Efficacy of covering mucosal defects with polyglycolic acid sheets after ear or nose surgery

Ota, Yasushi; Ikemiyagi, Yoshihiro; Takizawa, Kenji; Yamada, Chikashi; Rikitake, Ryoko; Suzuki, Michitaka

doi:10.1002/lary.24978

Cited by 2 publications

(3 citation statements)

References 10 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spongel ® is used in clinical situations to promote hemostasis and regeneration of the olfactory epithelium by placing it in the olfactory clefts with drugs. [17][18][19]32,33 Spongel ® is relatively inexpensive and supposed to be associated with little foreign body reaction, 34 but it adheres strongly to the wound and remains in place for approximately 1 month. 35 Packing materials are known to cause toxicity, foreign body reactions, and inflammation when left in the nose for an extended period 7,11 ; Therefore, Spongel ® is expected to cause inflammation and impair wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Algoderm® is composed of calcium alginate acid, and Nasopore® is composed of polyurethane. Spongel® is used in clinical situations to promote hemostasis and regeneration of the olfactory epithelium by placing it in the olfactory clefts with drugs 17–19,32,33 . Spongel® is relatively inexpensive and supposed to be associated with little foreign body reaction, 34 but it adheres strongly to the wound and remains in place for approximately 1 month 35 .…”

Section: Discussionmentioning

confidence: 99%

“…Mucosal defects were created in their nasal septum and histologically investigated the effects of different packing materials and replacement periods on wound healing. Three packing materials were selected for this animal study: Spongel ® (gelatin sponge, LTL Pharma Co., Ltd., Tokyo, Japan), composed of gelatine that remains in the wound for a long time and is mainly used for haemostasis [17][18][19] ; Algoderm ® (calcium alginate fiber, Smith+Nephew, London, UK), a wound dressing material composed of alginate that dissolves with exudate and blood 14,20 ; and Nasopore ® (polyurethane foam, Stryker, Kalamazoo, MI), composed of synthetic polyurethane, can be hydrolyzed, and dissolves after maintaining its shape and compressing the wound for few days. 9,12,21,22…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nasal Packing Materials and Placement Duration on Wound Healing in Nasal Mucosa: An Animal Study

et al. 2023

View full text Add to dashboard Cite

ObjectiveThe histological findings of wound healing depending on different nasal packing materials and replacement periods were lacking.MethodsMucosal defects were created in the nasal septum of rabbits and covered with Spongel®, Algoderm®, or Nasopore®, which were cleaned on Day 14. To investigate the effect of replacement durations, Spongel® was removed on Days 3 and 7. All nasal septal specimens were collected on Day 28. Samples without packing material were prepared as controls. Depending on residual packing materials in the regenerated tissue, specimens were classified into the remnant and non‐remnant groups, and morphology was compared using epithelium grade score and subepithelial thickness.ResultsThe epithelium grade score in the Spongel‐14d group was lower than that in the other groups (p < 0.05). Subepithelial thickness was higher in the Algoderm‐14d and Spongel‐14d groups (p < 0.05). Epithelium grade scores were higher and subepithelial thicknesses were lower in the Spongel‐3d and ‐7d groups than in the Spongel‐14d group. Epithelium grade score was lower and subepithelial thickness was higher in the remnant group (n = 10) than in the non‐remnant group (n = 15; p < 0.05).ConclusionsDifferences in packing materials and placement durations affected wound healing of nasal mucosa. The selection of appropriate packing materials and replacement duration was considered essential for ideal wound healing.Level of EvidenceNA Laryngoscope, 2023

show abstract