2022
DOI: 10.20945/2359-3997000000481
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Efficacy of cabergoline add-on therapy in patients with acromegaly resistance to somatostatin analogs treatment and the review of literature

Abstract: Objectives: It is reported that adding cabergoline to somatostatin analog (SSA) normalizes IGF-1 levels approximately in one-third of patients with acromegaly. We investigated the effect of combination therapy and potential predictors of response in patients with acromegaly who do not respond to SSA therapy alone. Subjects and methods: Fifty acromegaly patients (M/F 23/27, mean age 50.88 ± 12.34 years) were divided into two groups as the active and control groups in this connection. Before and after treatment,… Show more

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Cited by 4 publications
(2 citation statements)
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“…Immunohistochemical staining for other pituitary hormones is a useful practice for the evaluation of acromegaly patients as it can identify tumors with hormonal cosecretion, the most frequent one being GH–prolactin cosecretion. While the exact relationship between GH–prolactin cosecretion and other clinical and HP characteristics is not clear, several studies found that these types of tumors present a better response to DA in terms of IGF-1 decrease, thus prolactin staining could potentially have a role in choosing the optimal medical treatment for patients with active acromegaly [ 77 , 78 ] (Figure 1 ; Table 1 ).…”
Section: Cytoskeleton: Filamin a Beta-arrestinsmentioning
confidence: 99%
“…Immunohistochemical staining for other pituitary hormones is a useful practice for the evaluation of acromegaly patients as it can identify tumors with hormonal cosecretion, the most frequent one being GH–prolactin cosecretion. While the exact relationship between GH–prolactin cosecretion and other clinical and HP characteristics is not clear, several studies found that these types of tumors present a better response to DA in terms of IGF-1 decrease, thus prolactin staining could potentially have a role in choosing the optimal medical treatment for patients with active acromegaly [ 77 , 78 ] (Figure 1 ; Table 1 ).…”
Section: Cytoskeleton: Filamin a Beta-arrestinsmentioning
confidence: 99%
“…To sum up, the publication by Kizilgul and cols. (1) showing once more the efficacy of cabergoline in the treatment of acromegaly is a timely reminder that dopaminergic treatment still has an important role, at a relatively low cost, in the current management of acromegaly. It is noteworthy that cabergoline is included in the drugs' list for the treatment of acromegaly in our public health system.…”
mentioning
confidence: 99%