Efficacy of Contrast-Enhanced Ultrasound Washout Rate in Predicting Hepatocellular Carcinoma Differentiation

Feng, Yan; Qin, Xiachuan; Luo, Yan; Li, Yongzhong; Zhou, Xiang

doi:10.1016/j.ultrasmedbio.2015.01.026

Cited by 42 publications

(27 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histological methods such as biopsies are invasive and not generally accepted by patients. Imaging parameters, including contrast-enhanced ultrasound washout rate and apparent diffusion coefficient value, are related to HCC differentiation grades (21,22), but remain unsatisfactory.…”

Section: Discussionmentioning

confidence: 99%

Metabolic profiling of hepatitis B virus-related hepatocellular carcinoma with diverse differentiation grades

et al. 2017

View full text Add to dashboard Cite

The most effective diagnostic tool for the majority of hepatocellular carcinoma (HCC) patients is determining the differentiation grade of their tumors. However liver biopsies, which are currently the most effective way of determining tumor differentiation grade, have several limitations. The present study was designed to select serum characteristic metabolites that correlate with the differentiation grades of hepatitis B virus (HBV)-related HCC, and so could be used in the clinic as a non-invasive method of differentiating patients with different grades of HCC. A total of 58 patients with HBV-related HCC were included in the present study, and divided into three groups according to their tumor differentiation grade. A further 20 patients with HBV-related liver cirrhosis and 19 healthy volunteers were enrolled. Ultra-performance liquid chromatography-mass spectrometry was used to analyze endogenous metabolites. Multivariate statistical analysis was used to examine the data using MZmine 2.0 software. The 14 metabolites that were highly correlated with specific differentiation grades of HCC were then selected for additional study. Receiver operator characteristic curve analysis was used to evaluate their clinical value. In total, 5 metabolites were finally identified, including lysophosphatidylcholine (16:0), oleamide, monoglyceride (0:0/15:0/0:0), lysophosphatidylcholine (18:0) and lysophosphatidylcholine [22:5(7Z,10Z,13Z,16Z,19Z)]. All these metabolites exhibited an excellent ability to distinguish different types of HCC with various differentiation grades and the area under the curve of these metabolites was up to 0.942, showing promising clinical value.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic profiling of hepatitis B virus-related hepatocellular carcinoma with diverse differentiation grades

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Typical imaging features of lesions found in that study included: mean attenuation of 36 Hounsfield units (30-45) by CT, heterogeneous foci of hypervascular enhancement on late arterial phase, and continued expansion of these foci during the portal venous phase. This differentiates the lesion from hepatocellular carcinoma which typically will display delayed washout, also seen on MR [4]. The remainder of the lesion beyond these foci is comparable with blood attenuation, consistent with the known hemorrhagic nature of this tumor [3].…”

Section: Discussionmentioning

confidence: 69%

Primary Hepatic Angiosarcoma Mimicking Multifocal Liver Abscess with Disseminated Intravascular Coagulation and Hemoperitoneum

Rowe

Nehme

Wallace

et al. 2017

Cureus

View full text Add to dashboard Cite

Primary hepatic angiosarcoma (PHA), a rare and aggressive malignancy, has rarely been reported to present with disseminated intravascular coagulation with liver hemorrhage. Incidence is estimated at 0.5–2.5 cases per 10,000,000. To our knowledge, it has not been reported to mimic liver abscess with a septic presentation. Advanced imaging techniques may aid in the diagnosis, though biopsy with microscopy and immunohistochemistry is the mainstay. Prognosis is very poor, with a 5-year survival rate estimated at 6.4%. We present the case of a 70-year-old man who presented with sepsis thought to be due to a multifocal liver abscess, who did not respond to drainage and antibiotics. This atypical course led to further workup which subsequently revealed a diagnosis of PHA.

show abstract

“…With CEUS, the vascularity of a lesion is evaluated based on (1) the degree and pattern of arterial phase enhancement and (2) the presence or absence and degree of wash‐out in later phase . In our series, all lesions were hyperenhanced in arterial phase as compared to the surrounding parenchyma with no case of isoenhancement or hypoenhancement and all HCC lesions were hypoenhanced in postvascular phase (up to 600 seconds after injection).…”

Section: Discussionmentioning

confidence: 95%

“…The washout in postvascular phase is highly suggestive of malignancy. [20][21][22] CEUS contributes to the diagnosis of HCC in normal liver by confirming the lesions hypervascularity in arterial phase, and show the washout in postvascular phase.…”

Section: Discussionmentioning

confidence: 99%

“…In our series, all lesions were hyperenhanced in arterial phase as compared to the surrounding parenchyma with no case of isoenhancement or hypoenhancement and all HCC lesions were hypoenhanced in postvascular phase (up to 600 seconds after injection). The wash‐out in postvascular phase is highly suggestive of malignancy . CEUS contributes to the diagnosis of HCC in normal liver by confirming the lesions hypervascularity in arterial phase, and show the wash‐out in postvascular phase.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatocellular carcinoma in otherwise sonographically normal liver

Naganuma¹,

Ishida

Ogawa

et al. 2018

J of Clinical Ultrasound

View full text Add to dashboard Cite

Purpose Hepatocellular carcinoma (HCC) on normal liver is very rare. The goal of this study was to determine the clinical manifestations and the role of ultrasonography (US) in the diagnosis of HCC arising in normal liver. Methods The clinical data and US findings in 12 cases of surgically resected HCC in normal liver were retrospectively analyzed. Results The patients were asymptomatic, had no hepatocarcinogenic factor, and hepatic function tests were almost normal in most cases. HCCs were large, encapsulated, and solitary, and there were predominantly well‐differentiated or moderately differentiated in most cases. US showed a hypoechoic rim and lateral shadowing, suggestive of peritumoral capsule formation, and on contrast‐enhanced US (CEUS), the tumor was hyperenhanced in arterial phase and washed out in postvascular phase, revealing typical HCC findings. Conclusions US raises suspicion of HCC by showing lateral shadowing on grayscale ultrasound and hypervascularity on CEUS of the lesion.

show abstract

Efficacy of Contrast-Enhanced Ultrasound Washout Rate in Predicting Hepatocellular Carcinoma Differentiation

Cited by 42 publications

References 46 publications

Metabolic profiling of hepatitis B virus-related hepatocellular carcinoma with diverse differentiation grades

Metabolic profiling of hepatitis B virus-related hepatocellular carcinoma with diverse differentiation grades

Primary Hepatic Angiosarcoma Mimicking Multifocal Liver Abscess with Disseminated Intravascular Coagulation and Hemoperitoneum

Hepatocellular carcinoma in otherwise sonographically normal liver

Contact Info

Product

Resources

About