Efficacy of Autologous Platelet Concentrates in Regenerative Endodontic Treatment: A Systematic Review of Human Studies

Metlerska, Joanna; Fagogeni, Irini; Nowicka, Alicja

doi:10.1016/j.joen.2018.09.003

Cited by 45 publications

(50 citation statements)

References 78 publications

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“…Murray [ 9 ] concluded that both PRP and PRF induce apical closure more frequently than blood-clot revascularization; however, the studies included in this review were conducted on either vital or nonvital teeth, with no forest plots or risk of bias assessments carried out to consider the study as a meta-analysis. A recent systematic review of human studies by Metlerska et al [ 27 ] included 5 clinical trials and 21 case reports, concluding that APCs were successful in treating permanent teeth with root development. To our knowledge, no meta-analysis exists justifying the effectiveness of APCs in the management of young, immature, necrotic, permanent teeth.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Autologous Platelet Concentrates in Management of Young Immature Necrotic Permanent Teeth—A Systematic Review and Meta-Analysis

Panda

Mishra

Arbildo-Vega

et al. 2020

Cells

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The use of autologous platelet concentrates (APCs) in regenerative endodontic procedures is inconsistent and unclear. The aim of this meta-analysis was to evaluate the effectiveness of autologous platelet concentrates compared to traditional blood-clot regeneration for the management of young, immature, necrotic, permanent teeth. The digital databases MEDLINE, SCOPUS, CENTRAL, Web of Science, and EMBASE were searched to identify ten randomized clinical trials. The outcomes at postoperative follow-up, such as dentinal wall thickness (DWT), increase in root length (RL), calcific barrier formation (CB), apical closure (AC), vitality response (VR), and success rate (SR), were subjected to both qualitative synthesis and quantitative meta-analysis. The meta-analysis showed that APCs significantly improved apical closure (risk ratio (RR) = 1.17; 95% CI: 1.01, 1.37; p = 0.04) and response to vitality pulp tests (RR = 1.61; 95% CI: 1.03, 2.52; p = 0.04), whereas no significant effect was observed on root lengthening, dentin wall thickness, or success rate of immature, necrotic teeth treated with regenerative endodontics. APCs could be beneficial when treating young, immature, necrotic, permanent teeth regarding better apical closure and improved response to vitality tests.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of Autologous Platelet Concentrates in Management of Young Immature Necrotic Permanent Teeth—A Systematic Review and Meta-Analysis

Panda

Mishra

Arbildo-Vega

et al. 2020

Cells

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“…An electronic search was performed using MEDLINE (PubMed), Cochrane and Scopus’ (Metlerska et al . ). Example 4b : ‘A literature search was performed in the MEDLINE and EBSCOhost databases until June 2017 with no language restriction’ (Nagendrababu et al . 2019c).…”

Section: Explanation and Endodontic Examples Of Items In The Prisma Fmentioning

confidence: 97%

“…An electronic search was performed using MEDLINE (PubMed), Cochrane and Scopus’ (Metlerska et al . ).…”

Section: Explanation and Endodontic Examples Of Items In The Prisma Fmentioning

confidence: 97%

“…Five were randomized trials, and the others were case reports’ (Metlerska et al . ). Example 6d : ‘We included six studies (916 participants with 988 teeth) reported in English. All the studies had high risk of bias.…”

Section: Explanation and Endodontic Examples Of Items In The Prisma Fmentioning

confidence: 97%

“…Example 6c: 'The search resulted in 426 titles from all databases, and 26 studies met the inclusion criteria. Five were randomized trials, and the others were case reports'(Metlerska et al 2019).…”

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Preferred reporting items for systematic reviews and meta‐analyses for abstracts: best practice for reporting abstracts of systematic reviews in Endodontology

et al. 2019

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An abstract is a brief overview of a scientific, clinical or review manuscript as well as a stand‐alone summary of a conference abstract. Scientists, clinician–scientists and clinicians rely on the summary information provided in the abstracts of systematic reviews to assist in subsequent clinical decision‐making. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) for Abstracts checklist was developed to improve the quality, accuracy and completeness of abstracts associated with systematic reviews and meta‐analyses. The PRISMA for Abstracts checklist provides a framework for authors to follow, which helps them provide in the abstract the key information from the systematic review that is required by stakeholders. The PRISMA for Abstracts checklist contains 12 items (title, objectives, eligibility criteria, information sources, risk of bias, included studies, synthesis of results, description of the effect, strength and limitations, interpretation, funding and systematic review registration) under six sections (title, background, methods, results, discussion, other). The current article highlights the relevance and importance of the items in the PRISMA for Abstracts checklist to the specialty of Endodontology, while offering explanations and specific examples to assist authors when writing abstracts for systematic reviews when reported in manuscripts or submitted to conferences. Strict adherence to the PRISMA for Abstracts checklist by authors, reviewers and journal editors will result in the consistent publication of high‐quality abstracts within Endodontology.

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Dental Pulp Stem Cells in Endodontics: Advances, Applications, and Challenges

Ahmed,

Duncan,

El-Karim

et al. 2023

Handbook of Stem Cell Applications

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Efficacy of Autologous Platelet Concentrates in Regenerative Endodontic Treatment: A Systematic Review of Human Studies

Cited by 45 publications

References 78 publications

Effectiveness of Autologous Platelet Concentrates in Management of Young Immature Necrotic Permanent Teeth—A Systematic Review and Meta-Analysis

Effectiveness of Autologous Platelet Concentrates in Management of Young Immature Necrotic Permanent Teeth—A Systematic Review and Meta-Analysis

Preferred reporting items for systematic reviews and meta‐analyses for abstracts: best practice for reporting abstracts of systematic reviews in Endodontology

Dental Pulp Stem Cells in Endodontics: Advances, Applications, and Challenges

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