Efficacy of behavioural activation in the treatment of negative symptoms in people with schizophrenia spectrum disorders: A systematic review

Muyambi, Kuda; Walsh, Sandra; Dan Bressington,; Gray, Richard; Dennis, Shaun; Brown, Ellie; Grimshaw, Marcus; Drummond, Joanne; Jones, Martin

doi:10.1016/j.ijnsa.2023.100132

Cited by 1 publication

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“…To date, there have been two studies that have examined the effectiveness of behavioural activation in treating negative symptoms. 26 The two studies reported that behavioural activation was efficacious in reducing negative symptoms. 27 28 As both studies were pre-postdesign, there is a need to consider conducting randomised controlled trials to establish the potential evidence base.…”

Section: Open Accessmentioning

confidence: 99%

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Australian trial of behavioural activation for people with schizophrenia experiencing negative symptoms: a feasibility randomised controlled trial protocol

Muyambi,

Walsh,

Dettwiller

et al. 2024

BMJ Open

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IntroductionNegative symptoms are frequently experienced by people with schizophrenia. People with negative symptoms often have impaired social functioning and reduced quality of life. There is some evidence that cognitive–behavioural therapy results in a modest reduction in negative symptoms. Behavioural activation may be an effective alternative treatment for negative symptoms.The study aims to examine the feasibility and acceptability of implementing a behavioural activation trial delivered in three community mental health services in South Australia to support adult consumers experiencing negative symptoms of schizophrenia.Method and analysisThis randomised controlled study will recruit a total of 60 consumers aged 18 years or above with mild-moderate negative symptoms of schizophrenia. The consumers will be randomly allocated to receive behavioural activation plus usual mental healthcare or usual mental healthcare alone. The intervention group will receive twelve 30 min sessions of behavioural activation, which will be delivered twice weekly over 6 weeks. In addition, we aim to recruit nine mental health workers from the three rural mental health services who will complete a 10-week online training programme in behavioural activation. Changes in negative symptoms of schizophrenia and depressive symptoms will be assessed at three time points: (a) at baseline, at 6 weeks and 3 month follow-ups. Changes in health-related quality of life (Short Form F36; secondary outcome) will be assessed at two time points: (a) at baseline and (b) immediately at postintervention after 6 weeks. At the end of the trial, interviews will be conducted with purposively selected mental health workers and consumers. Descriptive statistics and thematic analysis will be used to assess feasibility and acceptability.Ethics and disseminationThe findings from our feasibility study will inform the design of a fully powered randomised controlled trial to test the effectiveness of behavioural activation as a treatment for negative symptoms in schizophrenia. The study protocol was approved by the Central Adelaide Local Health Network Human Research Ethics Committee. The findings from this study will be disseminated through peer-reviewed scientific journals and conferences.Trial registration numberACTRN12623000348651p.

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Section: Open Accessmentioning

confidence: 99%

“…27 28 As both studies were pre-postdesign, there is a need to consider conducting randomised controlled trials to establish the potential evidence base. 26 However, a necessary first step is to undertake a feasibility trial to understand whether a fully powered randomised controlled trial is viable.…”

Section: Open Accessmentioning

confidence: 99%