Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer

Oba, Koji; Teramukai, Satoshi; Kobayashi, Mariko; Matsui, Takanori; Kodera, Yasuhiro; Sakamoto, Junichi

doi:10.1007/s00262-006-0248-1

Cited by 94 publications

(58 citation statements)

References 24 publications

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“…Those who took PSK showed a significant improvement in overall survival (RR 0.71; CI 0.55-0.90; P ¼ .006) and disease-free survival (RR 0.72; CI 0.58-0.90; P ¼ .003) [87]. Benefit of PSK was also demonstrated in a meta-analysis of 8,009 gastric cancer patients from eight randomized, controlled trials with an increased survival (HR 0.88; CI 0.79-0.98; P ¼ .0180) [88]. Specific clinical trials additionally cited an increase in disease-free survival rate for gastric cancer patients taking PSK with minimal toxicity [89].…”

Section: Immune Modulationmentioning

confidence: 90%

Dietary Supplement Use in Cancer Care: Help or Harm

Hardy

2008

Hematology/Oncology Clinics of North America

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Section: Immune Modulationmentioning

confidence: 90%

Dietary Supplement Use in Cancer Care: Help or Harm

Hardy

2008

Hematology/Oncology Clinics of North America

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“…For example, Popiela et al [34] evaluated the effects of adjuvant immunochemotherapy with the use of bacillus CalmetteGuérin, and 5-fluorouracil, adriamycin, and mitomycin C, and reported a 24 % risk reduction in patients with stage III or stage IV gastric cancer after curative resection. Oba et al [35] performed a meta-analysis of immunochemotherapy with polysaccharide K for gastric cancer after curative resection, and reported a 12 % risk reduction. Fujimoto et al [36] reported the effects of postoperative adjuvant immunochemotherapy with the polysaccharide sizofiran on the same population, and concluded that curative resection of gastric cancer resulted in a better prognosis when sizofiran was prescribed along with the antitumor drug.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of adjuvant immunochemotherapy with OK-432 after curative resection of gastric cancer: an individual patient data meta-analysis of randomized controlled trials

et al. 2015

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Background OK-432 has been used as a cancer treatment for 40 years, and the immunostimulatory effects of OK-432 therapy have been intensely investigated in Japan. Recently, it has received attention as a possible booster for cancer vaccine treatments. Our previous meta-analysis based on summary measures revealed a significant improvement in the survival of patients with curatively resected gastric cancer. However, it is impossible to exclude the possibility of bias due to several prognostic factors. Methods We collected individual data for patients with stage III or stage IV gastric cancer after curative resection from 14 trials that were identified in a previous metaanalysis. Immunochemotherapy with OK-432 was compared with treatment with standard chemotherapy on an intention-to-treat basis. The primary end point was overall survival. Stratified survival analyses were performed with the trial as the stratification factor. Subgroup analyses were also performed according to the potential prognostic factors, which included pathological factors, splenectomy, and delayed-type hypersensitivity. Results There were 796 and 726 patients in the OK-432 and control groups, respectively. The median overall survival was 42.6 months for the OK-432 group and 32.3 months for the control group. The overall hazard ratio was 0.88 (95 % confidence interval 0.77-1.00, p = 0.050). No factor showed a statistically significant interaction in the subgroup analyses. ConclusionsThe results suggest that immunochemotherapy treatment with OK-432 could have a borderline significant effect for patients with stage III or stage IV gastric cancer after curative resection.

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“…T. versicolor contains biologically active compounds with an enormous variety of chemical structures including the protein-bound PSP, B-1,3-B-1,4 glucans, tetracyclic triterpenoids of lanostane, fungisterol and B-sitosterol [10][11][12]. Furthermore, Polysaccharide-K (PSK) which can be obtained from mushrooms displays anticancer activity in laboratory studies and preliminary human researches [13,14]. Therefore, Trametes spp.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Antimicrobial Activity of Different Trametes versicolor Extracts on Some Clinical Isolates

Özgör¹,

Ulusoy²,

Celebier³

et al. 2016

HJBC

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Ö Z E T K linik önemi olan ve ciddi hastalıklara sebep olan türlere karşı yoğun ilaç kullanımı bu türlerde direnç gelişimini tetiklemektedir. İlerleyen yıllarda birçok antimikrobiyal ilaç etkisiz hale geleceğinden bu türlere karşı yeni potansiyel ilaçların keşfedilmesi gereklidir. Anahtar KelimelerTrametes versicolor, Antimikrobiyal aktivite, Antifungal aktivite, Klinik izolatlar. A B S T R A C TI ntensive drug uses against species which have clinical significance and cause severe diseases have triggered the development of resistance in these species. It is necessary to discover new potential drugs against clinical isolates because many antimicrobial drugs become ineffective in the coming years. In this research, we used different extracts from Trametes versicolor fruiting bodies for investigating antibacterial and antifungal activities on some clinical isolates. For this purpose, five bacterial species (Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) and a fungal species (Candida albicans) were selected as clinically important isolates and four different crude extracts (chloroform, water, ethyl acetate and ethyl alcohol) of Trametes versicolor were tried on these species in terms of antimicrobial sensitivity with disc diffusion method. Obtained data were analyzed using SPSS 14 software. At the result, some of extracts were found to have antimicrobial activity on clinical isolates although all extracts generally show antimicrobial effect. Chloroform extract was found to have the highest antimicrobial activity on S. aureus and E. faecalis while ethanol extract was observed as more effective on P. aeruginosa, E. coli, B. subtilis and C. albicans isolates. It can therefore be suggested that, some of Trametes versicolor extracts are promising antimicrobial agents.

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Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer

Cited by 94 publications

References 24 publications

Dietary Supplement Use in Cancer Care: Help or Harm

Dietary Supplement Use in Cancer Care: Help or Harm

The efficacy of adjuvant immunochemotherapy with OK-432 after curative resection of gastric cancer: an individual patient data meta-analysis of randomized controlled trials

Investigation of Antimicrobial Activity of Different Trametes versicolor Extracts on Some Clinical Isolates

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