Efficacy of Acitretin and Commercial Tanning Bed Therapy for Psoriasis

Carlin, Christopher S.; Callis, Kristina P.; Krueger, Gerald G.

doi:10.1001/archderm.139.4.436

Cited by 43 publications

(21 citation statements)

References 24 publications

(28 reference statements)

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“…Two instruments that do are the National Psoriasis Foundation-Psoriasis Score (NPF-PS) and the Beer Sheva Psoriasis Severity Score (BPSS). The NPF-PS and BPSS amalgamate physician and patient assessments and a patient questionnaire on specific signs and symptoms into a single score (Carlin et al, 2003;Gottlieb et al, 2003;Cohen et al, 2005Cohen et al, , 2008; we would question the validity of this and firmly believe that the different components should be kept separate. Furthermore, neither instrument has as yet been properly validated.…”

Section: Discussionmentioning

confidence: 99%

The Simplified Psoriasis Index (SPI): A Practical Tool for Assessing Psoriasis

Chularojanamontri

Griffiths

Chalmers

2013

Journal of Investigative Dermatology

101

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The Simplified Psoriasis Index (SPI) is a summary measure of psoriasis with separate components for current severity (SPI-s), psychosocial impact (SPI-p), and past history and interventions (SPI-i). It derives from the Salford Psoriasis Index but replaces Psoriasis Area and Severity Index (PASI) with a composite weighted severity score designed to reflect the impact of psoriasis affecting functionally or psychosocially important body sites. Two complementary versions are available, differing only in that current severity (SPI-s) is either professionally (proSPI-s) or patient self-assessed (saSPI-s). This study examined the criterion and construct validity and response distribution of proSPI-s, saSPI-s, and SPI-p in 100 patients with plaque psoriasis. A further 50 patients were assessed for test-retest reliability of these three components. Interrater reliability of proSPI-s was assessed in 12 patients, each assessed by 12 assessors (144 assessments). There was close correlation between PASI and proSPI-s (r=0.91); SPI-p was closely correlated with the Dermatology Life Quality Index (r=0.89). Strong intrarater (proSPI-s, saSPI-s, SPI-p, and SPI-i) and interrater (proSPI-s) reliability was demonstrated (all intraclass correlation coefficients >0.75). There were wide response distributions for all three components. We believe that both professional (proSPI) and self-assessed (saSPI) versions can readily be introduced into routine clinical practice.

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Section: Discussionmentioning

confidence: 99%

The Simplified Psoriasis Index (SPI): A Practical Tool for Assessing Psoriasis

Chularojanamontri

Griffiths

Chalmers

2013

Journal of Investigative Dermatology

101

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“…Studies have reported faster healing of psoriatic skin lesions with the combined use of acitretin and UVB than with UVB alone. In a study by Carlin et al (EG C), the combination of acitretin 25 mg/daily with daily visits to the solarium (UVB proportion 5%, UVA proportion 7 – 12%) resulted in a PASI 75 score in 59% and a PASI 90 score in 47% of patients [386]. A study by Ozdemir et al with 60 patients confirmed these results.…”

Section: Systemic Therapymentioning

confidence: 92%

“…For combination therapy, one grade A 2 study [383], six grade B studies [176, 277, 290, 382, 384, 385], and one grade C study were included [386]. The efficacy of acitretin reported in the included studies varied greatly.…”

Section: Systemic Therapymentioning

confidence: 99%

S3 – Guidelines on the treatment of psoriasis vulgaris (English version). Update

Nast

Boehncke

Mrowietz

et al. 2012

J Deutsche Derma Gesell

250

247

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Psoriasis vulgaris is a common and often chronic inflammatory skin disease. The incidence of psoriasis in Western industrialized countries ranges from 1.5% to 2%. Patients afflicted with severe psoriasis vulgaris may experience a significant reduction in quality of life. Despite the large variety of treatment options available, surveys have shown that patients still do not received optimal treatments. To optimize the treatment of psoriasis in Germany, the Deutsche Dermatologi sche Gesellschaft (DDG) and the Berufsverband Deutscher Dermatologen (BVDD) have initiated a project to develop evidence-based guidelines for the management of psoriasis. They were first published in 2006 and updated in 2011. The Guidelines focus on induction therapy in cases of mild, moderate and severe plaque-type psoriasis in adults including systemic therapy, UV therapy and topical therapies. The therapeutic recommendations were developed based on the results of a systematic literature search and were finalized during a consensus meeting using structured consensus methods (nominal group process).

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“…28 However, the available data support that there is no difference in safety and outcomes between hospital-or office-based phototherapy and phototherapy in the home. 71,72 They advocate limiting home phototherapy to only those patients with overwhelming difficulties in traveling to the hospital for treatment. 30 Despite cautionary tales, home UVB therapy is prescribed for approximately 5% of psoriasis patients worldwide (with some variation by country).…”

Section: Clinical Datamentioning

confidence: 99%