Efficacy of adjuvant Chinese herbal formula treatment for chronic tinnitus: A retrospective observational study

Lin, Chia‐Hui; Kuo, Chun-En; Yu, Hao-Chang; Lai, Yu-Kai; Huang, Yu‐Chuen; Tsai, Ming-Yen

doi:10.1016/j.ctim.2015.01.002

Cited by 5 publications

(7 citation statements)

References 33 publications

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“…As an exploratory pilot study, the stepped rules of thumb is used for estimating the pilot sample size ( Whitehead et al, 2016 ; Bell et al, 2018 ). Although there is no previous study on BHT, we base the estimation of standardized effect size on two previous studies of compound TCM formula on chronic tinnitus ( Lin et al, 2015 ; Chen et al, 2018 ). Using a mean difference estimate of eight and an estimate of standard deviation of 11–20 in similar populations, the standardized effect size is about 0.4 to 0.7.…”

Section: Methodsmentioning

confidence: 99%

“…Many clinical studies on TCM treatment for tinnitus have been reported in recent decades. In Taiwan, a clinical trial on 21 patients has reported that a TCM formula Chai-Hu-Jia-Long-Gu-Mu-Li-Tang combined with Western medicine might have an additional effect on improving psychological sensation of tinnitus and sleep quality than Western medicine alone ( Lin et al, 2015 ). In Japan, Yoku-kan-san, a TCM herbal formula, was found to cure tinnitus in 2 weeks on a patient enduring such a problem for 3 years ( Okamoto et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

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A Chinese Medicine Formula (Bushen Huoxue Tongluo) for the Treatment of Chronic Subjective Tinnitus: A Study Protocol for a Pilot, Assessor-Blinded, Randomized Clinical Trial

et al. 2022

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Background: Tinnitus is a common problem worldwide. There is still no effective method to cure it. Traditional Chinese medicine (TCM) may be a potentially effective treatment approach for tinnitus. However, there is still no clinical trial with scientifically rigorous methodology to evaluate the treatment effect of TCM for tinnitus. Therefore, we propose a pilot study to inform the feasibility of a future full-scale RCT to establish the efficacy of TCM formula for tinnitus.Objectives: The aim of this study is to determine the feasibility of a full-scale RCT and explore whether a TCM formula (BHT) has an additional effect on improving tinnitus when compared to informative counseling alone.Design: An assessor-blinded, randomized, controlled clinical trial is used.Participants: Twenty-four patients with chronic subjective tinnitus will be enrolled.Interventions: The patients will be allocated randomly to receive a TCM formula (BHT, Bushen Huoxue Tongluo) and informative counseling or informative counseling alone. The oral BHT herbal granules will be taken twice per day continuously for 8 weeks.Main outcome measures: The primary outcomes include recruitment rate, intervention completion rate, and data completion rate to evaluate the feasibility. The secondary outcomes include Tinnitus Handicap Inventory, tinnitus functional index, tinnitus sensation level, self-rated visual analogue scale on tinnitus loudness and annoyance, Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale, and adverse event. The outcome measures will be collected at baseline, end of treatment, and 4-week follow-up.Discussion: This trial is currently ongoing and is recruiting patients. The expected study results will find some preliminary evidence about the clinical effectiveness of BHT on chronic tinnitus and will also determine if it is feasible to conduct a full-scale RCT of BHT and identify the necessary changes to the protocol if possible.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Chinese Medicine Formula (Bushen Huoxue Tongluo) for the Treatment of Chronic Subjective Tinnitus: A Study Protocol for a Pilot, Assessor-Blinded, Randomized Clinical Trial

et al. 2022

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“…Lin et al 16 showed the efficacy of adjuvant Chinese herbal formula, which contained a total of 11 herbs, in the treatment of chronic tinnitus. Lin et al 16 showed the efficacy of adjuvant Chinese herbal formula, which contained a total of 11 herbs, in the treatment of chronic tinnitus.…”

