Efficacy of antimicrobial activity of slow release silver nanoparticles dressing in post-cardiac surgery mediastinitis

Totaro, Pasquale; Rambaldini, Manfredo

doi:10.1510/icvts.2008.188870

Cited by 46 publications

(28 citation statements)

References 4 publications

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“…Further treatment of the biofilms without daily transfers (i.e., the batch experiments) resulted in a gradual reduction in viable cell numbers within the biofilms, as independently observed by our group (data not shown) and Percival et al (28), but were in disagreement with previously reported clinical observations (12,33). In contrast, prolonged treatment with daily transfer decreased the efficacies of most tested dressings, resulting in a recovery of the biofilms after 7 days that was consistent with clinical observations (12,41,42). Thus, measuring and predicting the antimicrobial effectivenesses of different silver dressings can be improved by the use of the daily transfer assay to more closely mimic the actual wound bed environment.…”

Section: Discussionsupporting

confidence: 86%

Impact of Silver-Containing Wound Dressings on Bacterial Biofilm Viability and Susceptibility to Antibiotics during Prolonged Treatment

Kostenko

Lyczak

Turner

et al. 2010

Antimicrob Agents Chemother

134

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The long-term antimicrobial efficacy of silver dressings against bacterial biofilms was investigated in a 7-day treatment in vitro model where the protein-rich medium was refreshed daily in order to mimic the conditions found in a wound bed. The use of plate-to-plate transfer assays demonstrated measurable differences in the effectivenesses of several silver dressings on the viability of biofilm bacteria and their susceptibility to antibiotics. Whereas after the first day of treatment, all dressings used resulted in a significant reduction in the number of viable cells in the biofilms and disruption of the biofilm colonies, during prolonged treatment, the efficacy of dressings with hydrophilic base materials diminished with daily transfers, and bacterial populations recovered. For dressings with hydrophobic base materials, the level of efficacy correlated with the silver species loaded. Biofilm bacteria, which survived the initial silver treatment, were susceptible to tobramycin, ciprofloxacin, and trimethoprim-sulfamethoxazole, in contrast to untreated biofilms, which were highly tolerant to the same antibiotics. This acquired susceptibility was unaffected by the longevity of pretreatment with the silver dressings but depended on the dressing used. The antimicrobial efficacy of the dressings correlated with the type of the dressing base material and silver species loaded.

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Section: Discussionsupporting

confidence: 86%

Impact of Silver-Containing Wound Dressings on Bacterial Biofilm Viability and Susceptibility to Antibiotics during Prolonged Treatment

Kostenko

Lyczak

Turner

et al. 2010

Antimicrob Agents Chemother

134

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“…In all four patients negative cultures were obtained within a maximum of 72 h and patients were discharged within a maximum of 20 days. 63 Hussain et al 64 evaluated the acute toxicity of different metallic nanoparticles in vitro using a rat liver derived cell line (BRL 3A) (ATCC, CRL-1442 immortalized rat liver cells). Different sizes of silver nanoparticles (15 or 100 nm) were evaluated for their potential toxicity.…”

Section: Toxicitymentioning

confidence: 99%

Potential use of silver nanoparticles on pathogenic bacteria, their toxicity and possible mechanisms of action

Durán¹,

Marcato²,

Conti³

et al. 2010

J. Braz. Chem. Soc.

409

224

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As propriedades da prata são conhecidas há muitos anos. Recentemente, as nanopartículas de prata têm chamado a atenção por sua atividade antimicrobiana que oferece a possibilidade de uso com propósitos médicos e de higiene. Estas nanopartículas de prata em diferentes formulações, com diferentes formas e tamanhos, exibem atividades antimicrobianas diferentes. Entretanto, os mecanismos da atividade antimicrobiana de íons e de nanopartículas, assim como sua toxicidade em tecidos humanos não estão totalmente esclarecidos. Esta revisão avalia o uso potencial de nanopartículas de prata no controle de patogênicos com ênfase sobre sua ação contra bactérias patogênicas, sua toxicidade e possíveis mecanismos de ação.The antimicrobial properties of silver have been known for thousands of years. Recently, silver nanoparticles have gained attention because of their antimicrobial activity which offers the possibility of their use for medical and hygiene purposes. Indeed, silver nanoparticles in different formulations and with different shapes and sizes exhibit variable antimicrobial activity. However, the mechanisms of antimicrobial activity of silver ions and silver nanoparticles, and their toxicity to human tissues are not fully characterized. This review evaluates the potential use of silver nanoparticles to control pathogens with emphasis on their action against pathogenic bacteria, their toxicity and possible mechanisms of action.

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“…The use of a silver-impregnated dressing (with or without concomitant vacuum apparatus) in post-operative mediastinitis with continued positive cultures despite surgical debridement and antibiotic therapy showed conversion to negative cultures and ultimate wound closure with the silver dressing [64]. Another analysis compared mediastinitis rates after cardiac surgery when a silver dressing was used routinely and found a significant decrease in the incidence of infection compared with standard dressings, although the methodology of this study was less rigorous [65].…”

Section: Surgical Incisionsmentioning

confidence: 99%

Use of Silver in the Prevention and Treatment of Infections: Silver Review

Politano

Campbell

Rosenberger

et al. 2013

Surgical Infections

165

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Background: The use of silver for the treatment of various maladies or to prevent the transmission of infection dates back to at least 4000 b.c.e. Medical applications are documented in the literature throughout the 17th and 18th centuries. The bactericidal activity of silver is well established. Silver nitrate was used topically throughout the 1800s for the treatment of burns, ulcerations, and infected wounds, and although its use declined after World War II and the advent of antibiotics, Fox revitalized its use in the form of silver sulfadiazine in 1968. Method: Review of the pertinent English-language literature. Results: Since Fox's work, the use of topical silver to reduce bacterial burden and promote healing has been investigated in the setting of chronic wounds and ulcers, post-operative incision dressings, blood and urinary catheter designs, endotracheal tubes, orthopedic devices, vascular prostheses, and the sewing ring of prosthetic heart valves. The beneficial effects of silver in reducing or preventing infection have been seen in the topical treatment of burns and chronic wounds and in its use as a coating for many medical devices. However, silver has been unsuccessful in certain applications, such as the Silzone heart valve. In other settings, such as orthopedic hardware coatings, its benefit remains unproved. Conclusion: Silver remains a reasonable addition to the armamentarium against infection and has relatively few side effects. However, one should weigh the benefits of silver-containing products against the known side effects and the other options available for the intended purpose when selecting the most appropriate therapy.

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Efficacy of antimicrobial activity of slow release silver nanoparticles dressing in post-cardiac surgery mediastinitis

Cited by 46 publications

References 4 publications

Impact of Silver-Containing Wound Dressings on Bacterial Biofilm Viability and Susceptibility to Antibiotics during Prolonged Treatment

Impact of Silver-Containing Wound Dressings on Bacterial Biofilm Viability and Susceptibility to Antibiotics during Prolonged Treatment

Potential use of silver nanoparticles on pathogenic bacteria, their toxicity and possible mechanisms of action

Use of Silver in the Prevention and Treatment of Infections: Silver Review

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