Efficacy of antimicrobial photodynamic therapy with chloro-aluminum phthalocyanine on periodontal clinical parameters and salivary GSH and MDA levels in patients with periodontitis

Silva, Davi Neto de Araújo; Silva, Natália Teixeira da; Sena, Israel Alexandre de Araújo; Azevedo, Marcela Letícia da Silva; Júnior, Francisco Leonardo da Silva; Silva, Régia Carla Medeiros da; Vasconcelos, Roseane Carvalho; Moraes, Maiara de; Longo, João Paulo Figueiró; Araújo, Aurigena Antunes de; Martins, Ana Rafaela Luz de Aquino

doi:10.1016/j.pdpdt.2020.101843

Cited by 9 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For malondialdehyde, no statistically significant differences were observed between groups (p > 0.05). 25…”

Section: Author/year Sample Apdt Protocol General Resultsmentioning

confidence: 99%

“…Therefore, the clinical protocol may vary according to laser dosimetry and the photosensitiser used. 35,36 Of the four studies selected for the present study, three used the aluminium-chlorine phthalocyanine (AlClPc) photosensitiser 5 μM (0.1 mL-300 s per periodontal site) 14,24,25 and one used toluidine blue 100 μg/mL (1 mL for 1 min). 9 Despite this difference in protocols, there was some similarity in the general results of the analysed studies, in which none of them showed beneficial effects that categorise the aPDT and SRP association as superior to conventional treatment.…”

Section: No Of Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Photodynamic therapy adjuvant to non‐surgical periodontal therapy: Systematic review of randomized clinical trials

Souza,

de Lima Dantas,

Souto

et al. 2023

Int J Dental Hygiene

View full text Add to dashboard Cite

ObjectivesTo systematically evaluate randomised controlled trials (RCTs) on whether adjuvant application of antimicrobial photodynamic therapy (aPDT) through the technique of irradiation in the external region of the periodontal pocket with optic‐fibre tip offers benefits to scaling and root planning (SRP).MethodsFive databases were searched by two independent reviewers according to pre‐specified eligibility criteria up to April 2023. No restrictions regarding date of publication, language and minimum follow‐up period were imposed. The Cochrane Collaboration's Risk of Bias tool (RoB 2.0) was used for quality appraisal and Grading of Recommendations, Assessment, Development and Evaluation for assessing the certainty of evidence.ResultsA total of 1388 publications were identified and reviewed for eligibility. Four of them fulfilled the inclusion criteria. The sample consisted of a total of 83 patients with periodontitis. In these, 330 periodontal sites were evaluated. The clinical findings of the majority of the included studies demonstrated that patients who received the association of aPDT + RAR with the protocol evaluated here, obtained clinical results similar to patients who received only the SRP alone. In none of the evaluated RCTs, clinical advantages were observed that would categorise this aPDT protocol as superior to conventional treatment.ConclusionApplying aPDT after SRP with external irradiation of the periodontal pocket does not seem to result in any clinical benefit compared to the use of SRP alone in patients with periodontitis.

show abstract

“…For malondialdehyde, no statistically significant differences were observed between groups (p > 0.05). 25…”

Section: Author/year Sample Apdt Protocol General Resultsmentioning

confidence: 99%

Section: No Of Patientsmentioning

confidence: 99%

Photodynamic therapy adjuvant to non‐surgical periodontal therapy: Systematic review of randomized clinical trials

Souza,

de Lima Dantas,

Souto

et al. 2023

Int J Dental Hygiene

View full text Add to dashboard Cite

show abstract

“…Many studies showed that PDT could significantly reduce PPD and gain more CAL and SBI than SRP alone. 79,91 However, some studies showed no significant improvement in PPD and CAL 92,93 but significantly reduced GI, 94 BOP, 95 sulcus bleeding index (SBI), 74 and the flow rate of sulcus fluid. 96…”

Section: Clinical Effects Of the Pdt-assisted Srpmentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

show abstract

“…This suggests that higher GSH concentrations are associated with better periodontal condition ( 37 ). Similarly, several studies have observed significantly higher levels of MDA detected in saliva in patients with periodontitis who have not received periodontal treatment ( 38 ), and anti-photodynamic therapy can increase the content of GSH in saliva while decreasing the content of MDA ( 39 ). Furthermore, human periodontal ligament fibroblasts treated with butyrate also showed a decrease of GSH and GPX4 ( 34 ).…”

Section: Nrf2 Is Involved In the Regulation Of Periodontal Diseasementioning

confidence: 99%

The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis

Luo²,

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

Nuclear factor E2-related factor 2(Nrf2) is a transcription factor that mainly regulates oxidative stress in the body. It initiates the expression of several downstream antioxidants, anti-inflammatory proteins and detoxification enzymes through the Kelch-like ECH-associating protein 1 (Keap1) -nuclear factor E2-related factor 2(Nrf2) -antioxidant response element (ARE) signaling pathway. Its anti-apoptosis, anti-oxidative stress and anti-inflammatory effects have gradually become the focus of periodontal disease research in recent years. In this paper, the structure and function of Nrf2 pathway and its mechanism of action in the treatment of periodontitis in recent years were analyzed and summarized, so as to further clarify the relationship between Nrf2 pathway and oxidative stress in the occurrence and development of periodontitis, and to provide ideas for the development of new treatment drugs targeting Nrf2 pathway.

show abstract

Efficacy of antimicrobial photodynamic therapy with chloro-aluminum phthalocyanine on periodontal clinical parameters and salivary GSH and MDA levels in patients with periodontitis

Cited by 9 publications

References 32 publications

Photodynamic therapy adjuvant to non‐surgical periodontal therapy: Systematic review of randomized clinical trials

Photodynamic therapy adjuvant to non‐surgical periodontal therapy: Systematic review of randomized clinical trials

Photodynamic therapy in periodontitis: A narrative review

The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis

Contact Info

Product

Resources

About