Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies

Shimizu, Tomomi; Takeshita, Youhei; Takamori, Yasushi; Hao, Kai; Sawamura, Rie; Yoshida, Hiroki; Watanabe, Wataru; Tsutsumi, Akihisa; Park, Yong Kun; Yasukawa, Ken; Matsuno, Koji; Shiraki, Kimíyasu; Kurokawa, Mineo

doi:10.1155/2011/976196

Cited by 54 publications

(65 citation statements)

References 28 publications

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“…The anti‐HSV effect of propolis was tested in an in‐vitro and in‐vivo study and propolis was found to have an inhibitory effect on viral infection probably owing to the prevention of virus absorption into the host cells and/or inhibition of an internal step(s) during the viral replication cycle, thus preventing the appearance and development of symptoms in vivo . In another study, Brazilian propolis showed not only direct anti‐HSV‐1 activity but also immunological activity against intradermal HSV‐1 infection in mice …”

Section: Discussionmentioning

confidence: 96%

“…In another study, Brazilian propolis showed not only direct anti-HSV-1 activity but also immunological activity against intradermal HSV-1 infection in mice. 72 Repair of oral wounds Propolis in aqueous alcohol solution exerted a small analgesic and anti-inflammatory effect and also aided repair of intra-buccal surgical wounds after sulculoplasty by modified Kazanjian technique. 73 Topical application of propolis hydro-alcoholic solution was found to accelerate epithelial repair after tooth extraction but had no effect on socket wound healing.…”

Section: Antiviralmentioning

confidence: 99%

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Role of propolis in dentistry: review of the literature

Sardana¹,

Indushekar²,

Manchanda³

et al. 2013

Focus on Alt & Comp Therapy

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Background Propolis (also called bee glue) is a resinous substance derived from bees. It has long been used in medicine for its beneficial properties, including antimicrobial, anti‐inflammatory, antidiabetic and local anaesthetic effects. In dentistry, propolis has been used for the prevention of dental caries and periodontal diseases, as an interim transport medium for avulsed teeth, and in endodontics, orthodontics and periodontics. Objective To highlight the role of propolis in dentistry. Methods A PubMed search was made using the keywords propolis, beeglue, antimicrobial, dental and herbs without any limits on the date of publication. No specific inclusion or exclusion criteria were applied as the purpose of the review was to make it as comprehensive as possible. Discussion The role of propolis is discussed in various branches of dentistry, including: preventive dentistry, dental traumatology, endodontics, periodontology, orthodontics and oral oncology. Conclusion Although most research published in the dental literature on propolis is based on in‐vitro studies or animal studies, extrapolating the results of these present studies to clinical practice may be too early as these results may not be necessarily replicated in human trials. In future, propolis may find a definitive role in one or more applications in dentistry; however, clinical trials are necessary to isolate the individual components responsible for its beneficial effects and to study them.

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Section: Discussionmentioning

confidence: 96%

Section: Antiviralmentioning

confidence: 99%

Role of propolis in dentistry: review of the literature

Sardana¹,

Indushekar²,

Manchanda³

et al. 2013

Focus on Alt & Comp Therapy

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“…SHIMIZU, et al (2011), utilizando um modelo animal concluíram que a própolis não apresenta somente uma atividade direta contra o HSV-1, mas também uma atividade imunológica contra a infeção intradérmica causada por este vírus em ratos. Os resultados de Yildirim, et al (2016) utilizando própolis demonstraram que ela apresenta importantes efeitos antivirais comparados ao Aciclovir.…”

Section: Discussionunclassified

Avaliação Do Efeito De Pomada De Própolis Para Tratamento De Herpes Labial Recorrente – Um Estudo Piloto

Variani

Palludo²,

Pensin³

et al. 2017

Arq. Ciênc. Saúde Unipar

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RESUMO:O herpes labial recorrente é uma infecção viral cuja prevalência em adultos e adolescentes varia de 10 a 15%. As lesões herpéticas aparecem em quadros recorrentes e atingem a região peribucal na forma de lesões vésico-bolhosas autolimitantes. O tratamento é realizado comumente pelos medicamentos antivirais como é o caso do Aciclovir, no entanto há apenas o controle e não a cura da doença. As terapias naturais são cada vez mais procuradas pelas pessoas, dentre as quais destaca-se a utilização da própolis. A própolis é um composto resinoso produzido pelas abelhas para proteção da colmeia. Inúmeros trabalhos demonstram propriedades farmacológicas da própolis, como por exemplo, bactericida e anti-inflamatória. Pesquisas na área odontológica demonstram a utilização da própolis para diversas enfermidades bucais, incluindo o herpes labial recorrente. O objetivo deste trabalho foi analisar o efeito da própolis na forma de pomada para o tratamento de lesões herpéticas. Os resultados obtidos demonstraram que o uso da pomada de própolis a 5% reduziu o tempo de cicatrização, bem como aumentou o intervalo entre as recidivas de lesões herpéticas. Tais resultados são promissores, entretanto, considerando ser um estudo preliminar, novos trabalhos nesta área devem ser realizados para solidificar a eficácia da própolis em pomada para tratamento de herpes labial recorrente. PALAVRAS-CHAVE: Herpes simples. Própolis. Tratamento. "USE OF PROPOLIS OINTMENT FOR RECURRENT ORAL HERPES TREATMENT -A PILOT STUDY"ABSTRACT: Recurrent oral herpes is a viral infection with 10 to 15% prevalence in adults and adolescents. The herpetic lesions appear in recurring episodes and affect the perioral region in the form of vesicobullous self-limiting injuries. It is most commonly treated by using antivirals such as acyclovir, but these are only for control rather than cure. Natural therapies are increasingly sought after, among which the use of propolis. Propolis is a resinous compound produced by bees for the protection of the hive. Several studies have shown the pharmacological properties of propolis, for example, as a bactericide and anti-inflammatory use. Research in the dental field has demonstrated the use of propolis for various oral diseases, including recurrent oral herpes. The aim of this study was to analyze the effect of propolis as an ointment for the treatment of herpetic lesions. The results showed that the use of 5% propolis ointment reduced healing time and caused an extension between relapses in patients with lesions. Despite being from a preliminary study, these results are considered promising, and further studies in the area should be held in order to solidify the effectiveness of propolis ointment for treating recurrent oral herpes. KEY WORDS: Herpes simplex. Propolis. Treatment. IntroduçãoO herpes labial recorrente (HLR) ou herpes simples é uma doença infecciosa aguda e, provavelmente, a virose mais prevalente em humanos. Os tipos mais comuns de vírus causadores do HLR são o Herpes Simples Vírus (HSV) tipos 1 e 2. O HSV é o...

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“…A number of studies conducted in several different laboratories also indicated that propolis, as well as some of its components, was active in increasing the secretion of several cytokines and the mechanisms involved are not clear yet. (9)(10)(11)(12)(13)(14) It should be pointed out that overproduction of some cytokines is not beneficial and frequently associated with inflammatory response or autoimmunity, as raised kindly by Dr. Salvatore Chirumbolo.…”

Section: Dear Editor-in-chiefmentioning

confidence: 99%