Efficacy of acellular dermal matrix and autogenous connective tissue grafts in the treatment of gingival recession defects among Asians

Abstract

ADM and sCTG yield similar outcomes when used in the treatment of GR defects.

Acellular dermal matrix and subepithelial connective tissue grafts for root coverage: A systematic review

“…[ 42 ] The ADM product used was AlloDerm ® , except in one study where the product was not specified. [ 50 ] Of the studies that provided the ADM orientation, the number of studies (eight) where the connective tissue side was placed toward the tooth treated was nearly equal to the number (seven) that placed the basement membrane side toward the tooth. In ten studies, amoxicillin was prescribed,[ 6 10 20 39 40 41 44 48 49 52 ] and in one, doxycycline hyclate was prescribed postoperatively.…”

“…[ 42 ] All but one[ 6 ] prescribed chlorhexidine rinses post-operatively for varying lengths or time. Six studies[ 10 20 40 41 42 50 ] used root conditioning with tetracycline as part of the surgical protocol; one[ 39 ] used ethylenediaminetetraacetic acid.…”

“…Eleven studies reported the mean root coverage in mm. The mean difference was -0.03 mm (95% confidence interval [CI]: -0.26, 0.21; P = 0.83) In Taiyeb's study, with a 3-month follow-up,[ 50 ] the mean difference was 1 mm (95% CI: 0.20, 1.80; P = 0.01). De Souza's study reported a 12-month follow-up[ 40 ] with a mean difference of -0.15 mm (95% CI: -0.81, 0.5; P = 0.66).…”

“…De Souza's study reported a 12-month follow-up[ 40 ] with a mean difference of -0.15 mm (95% CI: -0.81, 0.5; P = 0.66). For the studies with the 6-month follow-up,[ 6 10 40 42 44 46 47 48 49 50 52 ] the mean difference was -0.11 mm (95% CI: -0.33, 0.11; P = 0.31). The data overall exhibited moderate heterogeneity[ 53 ] with an I 2 value of 40% [ ].…”

“…[ 20 41 46 49 51 ] The remainder of the studies did not find statistically significant differences between the treatment modalities. [ 6 10 39 40 42 43 44 45 47 48 50 52 ] The finding of this meta-analysis should be tempered by the substantial heterogeneity of the studies. The mechanism by which ADMG could increase KT has not been identified.…”