Efficacy of Concomitant Therapy with Fluoride and Chlorhexidine Varnish on Remineralization of Incipient Lesions in Young Children

Abstract

AimTo assess the effect of combined use of chlorhexidine and fluoride varnish on the remineralization of incipient carious lesions in young children.Materials and methodsTwenty caries-active children (80 lesions) were randomly divided into four groups and subjected to initial examination. Caries status was assessed visually and with the aid of DIAGNOdent. Baseline enamel biopsies were obtained. Subjects of groups I and II received fluoride and chlorhexidine varnish respectively. Group III received both fluoride and chlorhexidine varnish alternatively, for a period of 4 weeks. Group IV served as the control. At 3-month follow-up, the incipient lesions were assessed again with DIAGNOdent and enamel biopsy.ResultsIncreased calcium, phosphate, and fluoride levels were noticed in groups I, II, III compared to group IV, at the 3-month follow-up (p < 0.001).ConclusionThe combined therapy with fluoride and chlorhex-idine varnish may be considered an alternative therapy for early reversal of incipient lesions.How to cite this articleNaidu S, Tandon S, Nayak R, Ratnanag PV, Prajapati D, Kamath N. Efficacy of Concomitant Therapy with Fluoride and Chlorhexidine Varnish on Remineralization of Incipient Lesions in Young Children. Int J Clin Pediatr Dent 2016;9(4):296-302.

Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis

“…It restores the mineral content that was lost during the active caries process through remineralization and makes the hard tissues more resistant to demineralization in future pH drops [Byeon et al, 2016;Naidu et al, 2016]. Similarly, partial caries removal followed by ART restorations with GIC controls caries progression by providing proper conditions for the reorganization of the carious dentin left at the cavity floor.…”

<p>Daya antibakteri asam palmitat bawang putih (Allium sativum) terhadap Streptococcus mutans ATCC 25175</p><p>Antibacterial activity of garlic (Allium sativum) palmitic acid towards Streptococcus mutans ATCC 25175</p>

“…Klorheksidin dapat terikat dengan mudah pada dinding sel bakteri Gram negatif dan dengan mudah menghancurkan integritas membran sel bakterinya. 9 Klorheksidin dengan konsentrasi tinggi bersifat bakterisidal dan mekanisme kerjanya tampak seperti deterjen karena merusak membran sel bakteri. 9 Hasil yang didapatkan pada penelitian ini menunjukkan bahwa asam palmitat bawang putih dengan konsentrasi 0,5%-12% tidak dapat menghambat pertumbuhan bakteri Streptococcus mutans ATCC 25175.…”

“…9 Klorheksidin dengan konsentrasi tinggi bersifat bakterisidal dan mekanisme kerjanya tampak seperti deterjen karena merusak membran sel bakteri. 9 Hasil yang didapatkan pada penelitian ini menunjukkan bahwa asam palmitat bawang putih dengan konsentrasi 0,5%-12% tidak dapat menghambat pertumbuhan bakteri Streptococcus mutans ATCC 25175. Tidak adanya zona hambat asam palmitat bawang putih dikarenakan zat aktif yang digunakan.…”

Intraoral slow-releasing polymeric patches containing sodium fluoride and chlorhexidine: Development and evaluation

“…Early childhood caries (ECC) has been considered to be at epidemic proportions in developing countries (Weinstein et al, 1994). The consequences of untreated ECC can affect both the immediate and long-term quality of life of the child (Inglehart et al, 2002). This chronic infectious disease of childhood is caused by the interaction of bacteria, mainly Streptococcus mutans, and sugary foods on tooth enamel (Colak et al, 2013).…”