Efficacy of CO₂ laser for treatment of anthroponotic cutaneous leishmaniasis, compared with combination of cryotherapy and intralesional meglumine antimoniate

Abstract

The CO(2) laser was more effective in treating dry-type cutaneous leishmaniasis than combined cryotherapy and intralesional glucantime and resulted in a shorter healing time (6 weeks vs. 12 weeks) with a single treatment session.

A randomized controlled phase IIb wound healing trial of cutaneous leishmaniasis ulcers with 0.045% pharmaceutical chlorite (DAC N-055) with and without bipolar high frequency electro-cauterization versus intralesional antimony in Afghanistan

“…So far, six physical treatment regimens have been proposed and clinically tested to disinhibit the healing delay of chronic wounds. In CL ulcers, thermotherapy (TT) [ 13 ],[ 31 ],[ 32 ] sparing host tissue, photodynamic therapy (PDT) [ 33 ]-[ 35 ] producing tissue 1 O 2 [ 36 ], cryotherapy (N 2 ) [ 37 ]-[ 39 ], CO 2 laser [ 40 ]-[ 43 ], and HF-EC [ 12 ] all elicited short-term constructive inflammatory reactions with beneficial ROS production in the tissue [ 44 ] and destroyed parasites and commensal bacteria together with host cells. Similarly, CAP presumably also acted by forming ROS in non-CL skin lesions [ 45 ],[ 46 ].…”

Rapid Healing of Cutaneous Leishmaniasis by High-Frequency Electrocauterization and Hydrogel Wound Care with or without DAC N-055: A Randomized Controlled Phase IIa Trial in Kabul

“…In Iran, the CO 2 laser was more effective than systemic meglumine antimonate [75] or cryotherapy combined with intralesional meglumine antimonate in patients with CL [76]. However, for Afghanistan, one of the lowest developed countries in the world with an unstable electrical power supply even in the big cities and no infrastructure for technical maintenance, a CO 2 laser is not the instrument of first choice for the treatment of CL lesions.…”

Effectiveness of meglumine antimoniate against L. tropica in a recently emerged focus of cutaneous leishmaniasis in Birjand, eastern Islamic Republic of Iran

“…Among 141 patients with L. tropica, 51 were injected intramuscular with Glucantime®, while 90 patients were treated intralesionally. Intralesional Glucantime® (Aventis; containing 81 mg antimony/mL) was injected intradermally (0.5-1 mL per lesion per week, depending on the size) in each lesion from all directions until the lesion was completely blanched (16). This treatment was carried out once per week until there was complete healing of the ulcer or for a maximum of 12 weeks.…”