Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft

Centeno, Christopher J.; Pitts, John; Al‐Sayegh, Hasan; Freeman, Michael

doi:10.1155/2014/370621

Cited by 149 publications

(166 citation statements)

References 46 publications

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“…Our findings are consistent with prior investigations demonstrating a favorable safety profile for the percutaneous use of BMC and MSC injections for the treatment of orthopaedic conditions of the peripheral and axial joints and surrounding tissues [7,9,13,14]. The SAE rates observed in our study were substantially lower than those reported for more invasive orthopaedic surgical procedures [22].…”

Section: Discussionsupporting

confidence: 92%

“…While there have been several publications that have described the safety and efficacy of bone marrow derived stem cell therapies for orthopaedic applications [1,7,[9][10][11][12][13]15], to our knowledge the current investigation is the most comprehensive report of its kind, following the largest population for the longest time, and incorporating an analysis of the relative safety of several different approaches. Our findings are consistent with prior investigations demonstrating a favorable safety profile for the percutaneous use of BMC and MSC injections for the treatment of orthopaedic conditions of the peripheral and axial joints and surrounding tissues [7,9,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Institutional Review Board oversight for the registry protocol was provided by a U.S. Office of Human Research Protections registered organization (#IRB00002637). Outcomes and efficacy of each procedure have been reported previously [2,8,13,16]. Prior to each procedure, physicians discussed risks, benefits, and alternatives to the procedure.…”

Section: Participants and Settingsmentioning

confidence: 99%

“…The results of these studies, bolstered by the results of in vitro and animal studies, indicate that bone marrow derived MSCs carry little to no risk of malignant transformation, and that they are likely safe for use in human orthopaedic applications [4,7,[13][14][15]. However, no large scale investigations exist with long-term patient follow-up where all complications have been reported, adjudicated, and classified.…”

Section: Introductionmentioning

confidence: 99%

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A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions

Centeno

Al‐Sayegh

Freeman

et al. 2016

International Orthopaedics (SICOT)

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130

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Introduction The purpose of the present investigation is to report on detailed complications among a much larger group of 2372 orthopaedic patients treated with stem cell injections who were followed in a treatment registry for up to nine years. Methods All patients underwent an MSC-based, percutaneous injection treatment of an orthopaedic condition between December 2005 and September 2014 at one of 18 clinical facilities. Treated areas of the body included the knee, hip, ankle/foot, hand/wrist, elbow, shoulder, and spine. The patients were followed prospectively via enrollment in a treatment registry. Patients were followed prospectively at one, three, six and 12 months, and annually thereafter, using an electronic system, ClinCapture software.Results A total of 3012 procedures were performed on 2372 patients with follow-up period of 2.2 years. A total of 325 adverse events were reported. The majority were pain postprocedure (n = 93, 3.9 % of the study population) and pain due to progressive degenerative joint disease (n = 90, 3.8 % of the study population). Seven cases reported neoplasms, a lower rate than in the general population. The lowest rate of adverse events was observed among patients injected with BMC alone. Conclusion Lowest rate of adverse events was among those patients receiving BMC injections alone, but the higher rate of AEs for BMC plus adipose and cultured cells was readily explained by the nature of the therapy or the longer followup. There was no clinical evidence to suggest that treatment Electronic supplementary material The online version of this article

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Participants and Settingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions

Centeno

Al‐Sayegh

Freeman

et al. 2016

International Orthopaedics (SICOT)

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130

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“…82,89-91 Centeno et al 89 compared the treatment of osteoarthritis with injections of BMC combined with PRP and platelet lysate, with and without adipose tissue. The data indicates that there is no significant difference between the 2 groups.…”

