Efficacy of components from leaves of Calophyllum brasiliense against Leishmania (Leishmania) amazonensis

Honda, Paula Akemi; Ferreira, Izabel Cristina Piloto; Cortez, D. A. G.; Amado, Ciomar Aparecida Bersani; Silveira, Thaís Gomes Verzignassi; Brenzan, Mislaine Adriana; Lonardoni, Maria Valdrinez Campana

doi:10.1016/j.phymed.2009.08.011

Cited by 26 publications

(21 citation statements)

References 20 publications

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“…However, some extracts from other species of the genus Calophyllun have been evaluated against Leishmania and other microorganisms. The dichloromethane crude extract from leaves of C. brasiliense showed a significant in vitro (Honda et al, 2010;Brenzan et al, 2007) and in vivo activity against L. amazonensis (Honda et al, 2010). A coumarin was isolated from this extract and its derivatives showed significant activity against L. amazonensis, with IC 50 between 0.6 and 34.0 µg/mL (Brenzan et al, 2007;Brenzan et al, 2008).…”

Section: Resultsmentioning

confidence: 93%

Antileishmanial activity of leaf extract from Calophyllum rivulare against Leishmania amazonensis

Oubada

García

Bello

et al. 2014

Emir. J. Food Agric

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Calophyllum rivulare is an endemic tree from Cuba that belongs to Clusiaceae family. This plant had revealed it to be a rich source of pyranochromanone acids including compounds with a variety of biological potentialities such as antioxidant, antiulcer, anticancer and anti-Helicobacter pylori activities. Herein, antileishmanial and cytotoxic activities of extracts obtained from C. rivulare leaves (rich in pyranochromanone acids) and amentoflavone were compared. Extracts were prepared by maceration employing ethyl acetate (CR-1) and methanol (CR-2) as solvents and amentoflavone was isolated from both extracts. The CR-2 extract showed the better activity against the parasite, with an IC 50 value of 95.1 ± 5.4 µg/mL and 20.6 ± 1.4 µg/mL against promastigote and amastigote forms, respectively. This extract showed lower cytotoxicity (IC 50 =182.4 ± 2.3 µg/mL) against peritoneal macrophage from BALB/c mice and a selectivity index of 9. Amentoflavone showed an IC50 of 5.9 ± 0.3 µg/mL against amastigote form and a selectivity index of 9. Results suggest that CR-2 extract and amentoflavone could be explored as new antileishmanial alternatives.

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Section: Resultsmentioning

confidence: 93%

Antileishmanial activity of leaf extract from Calophyllum rivulare against Leishmania amazonensis

Oubada

García

Bello

et al. 2014

Emir. J. Food Agric

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“…Compounds isolated from the leaves of Calophyllum brasiliense were effective against T . cruzi , the etiologic agent of Chagas' disease (Abe et al ., ), and against Leishmania amazonensis that can cause cutaneous leishmaniasis (Honda et al ., ). In our study, the resin of C .…”

Section: Microorganisms and Cellsmentioning

confidence: 97%

Antimicrobial Assessment of Resins fromCalophyllum AntillanumandCalophyllum Inophyllum

et al. 2015

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The Calophyllum genus is well-known for its antimicrobial and cytotoxic activities, and therefore, we analyzed these biological activities for resins of Calophyllum antillanum and Calophyllum inophyllum growing in Cuba. C. antillanum resins showed a potent activity against Plasmodium falciparum (IC50 = 0.3 ± 0.1 µg/mL), while its cytotoxicity against MRC-5 cells was much lower (IC50 = 21.6 ± 1.1 µg/mL). In contrary, the resin of C. inophyllum showed an unspecific activity. The presence of apetalic acid, isoapetalic acid, calolongic acid, pinetoric acid I, pinetoric acid II, isocalolongic acid, pinetoric acid III, and isopinetoric acid III in C. antillanum resins was also confirmed. These results demonstrated for the first time the potential activity of C. antillanum resins against P. falciparum.

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“…13 The inhibitory concentration of 50% of the parasites (IC 50 ) was calculated by linear regression equation. 13 Peritoneal macrophages BALB/c mice were infected with L. amazonensis promastigotes (6 parasites/ macrophage) as in Honda et al 14 Photosensitizers RBMET (8. 7 mM) and RBBUT (17.2 mM) were diluted in twofold, the protocol of incubation and illumination was the same as described above.…”

Section: Illumination Systemmentioning

confidence: 99%

Photodynamic Therapy With Bengal Rose and Derivatives Against Leishmania amazonensis

et al. 2017

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Introduction: The treatment of cutaneous leishmaniasis (CL) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. Photodynamic therapy (PDT) is an alternative for the treatment of CL, and some xanthene dyes have the potential for use in PDT. Methods: The xanthenes rose bengal B (RB) and its derivatives rose bengal methyl ester (RBMET), and butyl ester (RBBUT) were analyzed for leishmanicidal activity against promastigotes and intracellular amastigotes of Leishmania amazonensis. Cytotoxicity was assessed in J774.A1 macrophages. Results: RB derivates RBMET (IC 50 9.83 µM), and RBBUT (IC 50 45.08 µM) showed leishmanicidal activity, however, were toxic to J774.A1 macrophages, resulting in low selectivity index. Conclusion:The RBMET and RBBUT showed to be effective against the L. amazonensis and the low selectivity index presented may not be a limitation for their use in PDT to CL treatment.

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Efficacy of components from leaves of Calophyllum brasiliense against Leishmania (Leishmania) amazonensis

Cited by 26 publications

References 20 publications

Antileishmanial activity of leaf extract from Calophyllum rivulare against Leishmania amazonensis

Antileishmanial activity of leaf extract from Calophyllum rivulare against Leishmania amazonensis

Antimicrobial Assessment of Resins fromCalophyllum AntillanumandCalophyllum Inophyllum

Photodynamic Therapy With Bengal Rose and Derivatives Against Leishmania amazonensis

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