Efficacy of Buprenorphine Added 2 % Lignocaine 1:80000 in Postoperative Analgesia After Minor Oral Surgery

Influence of Lidocaine including Buprenorphine for Postoperative Analgesia after the Extraction of Mandibular Third Molars: A Randomized Controlled, Double-Blind, Split-Mouth Study

“…However, it was also found to be associated with postoperative nausea and vomiting [ 10 ]. Based on our literature search, only two studies have been published regarding the use of buprenorphine with LA for intraoral block-related surgical procedures [ 16 , 17 ]. However, other studies comparing the efficacy of tramadol hydrochloride as an anesthetic agent compared to lidocaine hydrochloride for the maxillary infiltration technique and orthodontic tooth extraction procedure have shown tramadol hydrochloride to be an effective alternative local anesthetic and with better postoperative analgesic property [ 29 , 30 ]…”

“…This finding was consistent with the findings in the other two studies. Chhabra et al, in their study, reported that patients remained pain-free for 12 hours on administering buprenorphine-mixed LA solution [ 16 ], while Kumar et al, in their study, reported a pain-free period of up to 36 hours after the procedure [ 17 ]. This prolonged duration of postoperative analgesia, denoted by the low VAS pain scores, can be attributed to the highly lipophilic nature and slow dissociation of buprenorphine from the opioid receptors.…”

Efficacy of lignocaine with buprenorphine versus lignocaine in the management of postoperative pain after minor oral surgical procedures: A systematic review and meta-analysis

“…Overall, two studies with 140 subjects were included for meta-analysis. Overall, the risk of bias was low for Chhabra et al [ 21 ] and while it is unclear for the study done by Kumar et al [ 22 ] Chhabra et al [ 21 ] evaluated the patients undergoing third molar extraction and evaluated intraoperative and postoperative parameters (onset of anesthesia, depth of anesthesia, duration of anesthesia, duration of PoA, the severity of PoP, and number of RA taken). Subjects were randomized into three groups such as Inferior alveolar nerve block (IANB) with 2% lignocaine and 1:80,000 adrenaline, IANB with 0.01mg buprenorphine/ml of 2% lignocaine with 1:80,000 adrenaline and IANB with 2% lignocaine and 1:80,000 adrenaline with 0.03mg IM buprenorphine.…”

“…Subjects were randomized into three groups such as Inferior alveolar nerve block (IANB) with 2% lignocaine and 1:80,000 adrenaline, IANB with 0.01mg buprenorphine/ml of 2% lignocaine with 1:80,000 adrenaline and IANB with 2% lignocaine and 1:80,000 adrenaline with 0.03mg IM buprenorphine. Kumar et al [ 22 ] evaluated the patients undergoing various types of intra-oral minor surgical procedures such as third molar surgeries, alveoloplasties, and cyst enucleation. They did not specify the type of nerve block/infiltration administered.…”

“…However, the exact assessment time interval was not explicitly mentioned. Kumar et al [ 22 ] systematically evaluated PoP assessment at 2, 4, 6, 12, 24, 36, 48, and 72h. Also, patients daily rating of discomfort was recorded.…”