Efficacy of continuous theta burst stimulation of the primary motor cortex in reducing migraine frequency: A preliminary open-label study

Chen, Pei-Ru; Lai, Kuan‐Lin; Fuh, Jong‐Ling; Chen, Shih‐Pin; Wang, Pei‐Ning; Liao, Kwong‐Kum; Wang, Shuu Jiun

doi:10.1016/j.jcma.2015.10.008

Cited by 16 publications

(31 citation statements)

References 29 publications

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“…The lower quality studies demonstrated evidence of selection, performance, detection, and attrition bias (Table ). Despite this, there were reported decreases in headache frequency and intensity using sTMS, cTBS, and dTMS technologies.…”

Section: Resultsmentioning

confidence: 99%

“…There were a total of 34 studies included in the descriptive synthesis. Of those, 22 were TMS (16 rTMS) and 12 were tDCS articles (Supplementary Materials – Study Characteristics Tables). A comparison of defining study parameters is outlined below.…”

Section: Resultsmentioning

confidence: 99%

“…Twelve TMS studies (9 rTMS, 2 sTMS, and 1 dTMS) were randomized trials. The remaining 10 were either non‐randomized controlled or prospective cohort/open label trials . Baseline duration among studies ranged from 1 day to 4 weeks, treatment duration varied from 1 day to 3 months, with 4 weeks being most common.…”

Section: Resultsmentioning

confidence: 99%

“…The other TMS studies included 4 single‐pulse TMS (sTMS), 1 deep TMS (dTMS), and 1 continuous theta burst stimulation (cTBS). Of those, 1 was high quality (low risk of bias), 1 moderate quality (uncertain risk of bias), and 4 low quality (high risk of bias) …”

Section: Resultsmentioning

confidence: 99%

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Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review

et al. 2019

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Background Headache is among the most prevalent causes of disability worldwide. Non‐pharmacologic interventions, including neuromodulation therapies, have been proposed in patients who are treatment resistant or intolerant to medications. Objective To perform a systematic review on the use of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for the treatment of specific headache disorders (ie, migraine, tension, cluster, posttraumatic). Methods Data sources: Ovid MEDLINE, Cochrane Central Register of Clinical Trials, Embase, Scopus, PsycINFO. Data extraction: All references were reviewed by 2 independent researchers (3039 abstracts, duplicates removed). Records were selected by inclusion criteria for participants (adults 18‐65 with primary or secondary headaches), interventions (TMS and tDCS applied as headache treatment), comparators (sham or alternative standard of care), and study type (cohort, case‐control, and randomized controlled trials [RCT]). Studies were assessed using the Cochrane Risk of Bias Tool and overall quality determined through the GRADE Tool. A structured synthesis was performed due to heterogeneity of participants and methods. Results Thirty‐four studies were included: 16 rTMS, 6 TMS (excluding rTMS), and 12 tDCS. The majority investigated treatment for migraine (19/22 TMS, 8/12 tDCS). Quality of evidence ranged from very low to high. Conclusion Of all TMS and tDCS modalities, rTMS is most promising with moderate evidence that it contributes to reductions in headache frequency, duration, intensity, abortive medication use, depression, and functional impairment. However, only few studies reported changes greater than sham treatment. Further high‐quality RCTs with standardized protocols are required for each specific headache disorder to validate a treatment effect. Registration Number: PROSPERO 2017 CRD42017076232.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review

et al. 2019

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“…It is also relevant to consider that there are some articles that did not use sham comparator to demonstrate NIBS efficacy on pain control in migraineurs, similarly to previous medication studies . Thus, the development of more randomized controlled clinical trials is necessary for future researches.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Noninvasive Brain Stimulation on Pain Control in Migraine Patients: A Systematic Review and Meta‐Analysis

et al. 2016

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Low or very low quality of evidence suggests that our primary outcome evaluation failed to find support for the superiority of NIBS over sham treatment. Although, subgroup analysis reveals that tDCS have moderate to high effects and could be a promising nonpharmacological alternative to pain control, mainly for painkiller intake reduction. However, there is a need for larger controlled trials with methodological rigor, which could increase the power of result inference.

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Repetitive Transcranial Magnetic Stimulation

Brighina

Fierro

Cosentino

2019

Neuromodulation in Headache and Facial Pain Management

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Efficacy of continuous theta burst stimulation of the primary motor cortex in reducing migraine frequency: A preliminary open-label study

Abstract: Our results indicate that cTBS on the primary motor cortex might reduce the number of total headache and migraine days in patients with migraine. However, large-scale randomized controlled trials are necessary to further validate the findings.

Cited by 16 publications

References 29 publications

Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review

Transcranial Magnetic and Direct Current Stimulation (TMS/tDCS) for the Treatment of Headache: A Systematic Review

Efficacy of Noninvasive Brain Stimulation on Pain Control in Migraine Patients: A Systematic Review and Meta‐Analysis

Repetitive Transcranial Magnetic Stimulation

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