Efficacy of chemical disinfectants against SARS-CoV-2 on high-touch surface materials

Abstract

Aims This study aimed to provide operationally relevant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface disinfection efficacy information. Methods and Results Three EPA-registered disinfectants (Vital Oxide, Peroxide, and Clorox Total 360) and one antimicrobial formulation (CDC bleach) were evaluated against SARS-CoV-2 on material coupons and were tested using Spray (no touch with contact time) and Spray & Wipe (wipe immediately post-application) methods immediately and 2 h post-contamination. Efficacy was evaluated for infectious virus, with a subset tested for viral RNA (vRNA) recovery. Efficacy varied by method, disinfectant, and material. CDC bleach solution showed low efficacy against SARS-CoV-2 (log reduction < 1.7), unless applied via Spray & Wipe. Additionally, mechanical wiping increased the efficacy of treatments against SARS-CoV-2. The recovery of vRNA post-disinfection suggested that vRNA may overestimate infectious virus remaining. Conclusions Efficacy depends on surface material, chemical, and disinfection procedure, and suggests that mechanical wiping alone has some efficacy at removing SARS-CoV-2 from surfaces. We observed that disinfectant treatment biased the recovery of vRNA over infectious virus. Significance and Impact of Study These data are useful for developing effective, real-world disinfection procedures, and inform public health experts on the utility of PCR-based surveillance approaches.

Contact dermatitis caused by prevention measures during the COVID-19 pandemic: a narrative review

“…In some countries, coastal areas and densely populated cities have a higher risk of virus transmission ( 97 ). Recognizing the potential risk of airborne transmission of SARS-CoV-2, the use of environmental disinfection can help reduce any residual virus on indoor surfaces and in the air, especially in hospitals, classrooms, shopping malls and other places where crowds gather ( 98 , 99 ). Sodium hypochlorite, ethanol, isopropanol and glutaraldehyde are examples of environmental disinfectants in common use ( 100 ).…”