Efficacy of Brazilian propolis extract and gel for the management of denture stomatitis

Santos, VR; Gomes, RT; Teixeira, Kir; Pretti, Henrique; Aguiar, EG; Cortes, M. V. C. B.

doi:10.1055/s-0029-1234297

Cited by 1 publication

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“…The involvement of Candida biofilm-formation on denture materials leads to considerable efforts devoted to the development of antifungal denture materials for the management of CADS [17–31]. The current study used PNVP-grafted acrylic denture resins for rechargeable antifungal drug delivery.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

Sun

Cao²,

Yeh

et al. 2013

Colloids and Surfaces B: Biointerfaces

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Colonization and biofilm-formation of Candida species on denture surfaces cause Candida-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67% of denture wearers. We developed poly(N-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to achieve long-term antifungal and biofilm-controlling effects. The monomer, N-vinyl-2-pyrrolidinone (NVP), was grafted onto poly(methyl methacrylate) denture resins through plasma-initiated grafting polymerization. The physical properties and biocompatibility of the resulting resins were not negatively affected by the presence of up to 7.92% of grafted poly (N-vinyl-2-pyrrolidinone) (PNVP). Miconazole and chlorhexidine digluconate (CD) were used as model antifungal drugs. PNVP grafting significantly increased the drug absorption capability of the resulting denture materials. Further, the new materials showed sustained drug release and provided antifungal effects for weeks (in the case of CD) to months (in the case of miconazole). The drug-depleted resins could be recharged with the same or a different class of antifungal drug to further extend antifungal duration. If needed, drugs on the PNVP-grafted denture materials could be “washed out” (quenched) by treating with PNVP aqueous solutions to stop drug release. These results point to great potentials of the new materials in controlling biofilm-formation in a wide range of device-related applications.

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Section: Discussionmentioning

confidence: 99%