Potato is an important food crop in the world as well as in India. It is being affected by different pathogens, viz. fungi, bacteria, viruses and nematodes. These pathogens may cause significant yield losses of the crop, if proper protection measures have not been applied. Among potato pathogens, Phytophthora infestans, Alternaria solani, Rhizoctonia solani and Fusarium spp. are the major pathogens in the fungal group, whereas Ralstonia solanacearum, Pectobacterium spp. and Streptomyces spp. are in the bacterial group. For management of these pathogens, various methods, that is, chemical control, biological control, resistant varieties, cultural control and physical control, are applied. Resistant varieties are the best and cheapest method for managing the diseases. However resistant varieties are break down their resistant over the years and moreover against some pathogen absolute resistant are not available. Chemical management is the second best option for managing the diseases, due to continuous and irrational use of the chemicals; pathogens have developed resistance against certain class of fungicides/bactericides. Moreover, these chemicals also assist in environmental pollution and toxicity in the produce. Bio-agents are naturally occurring living organisms, which are found in rhizosphere, phylloplane, etc. These bio-agents help in not only managing the diseases but also increasing the crop yield. Therefore, the use of bio-agents for biological management of potato crops is the focused research area worldwide.