Efficacy of antigen dosage on the hepatitis B vaccine response in infants born to hepatitis B-uninfected and hepatitis B-infected mothers

Kang, Guodong; Ma, Fuyin; Chen, Haiping; Yang, Yunkai; Guo, Shaohong; Wang, Zhiguo; Liang, Xiaofeng; Li, Li; Cui, Fuqiang; Zhang, Longhua

doi:10.1016/j.vaccine.2015.06.081

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…Therefore, the current study provided an alternative explanation for the clinical observation that the newborns of only HBsAg-positive mothers are less likely to become chronically infected, especially after NAs treatment. Meanwhile, our study also supported the notion that only HBsAg positive does not inhibit the immune response of the progeny vaccination [ 18 ]. Besides, KEGG pathway analysis of all dysregulated genes in the fetal liver of two groups of mice showed that intrauterine exposure to HBsAg affected the metabolic function of the liver, which indicated that HBsAg might affect the function of glucose and lipid metabolism in liver cells.…”

Section: Discussionsupporting

confidence: 86%

“…Indeed, poor vaccination effects and more chronic HBV infection in offspring have been observed after intrauterine exposure to HBsAg [ 15–17 ]. However, there is no statistical difference in anti-HBs titre and response rate between the offspring born to women with HBsAg positive alone and those without HBV infection, suggesting that the immune response to the vaccine in offspring may not be inhibited by HBsAg [ 18 ]. Furthermore, a recent study showed that intrauterine exposure to HBsAg may trigger a state of “trained immunity” in infants, which is manifested by promoted innate immune maturation and T-helper 1 cells (Th1) development [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Solely HBsAg intrauterine exposure accelerates HBV clearance by promoting HBs-specific immune response in the mouse pups

Ning

Wang

Zheng

et al. 2022

Emerging Microbes & Infections

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Chronic hepatitis B virus (HBV) infection due to perinatal mother-to-infant transmission (MTIT) remains a serious global public health problem. It has been shown that intrauterine exposure to HBV antigens might account for the MTIT-related chronic infection. However, whether hepatitis B surface antigen (HBsAg) intrauterine exposure affected the offspring’s immune response against HBV and MTIT of HBV has not been fully clarified. In this study, we investigated the effects and the potential mechanisms of the HBsAg intrauterine exposure on the persistence of HBV replication using a solely HBsAg intrauterine exposure mice model. Our results revealed that solely HBsAg intrauterine exposure significantly accelerated the clearance of HBV when these mice were hydrodynamically injected with pBB4.5-HBV1.2 plasmids after birth, which may be due to the increased number of HBs-specific CD8 + T cells and interferon-gamma secretion in the liver of mice. Mechanismly, HBsAg intrauterine exposure activated antigen-presenting dendritic cells, which led to the generation of antigen-specific cellular immunological memory. Our data provide an important experimental evidence for the activation of neonatal immune response by HBsAg intrauterine exposure.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Solely HBsAg intrauterine exposure accelerates HBV clearance by promoting HBs-specific immune response in the mouse pups

Ning

Wang

Zheng

et al. 2022

Emerging Microbes & Infections

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“…Vaccination is also the most effective measure to reduce the global incidence of hepatitis B. Compared to other health care interventions, vaccination is, in terms of cost-effectiveness, an economically advantageous option [103]. In 1991, the WHO recommended that all countries introduce a policy of universal hepatitis B vaccination to prevent and control HBV infection.…”

Section: 1-prevention Of Congenital and Perinatal Infections In Lomentioning

confidence: 99%

“…Maternal antiviral therapy [152] Infant Hepatitis B vaccine (3 dose-regime) [103] and Hepatitis B Ig prophylaxis [103].…”

Section: Fundingmentioning

confidence: 99%

Congenital and perinatally-acquired infections in resource-constrained settings

Madrid

Varo

Sitoe

et al. 2016

Expert Review of Anti-infective Therapy

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This review aims to summarize the burden of congenital and perinatal infections and the main challenges for their control in resource-limited settings. Articles were identified through the main electronic databases and cover the period 1971-2016. Expert commentary: Estimates from low and middle-income countries indicate that the burden of congenital infections may be higher in these regions than in industrialized countries. As preventive and curative strategies are available to tackle some of these infections, efforts at the international and national levels must be made to implement those and thus reduce their burden in resource-limited countries.

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“…The results of the above two studies showed that the positive rate of anti-HBs decreased rapidly during the period from 1 to 3 years old and gradually stabilized after about 4 years old. In addition, the status of maternal immunization [9], large for gestational age [10], dosing schedule [11], vaccinate dosage [12] and mother's educational background [13]. However, there is still an immense absence of more objective factors in uencing the response level associated with the individuals themselves, such as their nutrition condition and the method of birth.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Factors Affecting the Expression of Anti-HBs in Children in Hunan Province

Tan

Dong

et al. 2021

Preprint

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Background and objectives Vaccine is the most essential avenue to prevent hepatitis B infection in infants and preschool children in China, with the largest populations carrying hepatitis B virus in the world. This study aimed to evaluate the factors affecting the response level of anti-HBs in children, with a view to provide instructions for hepatitis B prevention clinically. MethodsThe children taking physical examinations in the Third Xiangya Hospital from January 2013 to April 2020 were recruited. Telephone follow-up were adopted to collect further information. Univariate logistic regression was used to analyse the relationship between age and anti-HBs expression. After grouping by age and anti-HBs expression, we used chi-square test and T test to compare the difference between positive and negative antibody expression in each age subgroup. The meaningful variables (P<0.10) in chi-square test and T test were assessed with collinearity and chosen for univariate and multivariate logistic regression analysis by the stepwise backward maximum likelihood method (αin=0.05, αout=0.10).ResultsA total of 5838 samples (3362 males, 57.6%) were enrolled. The outcomes showed that the expression of anti-HBs was associated with age [OR=1.037(1.022-1.051)] in whole sample. Anemia[OR=0.392(0.185-0.835)], age[OR=2.542(1.961-3.295)] and Vit D[OR=0.977(0.969-0.984)] in 0.5-2.99 years subgroup, Zinc deficiency[OR=0.713(0.551-0.923] and age[OR=1.151(1.028-1.289)] in 3-5.99 years subgroup, Vit D[OR=0.983(0.971-0.995)] in 12-18 years subgroup had significant effect on the expression of anti-HBs. Conclusions This retrospective study illustrated that age, anaemia status, zinc deficiency and vitamin D were associated with the expression of anti-HBs in different age groups children, which could serve as a reference for the prevention of hepatitis.

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Efficacy of antigen dosage on the hepatitis B vaccine response in infants born to hepatitis B-uninfected and hepatitis B-infected mothers

Cited by 8 publications

References 32 publications

Solely HBsAg intrauterine exposure accelerates HBV clearance by promoting HBs-specific immune response in the mouse pups

Solely HBsAg intrauterine exposure accelerates HBV clearance by promoting HBs-specific immune response in the mouse pups

Congenital and perinatally-acquired infections in resource-constrained settings

Evaluation of Factors Affecting the Expression of Anti-HBs in Children in Hunan Province

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