Section: Discussionmentioning

confidence: 99%

“…The application of Chinese herb in the treatment of tinnitus has been reported in several studies. Lin et al 16 showed the efficacy of adjuvant Chinese herbal formula, which contained a total of 11 herbs, in the treatment of chronic tinnitus. In a review, Enrico et al 18 show several Chinese herbs like Gingko biloba are effective in the treatment of tinnitus for long years.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis

Fan

Chen

et al. 2018

J of Cellular Biochemistry

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Objective This study aimed to investigate the efficacy of Chinese herb Cistanche Yishen granules (CYG) in the treatment of tinnitus for patients with chronic nephritis. Methods A total of 89 adult patients were diagnosed with chronic glomerulonephritis from January 2016 to December 2017. All the patients were randomly divided into two groups, such as the control group and the CYG group. The efficacy of tinnitus was determined using tinnitus handicap inventory (THI), Pittsburgh sleep quality index (PSQI), pure tone audiometry (PTA), speech reception threshold (SRT), and visual analog scale (VAS) for tinnitus loudness and annoyance. Results In both these two groups of patients, values of THI, PSQI, PTA, SRT, and VAS for tinnitus loudness and annoyance were significantly decreased after the treatment compared with those before treatment. However, all values in CYG group after the treatment were significantly lower than those in the control group. Conclusion CYG could apparently release the tinnitus symptoms in the patients with chronic nephritis. This study might give more clinical evidence for Cistanche in the treatment of tinnitus and give a new treatment method for the patients with tinnitus.

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“…COPD has three main characteristics: chronic lung inflammation, excessive mucus production, and coughing which causes difficulty in breathing [2]. The number of COPD patients is steadily increasing in recent years and is expected to become the third leading cause of death worldwide by 2030 [3]. The current clinical treatment drugs mainly include inhaled β2‐adrenoceptor agonists and glucocorticoids, but these drugs only have a superficial disease treatment effect on COPD and cannot change the decline of lung function.…”

Section: Introductionmentioning

confidence: 99%

An integrated approach based on ultra‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry, network pharmacology, and molecular docking to study the key effective compounds and mechanism of action of Platycodi Radix in the treatment of chronic obstructive pulmonary disease

Wang,

Pei,

Xie

et al. 2023

J of Separation Science

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Platycodi Radix (PR) is a valuable herb that is widely used in the treatment of chronic obstructive pulmonary disease in clinics. However, the mechanism of action for the treatment of chronic obstructive pulmonary disease remains unclear due to the lack of in vivo studies. Our study established a novel integrated strategy based on ultra‐performance liquid chromatography coupled with time‐of‐flight mass spectrometry, network pharmacology, and molecular docking to systematically analyze the tissue distribution and active compounds of PR in vivo and the therapeutic mechanism of chronic obstructive pulmonary disease. First, tissue distribution studies have shown that the lung is the organ with the highest distribution of PR compounds. Subsequently, network pharmacology results showed that the tumor necrosis factor signaling pathway, interleukin‐17 signaling pathway, and mitogen‐activated protein kinase signaling pathway were the critical mechanisms of PR against chronic obstructive pulmonary disease. Ultimately, molecular docking results showed that the key targets were stably bound to the corresponding active compounds of PR. Our study is of great significance for the screening of the key effective compounds and the study of the mechanism of action in traditional Chinese medicine and provides data to support the further development and utilization of PR.

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Efficacy of adjuvant Chinese herbal formula treatment for chronic tinnitus: A retrospective observational study

Cited by 5 publications

References 33 publications

A Chinese Medicine Formula (Bushen Huoxue Tongluo) for the Treatment of Chronic Subjective Tinnitus: A Study Protocol for a Pilot, Assessor-Blinded, Randomized Clinical Trial

A Chinese Medicine Formula (Bushen Huoxue Tongluo) for the Treatment of Chronic Subjective Tinnitus: A Study Protocol for a Pilot, Assessor-Blinded, Randomized Clinical Trial

Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis

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