Efficacy of Ashwagandha and Brahmi Extract on Alcohol Withdrawal Syndrome in Laboratory Rats

Mishra, Akhilesh; Gupta, Pushpit; Kalr, Bhupinder Singh; Tiwa, Yogesh Kumar

doi:10.3923/ijp.2020.343.350

Cited by 3 publications

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“…In a previous study, Ashwagandha (500 mg/kg, oral) showed a significant increase in locomotor activity in the open field at 6th hour of alcohol withdrawal [ 35 ]. Mishra et al also reported that rats treated with Ashwagandha (3.75 mg of withanolide glycosides per kg body weight) and Brahmi (10 mg of bacosides per kg body weight) were effective in controlling agitation and seizures and showed similar results [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study

et al. 2021

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Patients with alcohol use disorder experience alcohol withdrawal syndrome due to the sudden cessation of alcohol. This study was designed to evaluate the protective effect of Ashwagandha and Brahmi on alcohol withdrawal in rats. Thirty rats of either sex were taken and randomly divided into 6 groups (n = 5). Their normal diet was replaced by a modified liquid diet (MLD). Ethanol was added gradually except in the MLD group for a period of 21 days and withdrawn suddenly. Four treatment groups were administered Ashwagandha (3.75 mg of withanolide glycosides per kg body weight), Brahmi (10 mg of bacosides per kg body weight), Ashwagandha + Brahmi (3.75 mg withanolide glycosides + 10 mg bacosides per kg body weight) orally and diazepam (1 mg/kg body weight, i.p.) 45 min before alcohol withdrawal. Rats were assessed for behavioural changes (agitation score and stereotypic behaviour), anxiety and locomotor activity at 2nd and 6th hours of alcohol withdrawal. Pentylenetetrazol (PTZ) kindling seizures were assessed at 6th hour of alcohol withdrawal. Ashwagandha and Brahmi alone and in combination significantly reduced the behavioural changes in alcohol withdrawal rats at 2nd hour and their combination in 6th hour. Ashwagandha and Brahmi suppressed PTZ kindling seizures effectively and improved locomotory activity at 2nd hour and 6th hour of alcohol withdrawal. Reduction in anxiety was significant among Ashwagandha at 2nd hour and the combination group at 2nd and 6th hour. The results were comparable to diazepam. Ashwagandha and Brahmi have beneficial effects in controlling the behavioural changes, anxiety and seizures in alcohol withdrawal symptoms in rats and improved locomotory activity.

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Section: Discussionmentioning

confidence: 99%

Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study

et al. 2021

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“…This perspective is particularly relevant for women of childbearing age, concerned about the impact of medications on maternal and fetal health (5). This study explores the effectiveness of Ashwagandha and Sweet Basil, combined with cinnamon, as a tea blend in managing anxiety in young adults, focusing on women of childbearing age (6). By evaluating the effects of these herbal combinations on anxiety and considering factors like palatability and acceptability, this research contributes to the knowledge base on natural mental health interventions (7).…”

Section: Introductionmentioning

confidence: 99%

Sensory Appeal and Anxiety Reduction: A Study on Ashwagandha, Sweet Basil, and Cinnamon Tea Blends

Shahid,

Iftikhar,

Israr

et al. 2023

JHRR

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Background: Anxiety disorders are prevalent among young adults, especially women of childbearing age, necessitating the exploration of alternative therapeutic interventions. The present study investigates a specialized tea blend combining Ashwagandha, Sweet Basil, and cinnamon for potential anxiety alleviation in this demographic. Objective: The primary objectives encompassed (1) formulating a tea blend combining Ashwagandha and Sweet Basil with cinnamon, (2) evaluating its nutritional and sensory attributes, and (3) assessing its potential to reduce anxiety using the Beck Anxiety Inventory (BAI). Methods: Ingredients were procured from Faisalabad's native market and crushed to formulate two tea variants. The study was conducted over 21 days with 30 participants, divided into three groups: G0 (Control), G1 (Ashwagandha and Cinnamon), and G2 (Sweet Basil and Cinnamon). Anxiety levels were assessed using BAI at the start and end of the intervention. Results: Nutritional analysis indicated variations in moisture, ash, crude fat, crude protein, and NFE content among formulations. Sensory evaluations pointed to G1 having superior aroma, texture, flavor, and overall acceptability, while G2 excelled in appearance. BAI assessments, though indicative of potential anxiety-reducing effects, were not conclusively significant due to sample size constraints. Conclusion: The tea formulations exhibited promising relationships between sensory appeal, nutritional value, and potential anxiety-reducing effects. However, further studies with larger sample sizes and longer intervention periods are warranted for more definitive insights. The study contributes to the exploration of natural interventions for anxiety management, emphasizing the nexus between sensory experiences, nutrition, and emotional well-being.

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A Complex Interplay between Nutrition and Alcohol use Disorder: Implications for Breaking the Vicious Cycle

White,

Sirohi

2024

CPD

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Abstract:: Approximately 16.5% of the United States population met the diagnostic criteria for substance use disorder (SUD) in 2021, including 29.5 million individuals with alcohol use disorder (AUD). Individuals with AUD are at increased risk for malnutrition, and impairments in nutritional status in chronic alcohol users can be detrimental to physical and emotional well-being. Furthermore, these nutritional deficiencies could contribute to the never-ending cycle of alcoholism and related pathologies, thereby jeopardizing the prospects of recovery and treatment outcomes. Improving nutritional status in AUD patients may not only compensate for general malnutrition but could also reduce adverse symptoms during recovery, thereby promoting abstinence and successful treatment of AUD. In this review, we briefly summarize alterations in the nutritional status of people with addictive disorders, in addition to the underlying neurobiological mechanisms and clinical implications regarding the role of nutritional intervention in recovery from alcohol use disorder.

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Efficacy of Ashwagandha and Brahmi Extract on Alcohol Withdrawal Syndrome in Laboratory Rats

Cited by 3 publications

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Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study

Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study

Sensory Appeal and Anxiety Reduction: A Study on Ashwagandha, Sweet Basil, and Cinnamon Tea Blends

A Complex Interplay between Nutrition and Alcohol use Disorder: Implications for Breaking the Vicious Cycle

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