2003
DOI: 10.1590/s0037-86822003000100010
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Efficacy of azithromycin in the treatment of cutaneous leishmaniasis

Abstract: The present open pilot study was conducted to assess the efficacy of azithromycin for the treatment of patients with cutaneous leishmaniasis in Araçuaí and Varzelândia, MG. Twenty-four patients with less of six months of disease evolution were treated after clinical examination, Montenegro test and a biopsy. The treatment schemes consisted of oral doses of 500 mg per day for 3, 5 and 10 days and of 1000 mg for two days. A clinical control was performed monthly and treatment cycles were repeated when necessary … Show more

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Cited by 37 publications
(30 citation statements)
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“…Reports from the New and Old World show divergent results, with cure rates of 85% [91] and 27.6% [92], respectively.…”
Section: Alternative Drugsmentioning
confidence: 97%
“…Reports from the New and Old World show divergent results, with cure rates of 85% [91] and 27.6% [92], respectively.…”
Section: Alternative Drugsmentioning
confidence: 97%
“…The first line-therapy for ACL, according to WHO recommendation, is the pentavalent antimony compounds such as meglumine antimoniate (Glucantime) (Minodier and Parola 2007). Other treatments for cutaneous leishmaniasis (CL) are antifungal agents, azithromycin, paromomycin ointment, and physical treatment like cryotherapy (cryosurgery) (Prata et al 2003;Dogra et al 1990;Al majalio and Routh 1997;Esfandiarpour and Alavi 1997). In recent researches ZS has been studied to treat the disease, although there are some controversies regarding the efficacy of ZS in the treatment of cutaneous leishmanniasis (Firooz et al 2004;Iraji et al 2004).…”
Section: Introductionmentioning
confidence: 99%
“…In an open trial in Brazil, it cured 16 out of 20 patients with cutaneous ulcers caused by Leishmania (Viannia) braziliensis, however, cure time, doses and cycles number presented high variability (PRATA et al, 2003). In the same location; three out of four old individuals with mucosal involvement presented clinical cure after several cycles with this drug (SILVA-VERGARA et al, 2004).…”
Section: Introductionmentioning
confidence: 99%