Efficacy of an Herbal Dietary Supplement (Smooth Move) in the Management of Constipation in Nursing Home Residents: A Randomized, Double-Blind, Placebo-Controlled Study

Bub, Sam; Brinckmann, J.A.; Cicconetti, Greg; Valentine, Barbara

doi:10.1016/j.jamda.2006.06.001

Cited by 31 publications

(38 citation statements)

References 11 publications

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“…In the first trial, use of an herbal mixture containing senna resulted in 4.14 more bowel movements on average over 4 weeks versus placebo (p = 0.017). 26 The second trial studied an herbal formulation containing an anthraquinone combined with the osmotic agent magnesium oxide; however, the reported benefit (5.6 ± 2.0 spontaneous bowel movements/wk in the study group v. 4.6 ± 2.5/wk in the placebo group; p = 0.049) did not change a global assessment of efficacy by caregivers. 27 Bisacodyl has not been evaluated in RCTs in older patients.…”

Section: Box 1: Evidence Used In This Reviewmentioning

confidence: 99%

Treatment of constipation in older people

Gandell

Straus

Bundookwala

et al. 2013

CMAJ

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Section: Box 1: Evidence Used In This Reviewmentioning

confidence: 99%

Treatment of constipation in older people

Gandell

Straus

Bundookwala

et al. 2013

CMAJ

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“…9,27-33 Nine (9) trials compared CHM with other CHM, 10,34-41 and 1 compared CHM with placebo. 6 Constipation was diagnosed using different diagnostic techniques: 23.8% (5=21) used TCM diagnostic criteria such as longer defecation period, hard stool, and difficult evacuation; 42.9% (9=21) used conventional diagnostic criteria such as the Rome II criteria; and 33.3% (7=21) used combined TCM and conventional diagnostic methods. The preparation form of CHM used also varied and included extracted decoctions, …”

Section: Chm For Treating Constipationmentioning

confidence: 99%

“…5 Older people are more likely to suffer from constipation, particularly those living in nursing homes and hospitals. 6 One (1) in 3 constipated patients in the United States seeks medical care. Americans spend approximately $6.9 billion on medical treatment for constipation 3 and more than $1 billion dollars on laxatives every year.…”

Section: Introductionmentioning

confidence: 99%

“…8 Therefore, researchers have started to explore the efficacy of alternative therapies, including traditional Chinese Medicine (TCM) for managing constipation. TCM modalities studied include Chinese herbal medicine (CHM), 6,[9][10][11][12] acupuncture and moxibustion, [13][14][15][16] acupressure and massage, [17][18][19][20] TCM diet therapy, 21,22 and auricular point therapy. [23][24][25] Some researchers reported that TCM improved constipation symptoms; others found no significant effects.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Traditional Chinese Medicine for the Management of Constipation: A Systematic Review

Lin

Dunning

et al. 2009

The Journal of Alternative and Complementary Medicine

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“…In the assessment of the safety of bisacodyl and Smooth Move ® , which contains senna (Cassia angustifolia Vahl), it was observed that most adverse events were gastrointestinal tract disorders (Kienzle-Horn et al, 2006;Bub et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Toxicology and safety of the tincture of Operculina alata in patients with functional constipation

Santos

Cunha

Fechine

et al. 2012

Braz. J. Pharm. Sci.

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The tincture of Operculina alata, popularly known as "tincture of jalapa", is used in Northeast Brazil to treat constipation and encephalic vascular accident, but it has not yet been adequately tested for safety and efficacy. The aim of this study was to evaluate the toxicology and safety of the tincture of O. alata in patients with functional constipation. This was a double-blind, randomized, placebo-controlled clinical trial. The study consisted of three phases: pre-treatment, treatment and post-treatment, each phase with duration of seven days. Arterial pressure, heart rate, body weight, adverse events, hematological, metabolic, liver and kidney functions were monitored. Forty patients were randomized to receive tincture of O. alata and 43 patients to receive placebo. There were statistical differences in the clinical aspects between groups, but these changes were not considered clinically significant. Adverse events were considered not serious and of mild intensity, especially dizziness, headache, abdominal pain and nausea. This clinical trial confirmed the safety of the tincture of O. alata in the pharmaceutical form and dosage tested, allowing the product to be safely used in a larger population for the assessment of its clinical efficacy. Uniterms:Operculina alata/pharmacognosy. Operculina alata/tincture/toxicological evaluation. Operculina alata/tincture/safety. Tincture of Jalapa see Operculina alata/tincture.A tintura de Operculina alata, popularmente conhecida como "tintura de jalapa", é usada no Nordeste do Brasil para tratar constipação intestinal e acidente vascular encefálico, mas sua eficácia e segurança ainda não foram confirmadas. O objetivo deste estudo foi avaliar a toxicologia e segurança da tintura de O. alata em pacientes com constipação intestinal funcional. Este foi um ensaio clínico duplo-cego, randomizado e controlado por placebo. O estudo consistiu de três fases: pré-tratamento, tratamento e pós-tratamento, cada fase com duração de sete dias. Foram monitorizados a pressão arterial, frequência cardíaca, peso corporal, eventos adversos e funções hematológica, metabólica, hepática e renal. Quarenta pacientes foram randomizados para receber tintura de O. alata e 43 pacientes para receber placebo. Houve diferenças estatísticas nos aspectos clínicos entre os grupos, contudo, estas mudanças não foram consideradas clinicamente significativas. Eventos adversos foram considerados não sérios e de leve intensidade, especialmente, cefaléia, tontura, dor abdominal e náusea. Este ensaio clínico confirmou a segurança da tintura de O. alata na forma farmacêutica e dosagem testada, permitindo que o produto seja testado em população maior para determinar sua eficácia clínica. Unitermos:Operculina alata/farmacognosia. Operculina alata/tintura/avaliação toxicológica. Operculina alata/tintura/segurança. Tintura de Jalapa see Operculina alata/tintura.

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Efficacy of an Herbal Dietary Supplement (Smooth Move) in the Management of Constipation in Nursing Home Residents: A Randomized, Double-Blind, Placebo-Controlled Study

Cited by 31 publications

References 11 publications

Treatment of constipation in older people

Treatment of constipation in older people

Efficacy of Traditional Chinese Medicine for the Management of Constipation: A Systematic Review

Toxicology and safety of the tincture of Operculina alata in patients with functional constipation

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