Efficacy of B-mode ultrasound-based attenuation for the diagnosis of hepatic steatosis: a systematic review/meta-analysis

Hirooka, Masashi; Sunago, Kotarou; Nakamura, Yoshiko; Hirooka, Kana; Watanabe, Takao; Yoshida, Osamu; Terada, Yoshio; Abe, Masanori; Hiasa, Yoichi

doi:10.1007/s10396-022-01196-5

Cited by 9 publications

(3 citation statements)

References 46 publications

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“…The 0.74 value, which is close to the cutoff values for S2 and S3 determined by the Youden index, supports the notion that therapeutic interventions are warranted. In a meta-analysis conducted by the authors, the ATT, before it was improved to iATT, had the disadvantage of lower sensitivity than other ultrasound attenuation methods [ 45 ]. The reason for the lower diagnostic performance of the ATT is the use of the dual-frequency method wherein two frequencies are transmitted and received simultaneously as the algorithm for evaluating attenuation coefficients.…”

Section: Discussionmentioning

confidence: 99%

iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study

Hirooka,

Ogawa,

Koizumi

et al. 2024

J Gastroenterol

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Background Several preliminary reports have suggested the utility of ultrasound attenuation coefficient measurements based on B-mode ultrasound, such as iATT, for diagnosing steatotic liver disease. Nonetheless, evidence supporting such utility is lacking. This prospective study aimed to investigate whether iATT is highly concordant with magnetic resonance imaging (MRI)-based proton density fat fraction (MRI-PDFF) and could well distinguish between steatosis grades. Methods A cohort of 846 individuals underwent both iATT and MRI-PDFF assessments. Steatosis grade was defined as grade 0 with MRI-PDFF < 5.2%, grade 1 with 5.2% MRI-PDFF < 11.3%, grade 2 with 11.3% MRI-PDFF < 17.1%, and grade 3 with MRI-PDFF of 17.1%. The reproducibility of iATT and MRI-PDFF was evaluated using the Bland–Altman analysis and intraclass correlation coefficients, whereas the diagnostic performance of each steatosis grade was examined using receiver operating characteristic analysis. Results The Bland–Altman analysis indicated excellent reproducibility with minimal fixed bias between iATT and MRI-PDFF. The area under the curve for distinguishing steatosis grades 1, 2, and 3 were 0.887, 0.882, and 0.867, respectively. A skin-to-capsula distance of ≥ 25 mm was identified as the only significant factor causing the discrepancy. No interaction between MRI-logPDFF and MRE-LSM on iATT values was observed. Conclusions Compared to MRI-PDFF, iATT showed excellent diagnostic accuracy in grading steatosis. iATT could be used as a diagnostic tool instead of MRI in clinical practice and trials. Trial registration This study was registered in the UMIN Clinical Trials Registry (UMIN000047411).

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Section: Discussionmentioning

confidence: 99%

iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study

Hirooka,

Ogawa,

Koizumi

et al. 2024

J Gastroenterol

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“…of 14 convex transducer (1.0-4.0 MHz). Steatosis was categorised as absent or present and graded as mild, moderate or severe through B-mode ultrasound findings [62].…”

