. The severity of AD improved in the wet-wrap group at an average of 4.4 points, in the corticosteroid group 3.0 (p < 0.011). Conclusions: Wet-wrap therapy with a topical corticosteroid is an effective treatment option in patients with exacerbated AD. The treatment is helpful in improving skin conditions, shortening the time of corticosteroid application.

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

“…Another way of providing a corticosteroid spare could be to use wet-wrap dressing in combination with emollient as adjunctive treatment in the management of AD, as it has been demonstrated that this combination was able to significantly reduce disease severity in patients with AD compared to a topical corticosteroid treatment alone [29]. …”

Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report

“…A wet layer of cotton dressing, which is then covered with tubular bandages applied over emollients 141 in combination with antiseptics or topical steroids, 142 has been shown to be beneficial in cases of exacerbated AD skin lesions. 143 A more practical alternative approach using clothing rather than bandages has also been described in detail. 144 Topical antimicrobial therapy.…”

Atopic Dermatitis: an Update and Review of the Literature

“…A wet layer of cotton dressing in combination with antiseptics or topical steroids (TCs) has been shown to be beneficial in cases of exacerbated AD skin lesions (10,38).…”