Efficacy of Complex Antioxidant Energy Correction of Different Durations in the Treatment of Cerebral Infarction (results of a multicenter randomized study)

Rumyantseva, S. A.; Коваленко, А. Л.; Silina, Ekaterina; Stupin, Victor; Кабаева, Е. Н.; Chichanovskaya, L. V.; Nazarov, Mikhail; Цукурова, Л А; Burenichev, D. V.; Golikov, K. V.; Salnikov, M. V.; Belova, L. A.; Машин, В В; Mazina, N. K.; Zhilina, E. A.; Kolotik-Kameneva, O Yu; Sherman, Marika

doi:10.1007/s11055-017-0395-1

Cited by 7 publications

(5 citation statements)

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“…In addition to a high dose of succinate (1000 mg in an ampoule of 10 mL), cytoflavin contains coenzymes nicotinamide, riboflavin, and inosine (riboxin), stimulating glucose-pyruvate transformations in the Krebs cycle. The preparation of cytoflavin has an evidentiary base that objectifies its positive effect on the clinical course and on the volume of foci of ischemia (Rumyantseva et al 2017;Odinak et al 2010). This makes it expedient to use it in the early period of the HS.…”

Section: Discussionmentioning

confidence: 99%

Early predictive blood markers of hemorrhagic stroke — influence of cytoflavin therapy

Silina

Rumyantceva

Stupin

et al. 2021

Can. J. Physiol. Pharmacol.

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Examination of the patterns of free-radical processes (FRP) and changes of the early screening markers to predict the course of hemorrhagic stroke (HS) and applied pathophysiologically based therapy, can be of great practical importance. This study aimed to determine early changes in the parameters of oxidative stress and routine biochemistry blood tests in patients with HS and to assess their relationship with clinical outcome. The effects of early applied cytoflavin were also investigated. The prospective study included 151 patients with HS. 48% of patients in the standard conservative therapy was added cytoflavin antioxidant energy therapy from the first day of hospitalization. The neurological status, neuroimaging, biochemical blood tests and free radical processes were assessed on days 1, 5, 10, 20 of hospitalization. In patients with HS, an imbalance of all stages of FRP was detected proportionately to the severity of HS. The MDA concentration above 5.3 μmol/l, the number of leukocytes above 15.8 thousand, glucose above 11.9 mmol/l, lactate dehydrogenase above 574 IU/l, lactate above 2.5 mmol/l, detected on the 1st day, predetermined a high risk of death. Additional cytoflavin treatment allowed stabilizing the clinical-laboratory picture of HS, improved the treatment results and reduced hospital mortality rate.

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Section: Discussionmentioning

confidence: 99%

Early predictive blood markers of hemorrhagic stroke — influence of cytoflavin therapy

Silina

Rumyantceva

Stupin

et al. 2021

Can. J. Physiol. Pharmacol.

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“…The reason for the pharmacological effect of Cytoflavin is the complex influence of its components. A number of works show that Cytoflavin improves coronary and cerebral blood flow and activates metabolic processes in the central nervous system …”

Section: Discussionmentioning

confidence: 99%

“…In this study, Cytoflavin® (POLYSAN Scientific & Technological Pharmaceutical Company, Saint Petersburg, Russian Federation) was used as a reduction agent. It is currently used for the treatment of cardiovascular disease, and positive results have also been obtained in vivo . The purpose of this study is to show the change in the spectrin matrix and red blood cell morphology during the processes of haemoglobin oxidation to methaemoglobin and reduction to oxyhaemoglobin.…”

Section: Introductionmentioning

confidence: 99%

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Atomic force microscopy study of red blood cell membrane nanostructure during oxidation‐reduction processes

