Efficacy of a topical formulation containing MIA (Melanoma Inhibitory Activity) ‐ Inhibitory peptides in a case of recalcitrant vitiligo in combination with UV exposure

Abstract

Introduction: Vitiligo is an acquired chronic pigmentation disorder of the skin. Even if the role of the immune system seems to be well established, new pathogenetic hypothesis are rising in these years. It has been recently suggested by the development of an animal model that a protein called Melanoma Inhibitory Activity (MIA) is involved in the pathogenesis of vitiligo. This protein interacts with the adhesion molecules expressed on the melanocytes causing its detachment from extracellular matrix proteins and creating the depigmented macules. A topical preparation based on oligopeptides able to inhibit the actions of the MIA protein has been introduced to the market, claiming activity on vitiligo. Patient concerns and diagnosis: A patient affected by non-segmental vitiligo for 10 years, recalcitrant to any treatment (such as steroids, immunomodulators, kellin, UVB-NB and UVA) came to our observation. Interventions: We used this topical preparation containing the MIA inhibitors peptides in selected areas (face and sides of the trunk) leaving untreated other areas as control (legs and arms). The patient was required to be sun exposed or to have some UVA sessions during the treatment to stimulate the melanocytes replications. Outcomes: After 9 months of treatments, he recovered from 50% to 80% of repigmentation only in the treated areas, without any side effects locally or systemically. Conclusion: Even if other studies are required to better determine the efficacy of this approach, this first observation about the use of the MIA-inhibitors peptides for the treatment of non-segmental vitiligo indicates that this topical preparation containing the MIA inhibitors peptides could be a very promising option for the cure of this disease.

Establishment of a promising vitiligo mouse model for pathogenesis and treatment studies

“…Hernandez et al established the vitiligo model induced by melanocyte detachment. The model does not involve an immune response and is only suitable for the study of vitiligo by non-immune mechanisms [ 16 ]. None of the existing animal models can completely simulate all the mechanisms of human vitiligo pathogenesis, but each has its own emphasis and advantages.…”