Efficacy of Arabica Versus Robusta Coffee in Improving Weight, Insulin Resistance, and Liver Steatosis in a Rat Model of Type-2 Diabetes

Abstract

The effects of chronic coffee exposure in models of type 2 diabetes mellitus (T2D) is scarcely studied, and the efficacy of the main coffee species has never been compared. We tested the hypothesis that long-term consumption of arabica and robusta coffee may differentially delay and affect T2D development in Zucker diabetic fatty rats. Three study groups received either chow mixed with arabica or robusta instant coffee (1.8% w/w) or unsupplemented chow food for 10 weeks. Both coffee species reduced liver triglyceride content and area under the curve of fasting and postprandial insulin. At study end, plasma adiponectin, total cholesterol and high density lipoprotein levels were higher in the robust group compared with both arabica and control groups. The liver gene expression of Glucose-6-phosphatase, catalytic subunit (G6pc) and Mechanistic target of rapamycin (mTOR) in robusta and Cpt1a in both coffee groups was downregulated. In conclusion, long-term consumption of both coffee species reduced weight gain and liver steatosis and improved insulin sensitivity in a rat model of T2D. Robusta coffee was seemingly superior to arabica coffee with respect to effects on lipid profile, adiponectin level and hepatic gene expression.

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

“…These foods often contain more nutrients, such as nuts rich in both 3-n PUFA and polyphenols, and are easier to administer and could also be enriched with additional nutraceutics, such as yogurt with antioxidants. Table 5 shows some functional foods, presented in this review, that are capable of modifying the expression of adipokines, myokines, and cardiokines [52,53,79,81,83,156,157,177]. Therefore, the action of functional foods will have to be further investigated.…”

“…In vitro experiments have demonstrated that caffeine promotes APN protein synthesis activating PPARγ [80]. Additionally, coffee intake improves of glycemic parameters, inflammation state, and reduces cardiovascular risk [81,82].…”

How Does LC/MS Compare to UV in Coffee Authentication and Determination of Antioxidant Effects? Brazilian and Middle Eastern Coffee as Case Studies

“…Though there are more than 120 species of Coffea , coffee is brewed mainly from the seeds of Coffea arabica L. and C. canephora L. var. robusta or C. robusta [ 3 ]. Arabica coffee is preferred by most consumers due to a more intense aroma and flavor compared to robusta [ 4 ].…”

Is Rheumatoid Arthritis Related to Coffee Consumption in Korea? A Nationwide Cross-Sectional Observational Study

“…Two-thirds of the coffee consumed in Korea was Arabica, and one-third was Robusta. Robusta coffee had a superior effect on lipid profile and adiponectin level to that of Arabica coffee [22], and lipid metabolism is related to inflammation, potentially explaining the absence of association between coffee and the high prevalence of RA in Korea, unlike previous observational studies in Western countries. In addition, residues of solvents (benzene, trichloroethylene, carbon tetrachloride, acetone, ammonium hydroxide, sulfuric acid, ethyl acetate, and methylene chloride) used in the process of extracting caffeine from coffee for decaffeinated coffee might have influenced the development of RA.…”