Efficacy of aprotinin in children undergoing craniofacial surgery

Abstract

Aprotinin decreased blood transfusion requirements in pediatric patients undergoing craniofacial reconstruction, thereby reducing the risks associated with exposure to banked blood components.

Intraoperative Tranexamic Acid Reduces Blood Transfusion in Children Undergoing Craniosynostosis Surgery

“…Our findings are comparable with those of previous trials 19,20,22 in cardiac or scoliosis surgery in children. Neilipovitz et al 19 reported that TXA reduced the volume of PRBCs by 30% compared with a placebo group in children undergoing posterior spinal fusion for scoliosis.…”

“…23 A few studies 13,16,17,20,23 have shown that intraoperative TXA administration led to less blood loss compared with a placebo group for different types of surgery. Nevertheless, some researchers 19,22 did not report a significant difference in blood loss using TXA or aprotinin, despite a significant decrease in total blood transfusion in the treated patients. In our current study, the amount of intraoperative and total blood loss tended to decrease in patients receiving TXA compared with placebo (51.4 Ϯ 28.3 vs. 61.1 Ϯ 16.8 ml/kg and 64.0 Ϯ 32.4 vs. 76.0 Ϯ 16.1 ml/kg, respectively).…”

“…22,23 D'Errico et al 22 showed that the amount of intraoperative blood for transfusion was significantly lower in children treated with aprotinin compared with placebo (32 Ϯ 25 vs. 52 Ϯ 34 ml/kg). Duran de la Fuente et al 23 performed a comparative study using TXA and saline in pediatric cranial remodeling surgery.…”

“…In children undergoing craniofacial surgery, only two studies 22,23 showed the effectiveness of an antifibrinolytic drug in reducing intraoperative blood loss. We hypothesized that TXA would decrease the number of blood transfusions compared with placebo.…”

Pediyatrik Kraniofasiyal Cerrahide Anestezik Yaklaşım ve Kan Kaybını Azaltan Yöntemler

“…Faktör VII preparatının fiyatı ise yüksektir. D'Errico ve arkadaşları 52 aprotininle kraniyal vault operasyonlarında transfüzyon ihtiyacının azaldığını rapor etmişlerdir. Ahmet Z ve arkadaşları 53 çocuklarda (1 ay ve 3 yaş arası) aprotinin uygulamışlar ve kan transfüzyonunu kontrol grubu ile karşılaştırmışlardır.…”