Efficacy of Combination Therapy With Fractional Carbon Dioxide Laser and Ultraviolet B Phototherapy for Vitiligo: A Systematic Review and Meta-Analysis

Chang, Heng-Chia; Lin, Ming Hsiu; Tsai, Hsiou Hsin

doi:10.1093/asj/sjz250

Cited by 6 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results demonstrated repigmentation response of 48.6% in the combination therapy group compared with 33.26% in the nb-UVB monotherapy group at day 168 (109). In a meta-analysis, Chang et al (110) evaluated the efficacy of combining nb-UVB with fractional CO 2 laser, but no additional benefit in repigmentation was observed. The adverse reactions of nb-UVB include burning, erythema, pruritus, xerosis, photoaging and photodamage (47).…”

Section: Phototherapymentioning

confidence: 99%

Updates and new medical treatments for vitiligo (Review)

et al. 2021

View full text Add to dashboard Cite

Vitiligo is a multifactorial disease characterized by the loss of skin pigment, which results in achromic macules and patches. There are currently several medical treatments available, which aim to arrest progression and induce skin repigmentation. These treatments alone or combined have exhibited varying degrees of pigmentation, and the majority are safe and effective. All therapies for vitiligo are limited, and no known treatment can consistently produce repigmentation in all patients. Individualized treatment is appropriate according to the location, clinical presentation and the presence of disease activity. The present review summarizes the medical treatments available for vitiligo: Systemic and topic pharmacological therapies, physical and depigmentation treatments. Several treatments are still underway and have not yet been approved. However, due to the promising preliminary results, these are also mentioned in the present review. Contents 1. Introduction 2. Pharmacological treatment 3. Physical therapy 4. Depigmentation therapies 5. Conclusions

show abstract

Section: Phototherapymentioning

confidence: 99%

Updates and new medical treatments for vitiligo (Review)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Similar conclusions were found by other reviews with varying inclusion criteria and outcome measures. [44][45][46][47] Finally, several surgical treatments may significantly improve repigmentation but tend to have more common and severe side effects, including cobblestoning with punch grafting and hyperpigmentation or infection with suction blister and cellular grafting techniques. Suction blister epidermal grafting may be more effective than PG, as demonstrated in a small metaanalysis (see Supplemental Digital Content, Figure S4, http://links.lww.com/DSS/B91).…”

Section: Discussionmentioning

confidence: 99%

Utilization of Our Toolkit: A Systematic Review and Meta-analysis of Surgical Therapies in Vitiligo Treatment

McCrary

Gibbs

Alharthi

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In 2020, two systematic reviews with meta‐analyses were published evaluating the safety and efficacy of fractional CO2 laser as an add‐on therapy for NB‐UVB 56,57 . Firstly, Kim et al .…”

Section: Fractional Laser For Enhancing Uv‐induced Repigmentationmentioning

confidence: 99%

“…55 In 2020, two systematic reviews with meta-analyses were published evaluating the safety and efficacy of fractional CO2 laser as an add-on therapy for NB-UVB. 56,57 Firstly, Kim et al conducted a meta-analysis with 3 RCTs, comparing NB-UVB monotherapy and CO2 laser combined with NB-UVB therapy, excluding any other treatment methods. [58][59][60] They demonstrated a higher repigmentation rate from combination therapy compared to NB-UVB alone.…”

Section: Fractional Laser For Enhancing Uv-induced Repigmentationmentioning

confidence: 99%

The use of lasers in vitiligo, an overview

Post

Ezekwe

Narayan

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

Various types of lasers have been demonstrated to be effective in the treatment of vitiligo. The mode of action of these lasers is just as varied as the purpose of intervention. Many clinicians are not aware of the unique opportunity these lasers offer to improve the outcomes of vitiligo treatment. To date, no clear overview exists of the use of lasers in vitiligo treatment. Thus, the aim of this review is to discuss the various types of lasers and provide an overview of the evidence for their efficacy. We found good evidence from a systematic review that the excimer laser is effective, induces repigmentation rates comparable to NB‐UVB and has improved outcomes when combined with calcineurin inhibitors. Ablative lasers are commonly used for tissue graft or melanocyte–keratinocyte cell graft transplantation. They provide safe, fast and uniform denudation of the epidermis with propitious repigmentation outcomes. We found conflicting evidence from two systematic reviews regarding the efficacy of fractional ablative lasers for improving outcomes of NB‐UVB therapy, a systematic review including only fractional ablative lasers provided evidence for efficacy. Q‐switched nanosecond lasers have shown to be safe and effective for inducing depigmentation, although recurrence is common, and most studies were small and retrospective. Despite proven efficacy and safety, laser treatments are relatively expensive and suited for limited body surface areas and selected cases. Each type of laser has benefits and risks associated and should, therefore, be individually chosen based on location, extent, activity and type of vitiligo.

show abstract

Efficacy of Combination Therapy With Fractional Carbon Dioxide Laser and Ultraviolet B Phototherapy for Vitiligo: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 9 publications

Updates and new medical treatments for vitiligo (Review)

Updates and new medical treatments for vitiligo (Review)

Utilization of Our Toolkit: A Systematic Review and Meta-analysis of Surgical Therapies in Vitiligo Treatment

The use of lasers in vitiligo, an overview

Contact Info

Product

Resources

About