Efficacy of Articaine: A New Amide Local Anesthetic

Efficacy of 4 % Articaine and 2 % Lidocaine: A clinical study

“…Santos et al [49] reported that transient increase or decrease in blood pressure and oxygen saturation were observed but they were neither clinically significant nor statistically significant. Several authors Malamed et al [8,9], Brkovic et al [18], Colombini et al [43], Martinez et al [52], Elad et al [55], Vasconcellos et al [56] were in accordance with our findings. On the contrary Moore et al [40] reported that only A100 treatment group showed a statistically significant decrease in systolic blood pressure at the completion of testing A100 decreased 2.6 mmHg, p = 0.0153).…”

“…The number of repeat anesthetic procedures was greater when using 2 % Lidocaine (13.33 %). On the other hand, this difference in the total amount of anesthetic solution used for Articaine is 1.73 ± 0.11 ml and that for Lidocaine is 1.86 ± 0.41 ml and the value is similar to the value reported by Malamed et al [8] in their multi-centric study of 1,325 adult patients. However, the difference in both the mean frequency and amount of solution used for re-anesthesia of the surgical zone failed to reach statistical significance.…”

“…In our study intraoperative VAS of 1-10 for Articaine was 1.88 ± 1.18 while for Lidocaine it was 2.45 ± 1.68 but these results are statistically not significant. This is in accordance with Malamed et al [8,9], Rebolledo et al [50]. Gregorio et al [54] reported the intra operative analgesia evoked by Articaine may be explained by its ability to readily diffuse through tissues due to the presence of thiophene group in the molecule which increases liposolubility.…”

“…Malamed et al [8,9] reported overall incidence of adverse events in the combined studies was 22 % for Articaine and 20 % Lidocaine of which paresthesia was 0.9 %, hypoesthesia 0.7 %, headache 0.55 %, infection 0.45 %, rash and pain 0.3 %. Potonick et al [45] reported that although 4 % Articaine is more effective, they suggested that it may be worth considering replacing the 4 % Articaine with 2 % Articaine solution as the risk of an intravenous injection of the anesthetic solution during the induction of inferior alveolar nerve block and the possibility that the 4 % Articaine solution may increase the incidence of non surgical paresthesia.…”

“…Lidocaine being the safest, most commonly used anesthetic agent, with encouraging results referring to greater efficacy of Articaine [8,9], only few studies [24-26, 35, 36, 44, 45, 50, 51, 53, 55, 59] reported about the comparison of Lidocaine and Articaine and in India only few studies on third molar surgery are conducted, we decided to compare the solution of 2 % Lidocaine in 1:100,000 with 4 % Articaine in 1:100,000 in surgical removal of impacted third molars.…”