Efficacy of clinical prognostic factors on survival in patients with glioblastoma

Tuğcu, Betül; Postalcı, Lütfi Şinasi; Günaldı, Ömür; Tanrıverdi, Osman; Akdemir, Hidayet

doi:10.5137/1019-5149.jtn.2461-09.4

Cited by 19 publications

(30 citation statements)

References 30 publications

(54 reference statements)

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“…Despite recent advances in surgery, radiotherapy and chemotherapy, this strategy yields a median survival of 14.6 months, with a 2-and 5-year survival rate of 27.2% and 9.8%, respectively [1]. Recurrence is the main reason for poor prognosis [2]. Cancer stem cells (CSCs) are known to be chemoradiotherapy resistant.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Intranasal GM-CSF enhances efficacy of local ACNU delivery rendezvousing with TMZ plus irradiation in glioblastoma

Yang¹,

Bu²,

Xue³

et al. 2018

Oncotarget

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This study aims to investigate the efficacy and safety of intranasal granulocytemacrophage colony stimulating factor (GM-CSF) treatment rendezvousing with chemoradiotherapy for post-operative glioblastoma patients. A total of ninety-two patients were randomized into two groups: control group (n = 46), patients who received radiotherapy with concomitant and adjuvant local delivery of nimustine hydrochloride (ACNU) rendezvousing with systemic administration of temozolomide (TMZ); observation group (n = 46), patients who received intranasal GM-CSF prior to each cycle of adjuvant chemotherapy based on the control group. Karnofsky performance status (KPS) scores, progression-free survival (PFS), overall survival (OS) and adverse effects were compared between these two groups. Two patients in the control group were excluded due to grade 3 hematologic toxicity. Furthermore, the observation group was superior to the control group with regard to PFS (7.8 months vs. 6.9 months, P = 0.016) and OS (19.2 months vs. 17.1 months, P = 0.045 without adjustment for interim analyses). KPS scores was higher in the observation group than in the control group after six months (84.35 ± 8.86, 80.65 ± 7.72; t = 4.552, P = 0.036). Neutropenia and thrombocytopenia decreased in the observation group, with incidences of 8.7% and 8.7%, respectively, when compared with the control group (29.5% and 18.2%, respectively; P = 0.012); while other adverse events were similar in both groups. Most adverse events were grade I-II and resolved spontaneously. Intranasal GM-CSF enhances the efficacy of the local delivery of ACNU rendezvousing with oral TMZ chemotherapy associated with significantly improved survival and quality of life in glioblastoma patients after surgery. This therapy could relieve chemotherapy related neutropenia, and does not increase the adverse events of other aspects.www.impactjournals.com/oncotarget/

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Intranasal GM-CSF enhances efficacy of local ACNU delivery rendezvousing with TMZ plus irradiation in glioblastoma

Yang¹,

Bu²,

Xue³

et al. 2018

Oncotarget

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“…Several studies have reported that tumour regions influence OS; 35,36 other multivariate analyses found that the location of the tumour might have a better prognosis, but its effect size is not enough to define this feature as an independent factor. 2,37 In our analysis, we did not find a significant association between tumour region and survival.…”

mentioning

confidence: 53%

“…2 The presence of AA and GBM explains the median survival time of 1.73 years. Although some researchers reported a 3-year life period for patients with glioblastoma of 3% and a 5-year lifetime of 0%, there are citations of patients surviving GBM up to 10 years.…”

Section: Discussionmentioning

confidence: 99%

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Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas

Roldan-Valadez¹,

Rı́os

Motola-Kuba³

et al. 2016

BJR

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S. Choline-to-N-acetyl aspartate and lipids-lactate-tocreatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas. Br J Radiol 2016; 89: 20150502. FULL PAPERCholine-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas Objective: A long-lasting concern has prevailed for the identification of predictive biomarkers for high-grade gliomas (HGGs) using MRI. However, a consensus of which imaging parameters assemble a significant survival model is still missing in the literature; we investigated the significant positive or negative contribution of several MR biomarkers in this tumour prognosis. Methods: A retrospective cohort of supratentorial HGGs [11 glioblastoma multiforme (GBM) and 17 anaplastic astrocytomas] included 28 patients (9 females and 19 males, respectively, with a mean age of 50.4 years, standard deviation: 16.28 years; range: 13-85 years). Oedema and viable tumour measurements were acquired using regions of interest in T 1 weighted, T 2 weighted, fluid-attenuated inversion recovery, apparent diffusion coefficient (ADC) and MR spectroscopy (MRS). We calculated Kaplan-Meier curves and obtained Cox's proportional hazards.Results: During the follow-up period (3-98 months), 17 deaths were recorded. The median survival time was 1.73 years (range, 0.287-8.947 years). Only 3 out of 20 covariates (choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios and age) showed significance in explaining the variability in the survival hazards model; score test: x 2 (3) 5 9.098, p 5 0.028. Conclusion: MRS metabolites overcome volumetric parameters of peritumoral oedema and viable tumour, as well as tumour region ADC measurements. Specific MRS ratios (Cho/Naa, L-L/Cr) might be considered in a regular follow-up for these tumours. Advances in knowledge: Cho/Naa ratio is the strongest survival predictor with a log-hazard function of 2.672 in GBM. Low levels of lipids-lactate/Cr ratio represent up to a 41.6% reduction in the risk of death in GBM.

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“…Yetişkin erkeklerde kadınlara oranla daha sık görülmekle beraber, 15 yaşın altındaki çocuk tü-mörlerinin %50'sini oluşturmaktadır. [1][2][3][4][5] Yüksek derece beyin tümörleri olarak sınıf-landırılan IV. derece gliomalar ya da GBM'nin sağkalım oranı düşük, prognozu da kötüdür.…”

Section: Glioblastoma Multiform Tedavisinde üç Boyutlu Konformal Radyunclassified

Comparison of Three Dimensional Conformal Radiotherapy and Intensity Modulated Radiotherapy Techniques for the Treatment of Glioblastoma Multiform

Dağli¹,

Haydaroğlu²,

Olacak³

et al. 2013

Turkiye Klinikleri J Med Sci

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Efficacy of clinical prognostic factors on survival in patients with glioblastoma

Abstract: We could show that some clinical parameters and treatment modalities were associated with prognosis. Younger age, male gender, higher Karnofsky Performance Score at discharge, total surgical resection, radiotherapy and reoperation were predictor for better prognosis.

Cited by 19 publications

References 30 publications

WITHDRAWN: Intranasal GM-CSF enhances efficacy of local ACNU delivery rendezvousing with TMZ plus irradiation in glioblastoma

WITHDRAWN: Intranasal GM-CSF enhances efficacy of local ACNU delivery rendezvousing with TMZ plus irradiation in glioblastoma

Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas

Comparison of Three Dimensional Conformal Radiotherapy and Intensity Modulated Radiotherapy Techniques for the Treatment of Glioblastoma Multiform

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