Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by <i>Angiostrongylus cantonensis</i> in mice

He, Hailong; Lv, Ziquan; Li, Zhengyu; Zhang, Liyan; Liao, Qi; Zheng, Haixue; Su, Weiyang; Rao, Shaoqi; Yu, Xiaoli; Wu, Zhongdao

doi:10.1017/s0022149x10000337

Cited by 16 publications

(15 citation statements)

References 34 publications

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“…The combination of corticosteroids and anthelminthics has been commonly used for treatment of human angiostrongyliasis ( [62], and also see review in Wang et al [2]). Currently, some Chinese herbal medicines display efficacy for treating angiostrongyliasis in animal studies but have not been used in humans [63][64][65][66][67]. Surgery is required to remove worms from the eyes of patients with ocular angiostrongyliasis.…”

Section: Treatmentmentioning

confidence: 98%

Human Angiostrongylus cantonensis: an update

Wang

Wei

et al. 2011

Eur J Clin Microbiol Infect Dis

184

146

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Angiostrongylus cantonensis was first discovered in 1935 and has become an important emerging pathogen causing human angiostrongyliasis. Major outbreaks of human angiostrongyliasis have been reported in endemic regions. Thousands of cases of human angiostrongyliasis have been documented worldwide. A. cantonensis has spread from its traditional endemic regions of the Pacific islands and Southeast Asia to the American continent including the USA, Caribbean islands and Brazil. Humans acquire A. cantonensis by consumption of raw or undercooked intermediate snail hosts or paratenic hosts. The main clinical manifestations of human angiostrongyliasis are eosinophilic meningitis and ocular angiostrongyliasis. The treatment of this disease includes supportive treatment, corticosteroid therapy, and combined therapy with corticosteroids and anthelminthics. The most effective method for prevention is to persuade people not to eat raw or undercooked intermediate and paratenic hosts.

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Section: Treatmentmentioning

confidence: 98%

Human Angiostrongylus cantonensis: an update

Wang

Wei

et al. 2011

Eur J Clin Microbiol Infect Dis

184

146

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“…The combination regimen was also used in the outbreak in Taiwan (Tsai et al 2001). The combination of albendazole with other agents, such as thalidomide (Chen and Lai 2007), dexamethasone (Tu and Lai 2006) or interleukin (Du et al 2003), and traditional Chinese medicine baicalein (He et al 2011) was also studied. The researchers expected the anti-inflammatory effect of the additional medications could help anthelminthics alleviate CNS inflammatory.…”

Section: Discussionmentioning

confidence: 99%

Microglia activation: one of the checkpoints in the CNS inflammation caused by Angiostrongylus cantonensis infection in rodent model

Wei

et al. 2015

Parasitol Res

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Angiostrongylus cantonensis (A. cantonensis) is a rodent nematode. Adult worms of A. cantonensis live in the pulmonary arteries of rats; humans are non-permissive hosts like the mice. The larva cannot develop into an adult worm and only causes serious eosinophilic meningitis or meningo-encephalitis if humans or mice eat food containing larva of A. cantonensis in the third stage. The differing consequences largely depend on differing immune responses of hosts to parasite during A. cantonensis invasion and development. To further understand the reasons why mice and rats attain different outcomes in A. cantonensis infection, we used the HE staining to observe the pathological changes of infected mice and rats. In addition, we measured mRNA levels of some cytokines (IL-5, IL-6, IL-13, Eotaxin, IL-4, IL-10, TGF-β, IFN-γ, IL-17A, TNF-α, IL-1β, and iNOS) in brain tissues of mice and rats by real-time PCR. The result showed that brain inflammation in mice was more serious than in rats. Meanwhile, mRNA expression levels of IL-6, IL-1β, TNF-α, and iNOS increased after mice were infected. In contrast, mRNA levels of these cytokines in rats brain tissues decreased at post- infection 21 days. These cytokines mostly were secreted by activated microglia in central nervous system. Microglia of mice and rats were showed by Iba-1 (microglia marker) staining. In micee brains, microglia got together and had more significant activation than in rats brains. The results demonstrate that mice and rats have different CNS inflammation after infection by A. cantonensis, and it is in line with other researchers' reported findings. In conclusion, it is suggested that microglia activation is probably to be one of the most important factors in angiostrongyliasis from our study.

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“…Dexamethasone prevents an inflammatory reaction by decreasing the production of eosinophils and the Th2-type immune response (Narala et al, 2007). To enhance effectiveness and avoid the side-effects of dexamethasone and rebound of the immune response after its withdrawal, several kinds of traditional Chinese medicine (TCM) have been used in combination with albendazole to replace dexamethasone He et al, 2011). To enhance effectiveness and avoid the side-effects of dexamethasone and rebound of the immune response after its withdrawal, several kinds of traditional Chinese medicine (TCM) have been used in combination with albendazole to replace dexamethasone He et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected withAngiostrongylus cantonensis

Tang

Chen

et al. 2011

J. Helminthol.

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Angiostrongylus cantonensis (A. cantonensis) infection causes eosinophilic meningitis in humans. Eosinophilia and a Th2-type immune response are the crucial immune mechanisms for eosinophilic meningitis. CD4+CD25+ regulatory T cells (Treg) are involved in the pathogenesis of A. cantonensis. Diammonium glycyrrhizinate (DG) is a compound related to glycyrrhizin (GL), a triterpene glycoside extracted from liquorice root. We investigated the curative effects and probable mechanisms of therapy involving a combination of albendazole and DG in BALB/c mice infected with A. cantonensis, and compared these with therapy involving albendazole and dexamethasone. We analysed survival time, body weight, signs, eosinophil numbers, immunoglobulin E (IgE), interleukin-5 (IL-5), and eotaxin concentrations, numbers and Foxp3 expression of CD4+CD25+ Treg, worm recovery and histopathology. The present results demonstrated that the combination of albendazole and DG could increase survival time more efficiently and relieve neurological dysfunction; decrease weight loss, eosinophil numbers, concentrations of IgE, IL-5 and eotaxin, the number and expression of Foxp3 of CD4+CD25+ Treg; and improve worm recovery and histopathology changes in treated animals, compared with the combination of albendazole and dexamethasone. The observations presented here suggest that the albendazole and dexamethasone combination could be replaced by the combination of albendazole and DG.

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Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice

Cited by 16 publications

References 34 publications

Human Angiostrongylus cantonensis: an update

Human Angiostrongylus cantonensis: an update

Microglia activation: one of the checkpoints in the CNS inflammation caused by Angiostrongylus cantonensis infection in rodent model

The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected withAngiostrongylus cantonensis

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