mentioning

confidence: 99%

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

Venkatesh¹

2017

ATROA

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Abbreviations: ACI, autologous chondrocyte implantation;MSCs, mesenchymal stem cells; PRP, platelet-rich plasma; BMC, autologous bone marrow concentrate; TKR, total knee replacement IntroductionOsteoarthritis is a form of arthritis described as a degenerative joint disease that results from the breakdown of articular cartilage and underlying subchondral bone.1,2 Cartilage is firm, rubbery, protein substance that serves as a "cushion" between the bones, providing a smooth, gliding surface for joint motion. As the cartilage breaks down, it causes pain, swelling, stiffness and problems moving the joint.3 Therefore, Osteoarthritis is a chronic disease and a major cause of disability, characterized by irreversible cartilage degeneration, bony changes of the joints, deterioration of tendons and ligaments, and inflammation of the synoviumas shown in Figure 1. 4 An initial degeneration, known as the 'pre-OA' state may be reversible spontaneously or through preventive measures, however, if not stopped, the disease progresses to later stages which results in loss of articular cartilage surface integrity, break down of bone and osteophyte formation.3,5 OA can affect any joint, but it most often occurs in the knee, hip, lower back and neck, small joints in the finger and base of the big toe ( Figure 2). 6,7Osteoarthritis of the knee is the most common chronic condition affecting all races, gender and ages, but known to be the most common in elderly and obese people. 8,9 The knee acts as a conduit for transferring body weight essential for normal human mobility and the menisci is known to maintain the normal function of the knee, distribute load, lubricate the joint and provide joint stability. Injury to the meniscus from ageing cartilage, repetitive activity or trauma results in pain, limits movement and can accelerate the occurrence and development of OA. In general, partial or complete meniscectomy causes OA of the knee. 8,10,11 While the prevalence of OA increases with age and causes significant decline in the quality of life of individuals above the age of 65, there is increasing evidence of OA in younger population as a result of prior injuries such as anterior cruciate ligament tear or meniscal tears. 8,12,13 Figure 1 Comparison schematic between healthy knee and arthritic knee.Osteoarthritis affects about 237 million of the population, of which an estimated 9 million people alone in United States suffer from symptomatic knee osteoarthritis and it is predicted that an additional 19 million people will be affected by arthritis by 2020. 14-17The incidence of chondral defects is frequent with sporting injuries, and in elderly patients specifically 10% of population over the age of 55 years have troublesome knee pain, and of those, 25% are severely disabled.18 Depending on disease severity, management ranges from conservative treatment to surgical intervention, including total knee replacement. 14,19 In recent years the number and cost of TKR has increased dramatically between 2001 and 2012 from 305,000 to 610,000 procedu...

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Intraarticular injection autologous platelet‐rich plasma and bone marrow concentrate in a goat osteoarthritis model

Wang¹,

Zhai

Fei

et al. 2018

Journal Orthopaedic Research

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To evaluate the effects of intraarticular injections of autologous platelet-rich plasma (PRP) or bone marrow concentrate (BMC) on osteoarthritis (OA), 24 adult goats were equally divided into control (Ctrl), saline (NS), PRP, and BMC groups, and OA was induced by surgery in NS, PRP, and BMC groups. Autologous PRP and BMC were obtained from whole blood and bone marrow aspirates, respectively. The data revealed, platelets were increased in BMC by 1.8-fold, monocytes by 5.6-fold, TGF-β1 by 7.7-fold, and IGF-1 by 3.6-fold (p < 0.05), and platelets were increased in PRP by 2.9-fold, and TGF-β1 by 3.3-fold (p < 0.05). From the sixth week post-operation, saline, PRP, and BMC were administered by intraarticular injection once every 4 weeks, three consecutive times. After the animals were sacrificed, inflammatory cytokines in the synovial fluid was measured, and bone and cartilage degeneration progression was observed by macroscopy, histology, and immunohistochemistry. Compared with the NS group, the level of inflammatory cytokines was reduced in the PRP and BMC groups (p < 0.05). Histologically, delayed cartilage degeneration and higher levels of extracellular matrix (ECM) were observed in both PRP and BMC treated groups (p < 0.05). Furthermore, the BMC group showed greater cartilage protection and less ECM loss than the PRP group (p < 0.05). In summary, this study showed that intraarticular injection of autologous PRP and BMC has therapeutic efficacy in a goat osteoarthritis model, with the greater benefit in terms of cartilage protection being observed in the BMC-treated group than PRP. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

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Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft

Cited by 149 publications

References 46 publications

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

Intraarticular injection autologous platelet‐rich plasma and bone marrow concentrate in a goat osteoarthritis model

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