Efficacy of a Single Preoperative Dose of Pregabalin for Postoperative Pain After Septoplasty

Abstract

We aimed to investigate the role of preoperative single dose of pregabalin for attenuating postoperative pain and analgesic consumption in patients undergoing septoplasty. One hundred forty-three patients with ASA physical status I who underwent elective septoplasty were included in this prospective, randomized, and controlled study. Subjects were randomized to receive pregabalin 75 mg, pregabalin 150 mg, and control group. All the medications were administered orally 1 hour before surgery. A standard septoplasty technique was used for all patients. Postoperative pain intensity was evaluated by a 0- to 100-mm horizontal visual analog scale (VAS) (0, no pain; 100, worst imaginable pain). Total analgesic consumption 1 to 24 h after operation was also recorded.Visual analog scale scores in the 1st, 2nd, 4th, 6th, 12th, and 24th hour were significantly decreased in 75 and 150 mg pregabalin group compared with the control group, and VAS scores in the 12th and 24th hour were significantly decreased in pregabalin 150 mg compared with 75 mg. The 24th total analgesic consumption was significantly decreased in pregabalin 75 mg and 150 mg groups compared with the control group.In conclusion, a single preoperative oral dose pregabalin 75 or 150 mg is an effective method for reducing postoperative pain and total analgesic consumption in patients undergoing septoplasty.

Perioperative Pregabalin for Attenuation of Postoperative Pain After Eyelid Surgery

“…[21][22][23] It has ≥90% oral bioavailability, is minimally metabolized, and has a half-life of 6.3 hours. [7][8][9][10][11][12][13][15][16][17][18][19][20][21][23][24][25][26][27] Effective postoperative pain control is also dependent on the timing of analgesic administration. 5,13 It has been methodically compared with other analgesics/anti-inflammatories and placebo in a variety of surgical procedures, from photorefractive keratectomy to transperitoneal nephrectomy.…”

“…6,32 Several studies reported more adverse effects among those taking pregabalin. Conversely, some studies have shown pregabalin to be efficacious in single preoperative doses as low as 75 mg. 9,18 Additionally, the eyelid procedures performed have inherently low morbidity, begging the question as to whether adjunctive pain control is worth extra cost if adequate pain control can be achieved with over-the-counter pain medications. Due to the limited number of subjects, only 1 dose strength (150 mg) was administered to the treatment arm.…”

“…5 It is currently US Food and Drug Administration-approved for the treatment of epilepsy, postherpetic neuralgia, diabetic neuropathy, and fibromyalgia. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] To date, pregabalin has not been studied for oculoplastic eyelid procedures. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] To date, pregabalin has not been studied for oculoplastic eyelid procedures.…”

Pregabalin in monitored anesthesia care for ear-nose-throat surgery

“…Preoperative pregabalin (75–150 mg) has been found to be effective in reducing postoperative pain and analgesic consumption, following septoplasty under general anesthesia. [1415] Lower dose of pregabalin (50–75 mg) has been found to decrease pain score but does not reduce opioid consumption, following laparoscopic cholecystectomy. [16] Furthermore, higher doses of pregabalin (300 mg) can produce side effects such as sedation, dizziness, and blurred vision which are unwarranted in ambulatory surgeries.…”

Does a single dose of pregabalin help with postoperative pain after septoplasty?

“…Based on the findings, the authors conclude that preemptive analgesia with pregabalin may have a beneficial effect on pain management after septoplasty. In a similar study, Sagit et al 4 investigated the effect of using a single dose of perioperative pregabalin for managing postoperative pain and analgesic consumption in patients undergoing septoplasty. Instead of combining other pain medications in preemptive analgesia, two different doses of pregabalin were used for the study group.…”