Section: Discussionmentioning

confidence: 99%

Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity

Aureli,

Recupero,

Mariani

et al. 2023

IJMS

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Vitamin B12 (or cobalamin) is an essential vitamin for DNA synthesis, fatty acid and protein metabolism as well as other metabolic pathways fundamental to the integrity of cells and tissues in humans. It is derived from the diet and mostly stored in the liver. Its deficiency has been associated with metabolic derangements, i.e., obesity, glucose intolerance, increased lipogenesis and metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH). However, data with regard to body weight across the whole spectrum (from underweight to severe obesity) in children and young individuals are scarce. The present study aims to describe the association between serum total vitamin B12 and body mass index (BMI) ranging from underweight to severe obesity in a large population of children, adolescents and young adults. This study also investigates associations with visceral adiposity, glucose and lipid metabolism and liver dysfunction. A cross-sectional, single-centre study was conducted at the Paediatrics and Endocrinology units of the ”Bambino Gesù Children Hospital”, a tertiary referral institution for eating disorders. Clinical charts were reviewed and 601 patients aged from 5 to 25 years were enrolled in order to analyse anthropometric, auxological, clinical, biochemical and liver ultrasound data using robust statistical approaches. Analyses were adjusted for potential confounders. A reduction in serum total B12 levels was associated with a linear increase in body weight, as expressed by WHO BMI SDS (r = −0.31, p < 0.001, BCa 95% −0.38, −0.24). Lower B12 levels were associated with higher waist circumference but only in pubertal girls (r = −0.33, p = 0.008, BCa 95% −0.53, −0.11). Hepatic insulin resistance was higher in males with lower B12 levels (B = −0.003 (−0.007, −0.0001), p = 0.039), but not in females, whereas whole-body insulin resistance was unaffected. Serum lipid profiles (total, HDL and LDL cholesterol and triglycerides) were not influenced by serum cobalamin levels. However, lower cobalamin levels were associated with higher grading of ultrasound-scored hepatic steatosis (ptrend = 0.035). Lastly, both AST and ALT showed a significant and direct correlation with total B12 levels in underweight (r = 0.22 and 0.24, p = 0.002 and <0.001, respectively) and severely obese subjects (r = 0.24 and 0.32, p = 0.002 and <0.001). In conclusion lower vitamin B12 levels are associated with higher body weight, adiposity and with worse metabolic health in a large population of children, adolescents and young adults.

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“…Clinically, the lesion hardness of CMT is positively correlated with fibrosis, and the accurate evaluation of the lesion degree of CMT is very important for the judgment of treatment and prognosis. A non-invasive, lowrisk, accurate and repeatable diagnostic method is of great significance for the diagnosis and treatment of pediatric muscular torticollis [7][8][9][10] .…”

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confidence: 99%

Meta-Analysis of Diagnostic Value of HSY5-Ultrasound in Children with Muscular Torticollis

Hu,

Tu,

Lin

et al. 2023

IJPS

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Hu et al.: Clinical Utility of Ultrasound ElastographyTo investigate the potential clinical utility of ultrasound elastography in the diagnosis and management of infants with congenital muscular torticollis. We conducted searches in PubMed, Embase, Web of Science and Cochrane library databases and limited the search time from the database was created in April 2023. Articles were screened according to inclusion and exclusion criteria. RevMan (version5.3) is used for meta-analysis. The study results were presented using either standard mean difference or mean difference as statistical measures to compare the difference between two groups and 95 % confidence intervals for consecutive outcomes. Chisquare test was used to calculate I 2 to detect the heterogeneity between studies and then appropriate effect models were selected according to I 2 or p values. Publication offset was evaluated using funnel plots. Of the 5 studies included. The years of publication ranged from 2013 to 2021, with sample sizes ranging from 20 to 120. Ultrasonic measurements of sternocleidomastoid muscle thickness (mean difference was 0.57, 95 % confidence intervals was -0.42-0.72, p<0.001). The A/U ratio of sternocleidomastoid muscle measured by ultrasound was (mean difference was -0.45, 95 % confidence interval was -1.56-0.66, p=0.42). Ultrasound imaging may be a useful adjunct to the evaluation of B ultrasound in sternocleidomastoid muscle infants. However, further high quality clinical trial studies are needed to obtain stronger clinical evidence.

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Efficacy of B-mode ultrasound-based attenuation for the diagnosis of hepatic steatosis: a systematic review/meta-analysis

Cited by 9 publications

References 46 publications

iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study

iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study

Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity

Meta-Analysis of Diagnostic Value of HSY5-Ultrasound in Children with Muscular Torticollis

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