Efficacy of aloe vera mouthwash versus chlorhexidine on plaque and gingivitis: A systematic review

Abstract

ObjectivesThe present systematic review assessed the efficacy of aloe vera mouthrinse on plaque and gingival inflammation.MethodsA comprehensive search of PubMed, EMBASE, Scopus and Web of Science was conducted in February 2018 to identify all relevant studies using the following keywords: aloe vera, gingivitis, gingival inflammation, plaque‐induced gingivitis, periodontal health and plaque control. The eligibility criteria were all randomized clinical trials that assessed the efficacy of aloe vera mouthrinse in comparison to chlorhexidine on plaque and gingivitis. The risk of bias of the included studies was assessed using the Cochrane risk of bias assessment tool.ResultsSix randomized clinical trials comprising 1358 subjects were included in this systematic review. All included studies showed that aloe vera was effective in reducing plaque and gingival inflammation. Four studies found aloe vera as effective as chlorhexidine in reducing plaque scores, while two studies found chlorhexidine significantly more effective than aloe vera. With regard to gingival inflammation, three studies showed comparable results between aloe vera and chlorhexidine, while one study showed better results with chlorhexidine. Moreover, the results showed that aloe vera had no or very minimal side effects compared to chlorhexidine, which showed significant side effects including stains and altered taste sensation.ConclusionThe available evidence remains inconclusive but suggests that aloe vera mouthwash is comparable to chlorhexidine in reducing gingival inflammation but inferior to chlorhexidine in reducing plaque. These findings are preliminary and further high‐quality studies with adequate sample sizes are highly recommended.

Efficacy of propolis-based mouthwashes on dental plaque and gingival inflammation: a systematic review

“…Nevertheless, long term-use of CHX has been linked with numerous adverse effects including altered taste perception, staining of teeth and tongue, burning sensation and genotoxicity of buccal epithelial cells [ 5 , 6 ]. Consequently, pharmaceutical companies have long been attempting to formulate natural-derived oral care products [ 7 – 9 ]. Among these, propolis -a natural resinous material produced by honey bee- has recently been proposed as an alternative anti-plaque mouthwash [ 8 , 10 ].…”

O uso do aloe vera como coadjuvante no tratamento periodontal

“…Quando o assunto é inflamação, três estudos revelaram resultados comparáveis entre aloe vera e clorexidina e apenas um falou da superioridade da clorexidina. Um outro ponto muito positivo do Aloe Vera, é que diferente da clorexidina, ela não apresenta efeitos colaterais, como mancha nos dentes e alteração da sensação gustativa (Al-Maweri et al, 2019).…”

Aloe vera and health outcomes: An umbrella review of systematic reviews and meta‐analyses

“…We identified 698 articles, of which 582 articles were excluded during screening titles and abstracts and duplicated articles. We reviewed 116 full‐texts of which 20 studies were eligible including 10 systematic reviews and meta‐analyses with 71 unique outcomes (Ali & Wahbi, 2017; Al‐Maweri et al, 2019; Gao et al, 2016; Hong et al, 2018; Norman et al, 2017; Suksomboon, Poolsup, & Punthanitisarn, 2016; Wang et al, 2013; Worthington et al, 2011; Zhang et al, 2016; Zheng et al, 2014) and 10 qualitative systematic reviews (Al‐Maweri et al, 2019; Chen, Zhang, Li, Yang, & Liu, 2013; Farahnik, Sharma, Alban, & Sivamani, 2017; Farrugia, Burke, Haley, Bedi, & Gandhi, 2019; Fifi, Axelrod, Chakraborty, & Saps, 2018; Furness, Worthington, Bryan, Birchenough, & McMillan, 2011; Gupta & Versteeg, 2017; Hekmatpou, Mehrabi, Rahzani, & Aminiyan, 2019; Marous et al, 2018; Ramkumar & Rao, 2005) (Figure 1). Reasons for exclusions were described in detail, see Supporting Information 5.…”

“…Reasons for exclusions were described in detail, see Supporting Information 5. The included reviews published in 2005 to 2019, which all conducted in patients with indications of Aloe vera , except 1 study conducted in healthy participants (Al‐Maweri, Nassani, et al, 2019).…”