Efficacy of Allium sativum oil to alleviate tebuconazol-induced oxidative stress in the liver of adult rats

Abstract

The present study focused on the protective efficacy of Allium sativum oil (ASO) against tebuconazol (TEB)-induced oxidative stress in the liver of adult rats. Thirty-two rats were randomly divided into four groups of eight each: group I served as control rats, group II was treated with TEB (100 mg/kg bw), group III received ASO (5ml/kg bw). The animals of group IV were treated with TEB and ASO, during 4 weeks. The obtained results showed that TEB induced a significant change of some hematological parameters, including red blood cells (RBC), haemoglobin content (Hb), haematocrit (Ht), white blood cells (WBC) and platelet (Plt) compared to the control group. Moreover, while the total cholesterol levels and the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and γ-Glutamyltranspeptidase (γGT) significantly increased due to TEB administration, the concentrations of plasma total protein, albumin and triglyceride considerably decreased. Furthermore, the exposure to TEB significantly increased the malondialdehyde (MDA), protein carbonyl (PCO) and advanced oxidation protein products (AOPP) levels and decreased glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) activities in the hepatic tissues. The results were confirmed by the histological impairments. Besides, the co-administration of ASO improved the status of all studied parameters. Therefore, our investigation revealed that ASO had protective effects against TEB-induced liver injury, which could be attributed to its phenolic compounds.

STAT6-targeting antisense oligonucleotides against solitary fibrous tumor

“…Finally, to evaluate ASO-induced hepatotoxicity, serum levels of biomarkers alanine transaminase (ALT), aspartate transaminase (AST), albumin, and total bilirubin were measured. 56 As shown in Figure 5 D, no significant increases were observed in 993562- and 993563-treated groups for all four biomarkers, and only a moderate but not clinically precluding increase in serum ALT and AST levels (∼3- to 4-fold compared with PBS control) was observed in the 993523-treated group. Taken together, these results indicated that the selected SFT-ASOs 993523, 993562, and 993563 displayed acceptable in vivo tolerability profiles.…”

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

“…The formation of the histological sections was carried out according to the method described by Berrouague et al (27). The lung was dissected and immediately fixed in a 10% formalin solution, treated with a series of graded ethanol, and then embedded in paraffin (increased at 56/58°C).…”

Insecticidal effect of Eucalyptus globulus and Rosmarinus officinalis essential oils on a stored food pest Ephestia kuehniella (Lepidoptera, Pyralidea)

“…The province (department) of El-Tarf (North East of Algeria) runs along the Mediterranean over 90km. This coastline teems with wild medicinal and aromatic plants (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). This harmonious greenery contains ecosystem variables and maintains the ecological stability of the region, which led to several inventories and researches on the vegetation of this region like the works of (16) as well as (17).…”