Efficacy of an anhydrous stannous fluoride toothpaste for relief of dentine hypersensitivity: A randomized clinical study

Tao, Danying; Ling, Martin R.; Feng, Xiping; Gallob, John; Souverain, Audrey; Yang, Wenjie; Alavi, Anousheh

doi:10.1111/jcpe.13305

Cited by 7 publications

(6 citation statements)

References 27 publications

(34 reference statements)

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“…Twice-daily use of a sensitivity relief toothpastes and mouthwashes containing stannous floride, potassium compounds and arginine is recommended for the management of DH [6,10]. The efficiency of toothpastes has been confirmed by studies [7,11].…”

Section: Introductionmentioning

confidence: 99%

“…Dentin hypersensitivity and the effect of treatment is often assessed by questionnaire, clinical exam, evaporative and tactile stimuli and visual analog scale [5,6,7] in order to mainly evaluate the oral health-related quality of life. In vitro studies about dentinal tubule occlusion after treatment gives a more precise information as bias may occur in clinical settings because of subjective decisions of patients as well as examiners.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Different Treatment Modalities on Dentinal Tubule Occlusion: An In Vitro Study

Elemek,

Ağralı,

Kılıç

et al. 2023

Preprint

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Purpose:The aim of this study was to assess the effect of mouthwash, diode laser and their combination on dentin hypersensitivity(DH). Methods:Forty dentin specimens were enabled and exposed dentinal tubules were created in vitro. They are assigned into four groups; control group, mouthwash with 1.4% dipotassium oxalate, combination of the same mouthwash and 810 nm diode laser, only diode laser. The occlusion of dentinal tubules were then observed with SEM. Results:The analysis resulted with the occlusion of dentinal tubules in all treatment groups but the results were more prominent in the combined treatment group. The number of open dentinal tubules in 100µm was significantly more in control group(p<0.05). Conclusion:Dentinal tubule occlusion was achieved both by mouthwash with 1.4% dipotassium oxalate and 810 nm diode laser. However, the combination of both treatments resulted with the best outcome and can be used in patients with dentin hypersensitivity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Different Treatment Modalities on Dentinal Tubule Occlusion: An In Vitro Study

Elemek,

Ağralı,

Kılıç

et al. 2023

Preprint

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“…Statistically significant reductions in pain and sensitivity were seen with the 0.454% w/w SnF 2 product compared with control dentifrices without 0.454% w/w SnF 2 , with relief of DH observed in subjects during short- and long-term use [ 13 – 17 ]. However, in Chinese population, subjects used dentifrices containing 0.454% w/w SnF 2 twice daily showed no significant advantage over negative or positive controls[ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a stannous fluoride dentifrice for relieving dentinal hypersensitivity in Chinese population: an 8-week randomized clinical trial

Li,

Yang,

Grimaldi

et al. 2024

Clin Oral Invest

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Objectives To compare the effectiveness of using a 0.454% stannous fluoride-containing dentifrice twice daily in relieving dentinal hypersensitivity (DH) in a Chinese population. Materials and methods This was a single-centre, randomized, controlled, examiner-blind, three-treatment-arm, parallel-group study in participants with clinically diagnosed DH. Subjects who met inclusion criteria (n = 197) were randomly allocated into 3 groups: test group (n = 66)—using a 0.454% stannous fluoride-containing dentifrice twice daily; positive control group (n = 64)—using a 5.0% calcium sodium phosphosilicate-containing dentifrice twice daily; negative control group (n = 67)—using a 1150 ppm of NaF dentifrice twice daily. Status of DH was assessed at week 4 and week 8 by the same independent examiner. Changes from baseline in Schiff sensitivity score, tactile threshold and Dentine Hypersensitivity Experience Questionnaire (DHEQ) score were analysed using analysis of covariance models. The DHEQ evaluated subject-perceived oral health-related quality of life (OHRQoL). Results Statistically significant improvements in mean Schiff scores (p < 0.0001 for all products at Weeks 4 and 8), tactile threshold (p < 0.0001 for test and negative control at Weeks 4 and 8: Week 4 p = 0.0040 and Week 8 p < 0.0001 for positive control) and all DHEQ scores (p < 0.01 for all groups) were observed. No statistically significant differences were observed in the adjusted mean between all dentifrices at both timepoints, potentially driven by a placebo effect. Forty-two treatment-emergent adverse events (TEAEs) were reported (n = 32 subjects), with 2 serious AEs (n = 1) in the test group. TEAEs were not considered treatment-related. Conclusions All groups demonstrated statistically significant improvements in Schiff score, tactile threshold and OHRQoL. However, due to a possible placebo effect in the negative control, there were no statistically significant differences between the dentifrices. Clinical relevance This study adds to the growing research exploring why the placebo effect is a common phenomenon in DH studies. Trial registration: ClinicalTrials.gov Identifier: NCT04950465.

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“…Examples of such evidence are triclosan/copolymer [7,8], stannous uoride [7,9], and Dual-Zinc + Arginine [10]. Furthermore, some products have also been e cacious in root caries reduction [11], dentin hypersensitivity management [12], and protection against abrasive or erosive challenges [13].…”

Section: Introductionmentioning

confidence: 99%

Toothpaste-related interests of Google users from different countries

Profio

Lotto

Aguirre

et al. 2022

Preprint

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Background The Internet is a growing source of knowledge and can provide information about oral health. This ecological study aimed to characterize the interests of Google users on toothpaste in different countries. Methods This longitudinal retrospective study analyzed the toothpaste-related interest of Google users from ten distinct countries between January 2004 and December 2020. The monthly variation in Relative Search Volume (RSV) and the main related queries were determined using Google Trends. Autoregressive Integrated Moving Average (ARIMA) forecasting models were built to establish the predictive RSV values for mouthwash for an additional 12 months. Auto-correlation plots and a general additive model (GAM) were used to diagnose trends and seasonality in RSV curves. Additionally, the influence of social isolation during the COVID-19 pandemics was analyzed. Results Although not detected by ACF and PACF analyses, the heuristic analysis showed an increase in the interest in toothpaste-related information in all countries, with a stable trend observed in the 12-month forecasts, except for the increases in the United Kingdom and South Africa. Also, GAM analyses demonstrated a non-significant monthly or quarterly seasonal influence on data. In addition, the social isolation of the COVID-19 pandemic did not influence the online information-seeking behavior of Google Search users linked to this topic. Discussion The heuristic analysis of the time series indicated an increase in the interest of Internet users in toothpaste between January 2004 and December 2020. This increase may reflect the population's growing autonomy for solving their own health problems. The Internet seems to be the most popular source of information. As such, this information may enable the implementation of specific public oral health policies and oral-care communications based on the population´s needs. Along these lines, information monitoring and improvements in oral health literacy may contribute to the reduction of currently existing social and economic barriers. Conclusion The interest of Google Search users in information about toothpaste increased in all ten countries. These trends were not influenced by the outbreak of the COVID-19 pandemic in most countries.

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Efficacy of an anhydrous stannous fluoride toothpaste for relief of dentine hypersensitivity: A randomized clinical study

Cited by 7 publications

References 27 publications

The Effect of Different Treatment Modalities on Dentinal Tubule Occlusion: An In Vitro Study

The Effect of Different Treatment Modalities on Dentinal Tubule Occlusion: An In Vitro Study

Efficacy of a stannous fluoride dentifrice for relieving dentinal hypersensitivity in Chinese population: an 8-week randomized clinical trial

Toothpaste-related interests of Google users from different countries

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