Efficacy of calcitriol in treating glucocorticoidinduced osteoporosis in patients with nephrotic syndrome: an open-label, randomized controlled study

Chen, Yi; Wan, Jianxin; De-wen, Jiang; Fu, Bin-Bin; Cui, Jiong; Li, Guifen; Chen, Cai-Ming

doi:10.5414/cn108473

Cited by 7 publications

(4 citation statements)

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“…Die SLR erfolgte in Anlehnung an die 2017 aktualisierte Leitlinie des American College of Rheumatology (ACR) [19,20] 1 Bezüglich der Effekte einer Kalziumbzw. Vitamin-D-Monotherapie und der Kombination von Kalzium und Vitamin D3 ergab eine dreiarmige "openlabel" randomisiert kontrollierte Studie mit 66 GC-behandelten Patienten, dass die Behandlung mit Vitamin D (als Monotherapie) und Vitamin D plus Kalzium (0,81 g/cm 2 und 0,82 g/cm 2 ) mit signifikant höheren Knochenmineraldichtewerten an der LWS im Vergleich zur Kalziummonotherapie nach 24 Wochen assoziiert war (0,62 g/cm 2 , p < 0,05 jeweils) [23]. Auch in dieser Studie war die BMD in allen 3 Armen rückläufig.…”

Section: Systematische Literaturrechercheunclassified

Empfehlungen der Deutschen Gesellschaft für Rheumatologie zum Management der Glukokortikoid-induzierten Osteoporose

Leipe

Holle²,

Weseloh³

et al. 2021

Z Rheumatol

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Jan Leipe 1,2 für die Kommission Pharmakotherapie der Deutschen Gesellschaft für Rheumatologie e. V. (DGRh) • Julia U. Holle 3 für die Kommission Pharmakotherapie der Deutschen Gesellschaft für Rheumatologie e. V. (DGRh) • Christiane Weseloh 4 für die Kommission Pharmakotherapie der Deutschen Gesellschaft für Rheumatologie e. V. (DGRh) • Alexander Pfeil 5 • Klaus Krüger 6 für die Kommission Pharmakotherapie der Deutschen Gesellschaft für Rheumatologie e. V. (DGRh)

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Section: Systematische Literaturrechercheunclassified

Empfehlungen der Deutschen Gesellschaft für Rheumatologie zum Management der Glukokortikoid-induzierten Osteoporose

Leipe

Holle²,

Weseloh³

et al. 2021

Z Rheumatol

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“…In addition, calcitriol directly affects the skeletal, intestinal, renal, and parathyroid systems. It enhances the sensitivity of the parathyroid glands to calcium and inhibits transcriptional activity of PTH gene and proliferation efficiency of parathyroid cells, thereby reducing secretion and synthesis of PTH [18,19]. However, it is essential to closely monitor patients' blood Ca and Pi concentrations when using calcitriol.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of calcitriol in the treatment of patients with renal osteodystrophy

Jiang,

Tang,

Zhang

et al. 2024

Trop. J. Pharm Res

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Purpose: To investigate the efficacy and prognosis of calcitriol in patients with renal osteodystrophy (ROD). Methods: 60 patients with ROD admitted to The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, China between June 2020 and June 2021 were randomly grouped into control (n = 30) and study groups (n = 30). Patients in control group received routine management study group was treated with routine management plus calcitriol. The treatment duration was six months. Serological markers (parathyroid hormone (PTH), calcium (Ca), and phosphorus (Pi)), renal function indices (blood creatinine (SCr), urea nitrogen (BUN), and alkaline phosphatase (ALP)), as well as patients’ skeletal conditions of the spine, pelvis, and extremities were investigated. Additionally, postoperative complications and clinical efficacy were also evaluated. Results: Study group showed significant improvement in serological markers compared to control group (p < 0.05). Also, study group had significantly reduced SCr, BUN, and ALP levels (p < 0.05) compared to control group. There was significantly reduced incidence of complications and better skeletal conditions in study group compared to control group (p < 0.05). Conclusion: Calcitriol effectively mitigates blood-bone mechanism dysfunction and reduces the occurrence of complications in patients with ROD. However, factors such as Scr, Hb, and blood pressure affect the clinical efficacy of calcitriol on renal bone disease by mechanisms that will be investigated in the future.

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“…Normalization and detoxification for vitamin D3 derivatives is 2-4 weeks and 7 to 30 days, and 4 to 7 days and 2 to 10 days for calcitriol. 18 For restoring the vitamin D resources in the body, the time required is 2-3-fold higher for vitamin D3 preparations compared to vitamin D2 derivatives. 15 Interventional strategies are required to prevent bone diseases in patients with nephrotic syndrome, and the efficacies of different preparations have been compared in some studies.…”

Section: Discussionmentioning

confidence: 99%

“…15 Interventional strategies are required to prevent bone diseases in patients with nephrotic syndrome, and the efficacies of different preparations have been compared in some studies. Chen et al 18 reported the preferred form of vitamin D as calcitriol alone in comparison to calcium carbonate alone or their combination. They found no adverse effects in their study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy

Mahmoodzadeh

Valizadeh

Nikibakhsh

et al. 2020

Int J Basic Sci Med

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Introduction: Nephrotic syndrome is one of the most common glomerular diseases in children who are also at risk of metabolic bone diseases. In this study the effect of supplementary use of vitamin D3 was assessed on serum levels of vitamin D3 in patients with nephrotic syndrome receiving steroid therapy. Methods: Thirty children with nephrotic syndrome were included in this study. After obtaining blood samples to measure 25(OH) D levels, all patients were supplemented with daily doses of Vitamin D for one month. Serum 25(OH) D level was checked again, and these patients were supplemented for another month if they had been recognized with deficiency at the last check. Results: Out of 30 children, 60% were male and 40% were female with a mean age of 6.91 ± 3.34 years. Before intervention, 70% of patients had severe vitamin D deficiency, and 26.7% had mild to moderate deficiency, and none of the patients had normal serum levels of 25-(OH)-D. After one month, only one patient gained normal levels which was not statistically significant (P=0.500). After two months of intervention, 12 patients escaped deficiency but still exhibited insufficient levels followed by 8 people with deficiency, and 10 patients reached normal values which was statistically significant (P=0.002). The mean level of 25(OH) D was 8.277±0.84 ng/ mL rising to 14.364±1.14 ng/mL after two months (P=0.001). Conclusion: This study showed a high incidence of vitamin D deficiency in the children with nephrotic syndrome warranting routine surveillance of vitamin D serum levels in these patients. Daily doses of vitamin D in the first month of onset of the disease was insufficient. We suggest that children may benefit from routine measurement of their serum vitamin D from diagnosis and later in follow-up visits so an individual strategy for vitamin D supplementation could be given.

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Efficacy of calcitriol in treating glucocorticoidinduced osteoporosis in patients with nephrotic syndrome: an open-label, randomized controlled study

Abstract: Calcitriol may be more effective than calcium carbonate in preventing and treating GC-induced osteoporosis in patients with NS.

Cited by 7 publications

References 0 publications

Empfehlungen der Deutschen Gesellschaft für Rheumatologie zum Management der Glukokortikoid-induzierten Osteoporose

Empfehlungen der Deutschen Gesellschaft für Rheumatologie zum Management der Glukokortikoid-induzierten Osteoporose

Efficacy of calcitriol in the treatment of patients with renal osteodystrophy

Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy

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