Efficacy of an Oral Rehydration Solution Enriched with Lactobacillus reuteri DSM 17938 and Zinc in the Management of Acute Diarrhoea in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract

The efficacy of oral rehydration solution (ORS) enriched with Lactobacillus reuteri DSM 17938 and zinc in infants with acute gastroenteritis, is poorly defined. The aim of this double-blind, randomized, placebo-controlled study, was to assess the efficacy of an ORS enriched with Lactobacillus reuteri DSM 17938 and zinc (ORS+Lr&Z) in well-nourished, non-hospitalized infants with acute diarrhoea. Fifty one infants with acute diarrhoea were randomly assigned to receive either ORS+Lr&Z (28 infants, mean ± SD age 1.7 ± 0.7 years, 21 males), or standard ORS (ORS−Lr&Z; 23 infants, mean ± SD age 1.8 ± 0.7 years, 16 males). Stools volume and consistency were recorded pre- and posttreatment using the Amsterdam Infant Stool Scale and were compared between the two groups, as well as lost work/day care days, drug administration and need for hospitalization. Both groups showed reduction in the severity of diarrhoea on day two (p < 0.001) while, all outcomes showed a trend to be better in the ORS+Lr&Z group, without reaching statistical significance, probably due to the relatively small number of patients. No adverse effects were recorded. In conclusion, both ORS were effective in managing acute diarrhoea in well-nourished, non-hospitalized infants. ORS enriched with L. reuteri DSM 17938 and zinc was well tolerated with no adverse effects.

The Use of Probiotic with ORS and ORS Only in Children with Acute Diarrhea

“…19 However, healthy and non-hospitalised infants 6-36 months with acute diarrhea treated with ORS enriched with lactobacillus reuteri DSM17938 and zinc also showed reduced diarrheal episodes on day 2 (p<0.001). 25 Additional studies would be beneficial to determine the efficacy of probiotic in relation to patients age as there is significant variation.…”

Brazilian Portuguese version of the Amsterdam infant stool scale: a valid and reliable scale for evaluation of stool from children up to 120 days old

“…It can be applied for stool evaluation by parents, caregivers, and healthcare professionals. The AISS proved to be more useful to evaluate the bowel pattern of children who still use diapers, compared to the Bristol Stool Form Scale (BSFS) [2] and its use has also been increasing [5][6][7][8]. However, to be used in clinical practice and scientific investigations in Brazil, it is mandatory to perform the translation and cross-cultural adaptation process for Brazilian Portuguese language [9][10][11].…”

Pandemi Sırasında Çocuklarda Akut İshal ve Dehidratasyon

“…Akut ishalli bebeklerde ve çocuklarda, dehidratasyonun önlenmesi ve tedavisi için Oral Rehidratasyon Solüsyonu (ORS) önerilmektedir 28,33. ORS, dört saat aralıklarla az miktarda uygulanmasıyla hastaların %90'ında tedaviyi sağlamaktadır.…”