Efficacy of blood parameters in predicting the severity of gestational hypertension and preeclampsia

Ozkan, Dogukan; İbanoğlu, Müjde Can; Adar, Kevser; Özkan, Merve; Tapisiz, Omer Lutfi; Engin-Üstün, Yaprak; İskender, Cantekin

doi:10.1080/01443615.2022.2144175

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…The study involved 320 pregnant patients, and the results indicated that an NLR value greater than 3.7 could potentially be a sign of organ dysfunction in pre-eclamptic patients [30]. In recent years, a large number of further studies have been published on the association between elevated NLR values and pregnancy-related conditions such as gestational diabetes mellitus and pregnancy-induced hypertension [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Predicting Potentially Fatal COVID-19 Disease in Pregnant Patients Using the Neutrophil-to-Lymphocyte Ratio (NLR)

Supák,

Mészáros,

Turi

et al. 2023

JCM

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Objective: To evaluate the neutrophil-to-lymphocyte ratio (NLR) values’ possible predictive role in fatal and severe cases of COVID-19 disease in pregnant women. Design and data collection: A case-control study was conducted with the inclusion of 45 pregnant COVID-19 patients. All the data were obtained from the hospital information system of Semmelweis University by two of the authors. Results: Statistical analyses showed that NLR values were significantly higher in patients with fatal COVID-19 compared to those who survived the disease, with or without mechanical ventilation. The study also assessed whether NLR values measured on the first day of hospitalization or at their peak provided better markers of disease severity. While both the first-day and peak NLR values were evaluated in patients who did not survive the disease, only the peak NLR values had predictive value regarding patient death. Conclusion: Based on our results, the peak NLR values appear to be useful markers of COVID-19 severity, with a cut-off value of 18.05. However, the authors suggest and hope that larger sample size studies will be conducted to further validate the findings of their research.

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Section: Discussionmentioning

confidence: 99%

Predicting Potentially Fatal COVID-19 Disease in Pregnant Patients Using the Neutrophil-to-Lymphocyte Ratio (NLR)

Supák,

Mészáros,

Turi

et al. 2023

JCM

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“…16 Ozkan et al reported that NLR, PLR, the delta neutrophil index (DNI) and platelet distribution width (PDW) have no clinical importance in predicting the severity of preeclampsia and assessing the risk of developing gestational hypertension and preeclampsia. 17 Kang et al sugested that NLR is higher in preeclampsia, especially in its severe forms. NLR might be an effective laboratory marker for clinical prediction and disease severity evaluation in preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Are NLR, PLR, and Elevated Uric Acid Levels Predictive of Preeclampsia?

Corduneanu,

Căpîlna

2023

Journal of Cardiovascular Emergencies

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Background It is estimated that 2 to 8% of pregnancies are complicated by gestational hypertension and preeclampsia, the latter being considered a major cardiovascular emergency due to its possible progression to severe eclampsia and HELLP syndrome. New inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), may predict the progression of gestational hypertension. Aim of the study The aim of this study was to assess whether NLR, PLR, and uric acid play a role in predicting preeclampsia and its severe forms. Methods This prospective, single-center cohort study, conducted between January 1, 2020 and December 31, 2022, included 107 pregnant women with gestational hypertension, preeclampsia and its severe forms, HELLP syndrome and eclampsia. Patients were divided into two groups: the first group included 88 patients with gestational hypertension (GH group), and the second group included 19 patients with preeclampsia and its severe forms (PE group). We compared demographic, clinical and biochemistry data between the two groups. Results PLR was significantly lower in women with preeclampsia (85.47 ± 7.91 vs. 115.90 ± 4.63, p = 0.005). The mean serum uric acid level in the PE group was significantly higher than in the GH group (6.71 ± 0.44 mg/dL vs. 4.59 ± 0.12 mg/dL, p <0.0001). Conclusion In this study, low-cost biomarkers PLR and serum uric acid were associated with a higher risk of PE and its severe forms and may be used to predict the progression of gestational hypertension.

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“…It has been shown that BP values > 160–100 mmHg altered the cerebral autoregulation and cerebral edema, which begins to be a frequent finding [ 53 , 54 ]. Likewise, it has recently been shown that severe hypertension has the same maternal-fetal morbidity and mortality as PE [ 55 ]. Therefore, the therapeutic indication is indisputable in HDP when the BP office exceeds 160–100 mmHg.…”

Section: Hypertension Control In Pregnant Women With Chronic Hyperten...mentioning

confidence: 99%

Ambulatory Blood Pressure Monitoring for Diagnosis and Management of Hypertension in Pregnant Women

Espeche

Salazar

2023

Diagnostics

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Hypertension disorders during pregnancy has a wide range of severities, from a mild clinical condition to a life-threatening one. Currently, office BP is still the main method for the diagnosis of hypertension during pregnancy. Despite of the limitation these measurements, in clinical practice office BP of 140/90 mmHg cut point is used to simplify diagnosis and treatment decisions. The out-of-office BP evaluations are it comes to discarding white-coat hypertension with little utility in practice to rule out masked hypertension and nocturnal hypertension. In this revision, we analyzed the current evidence of the role of ABPM in diagnosing and managing pregnant women. ABPM has a defined role in the evaluation of BP levels in pregnant women, being appropriate performing an ABPM to classification of HDP before 20 weeks of gestation and second ABMP performed between 20–30 weeks of gestation to detected of women with a high risk of development of PE. Furthermore, we propose to, discarding white-coat hypertension and detecting masked chronic hypertension in pregnant women with office BP > 125/75 mmHg. Finally, in women who had PE, a third ABPM in the post-partum period could identify those with higher long-term cardiovascular risk related with masked hypertension.

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Efficacy of blood parameters in predicting the severity of gestational hypertension and preeclampsia

Cited by 6 publications

References 29 publications

Predicting Potentially Fatal COVID-19 Disease in Pregnant Patients Using the Neutrophil-to-Lymphocyte Ratio (NLR)

Predicting Potentially Fatal COVID-19 Disease in Pregnant Patients Using the Neutrophil-to-Lymphocyte Ratio (NLR)

Are NLR, PLR, and Elevated Uric Acid Levels Predictive of Preeclampsia?

Ambulatory Blood Pressure Monitoring for Diagnosis and Management of Hypertension in Pregnant Women

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