Козлова

Черныш

Сергунова

et al. 2018

J of Molecular Recognition

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The morphology and functional state of red blood cells (RBCs) mainly depends on the configuration of the spectrin network, which can be broken under the influence of intoxication because of oxidation processes in the cells. Measurement of these processes is a complex problem. The most suitable and prospective method that resolves this problem is atomic force microscopy (AFM). We used AFM to study the changes in the spectrin matrix and RBC morphology during oxidation processes caused by ultraviolet (UV) irradiation in RBC suspension. The number of discocytes decreased from 98% (in control) to 12%. We obtained AFM images of the spectrin matrix in RBC ghosts. Atomic force microscopy allows for the direct observation and quantitative measurement of the disturbances in the structure of the spectrin matrix during oxidation processes in RBCs. The typical section size of the spectrin network changed from approximately 80 to 200 nm (in control) to 600 nm and even to 1000 nm after UV irradiation. An AFM study showed that incubation of RBCs with Cytoflavin® after UV irradiation preserved the forms of RBCs almost at control levels; 89% of the cells remained as discocytes. To quantify the intensity of the oxidation-reduction processes, the percentage of haemoglobin derivatives was measured. The content of methaemoglobin varied in the range of 1% to 70% during the experiments. These evidence-based studies are important for the fundamental research of interactions during redox processes in RBCs at the molecular level.

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“…Это метаболический цитопротектор, антигипоксант, антиоксидант и энергокорректор, активизирующий энергообразование и дыхание в клетках, восстанавливающий активность факторов антиоксидантной защиты организма, повышающий способность клеток утилизировать глюкозу и кислород, стимулирующий синтез белка внутри клеток, через шунт Робертса способствующий ресинтезу в нейронах гамма-аминомасляной кислоты и участвующий в процессе быстрой утилизации жирных кислот. Благодаря этим эффектам происходят улучшение коронарного и мозгового кровотока, стабилизация метаболической активности центральной нервной системы, восстановление интеллектуально-мнестических функций, сознания, регресс расстройств чувствительности и нарушений рефлекторной деятельности [50,51]. Использование Цитофлавина в острейшем периоде ИИ способствует более полному восстановлению нарушенных неврологических функций [1, [52][53][54].…”

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Ischemic Stroke and COVID-19: A Literature Review

Наумова¹,

Прусакова²,

Наумов³

2022

Неврология И Нейрохирургия. Восточная Европа

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Целью работы являлся обзор литературы об экспериментальных и клинических исследованиях, отражающих патогенетическую роль возможного использования сукцинатов в коррекции гипоксии при ишемическом инсульте и COVID-19. Было проанализировано 57 зарубежных и отечественных литературных источников, касающихся роли Цитофлавина в лечении гипоксии при ишемическом инсульте и COVID-19. Анализ литературы показал, что в основе патогенеза COVID-19 и ишемических поражений головного мозга лежит гипоксия тканей, запускающая весь каскад патоморфологических событий, приводящих к развитию полиорганной недостаточности. В экспериментальных и клинических исследованиях отражен положительный эффект коррекции гипоксии тканей с использованием такого сукцината, как Цитофлавин. Назначение Цитофлавина приводит к лучшей и опережающей группу сравнения динамике неврологического, функционального и когнитивного статуса. Таким образом, по результатам проведенного анализа отечественной и зарубежной литературы выявлены высокая частота и полиморфность симптомов поражения ЦНС, а также важная роль сосудистого поражения головного мозга и нейродегенерации в патогенезе COVID-19. The purpose of the work was to review the literature on experimental and clinical studies reflecting the pathogenetic role of the possible use of succinate in correction of hypoxia in ischemic stroke and COVID-19. 57 foreign and domestic literature sources regarding the role of Cytoflavin in hypoxia management in ischemic stroke and COVID-19 were analyzed. The analysis of the literature showed that the underlying the pathogenesis of COVID-19 and ischemic brain lesions is tissue hypoxia, triggering the whole cascade of pathomorphological events leading to the development of multiple organ failure. Both experimental and clinical studies reflect the positive effect of tissue hypoxia correction with the use of such succinate as Cytoflavin. The administration of Cytoflavin results in better and outpacing the comparison group dynamics of neurological, functional and cognitive status. Thus, the results of the analysis of domestic and foreign literature revealed a high incidence and polymorphism of CNS lesion symptoms, as well as an important role of cerebral vascular lesions and neurodegeneration in COVID-19 pathogenesis.

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Efficacy of Complex Antioxidant Energy Correction of Different Durations in the Treatment of Cerebral Infarction (results of a multicenter randomized study)

Cited by 7 publications

References 1 publication

Early predictive blood markers of hemorrhagic stroke — influence of cytoflavin therapy

Early predictive blood markers of hemorrhagic stroke — influence of cytoflavin therapy

Atomic force microscopy study of red blood cell membrane nanostructure during oxidation‐reduction processes

Ischemic Stroke and COVID-19: A Literature Review

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